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Dandan Zhang Yunzhe Liu Lili Wang Hui Ai Yuejia Luo 《Cognitive, affective & behavioral neuroscience》2017,17(1):198-210
Appropriately attending to threatening environmental stimuli is evolutionarily adaptive and crucial for survival. This study revealed that nonconscious attentional modulation of disgust has different behavioral and event-related potential (ERP) patterns, as compared to fear and anger. To facilitate its evolutionary purpose of avoidance, disgust first diverts rather than attracts attention. Accordingly, the N1 was smaller in a validly than in an invalidly disgust-cued condition. Furthermore, the frontal P3a for disgust, anger, and fear was found to be larger in the valid than in the invalid condition, which was interpreted as an involuntary switching of attention toward threat-related events to mobilize cognitive resources for action or defense. On the contrary, the parietal P3b only occurred at the conscious level; the enhanced P3b indicated that more cognitive resources were being allocated toward the task-relevant but previously less attended location, to ensure the effective achievement of task goals. In addition, group comparisons between individuals with low and high disgust sensitivity showed that the ERP differences between the disgust and the anger/fear conditions at the unconscious level may be attributed only to individuals with high disgust sensitivity. These findings, together with previous knowledge of the effects of fear and anger on attention, strengthen our confidence in the two-stage scheme of attentional modulation by threats, which consists of an early stage of bottom-up response scaling of sensory processing (reflected by the P1 and N1) and a later stage of top-down integration and regulation of emotion and behavior (reflected by the P3). 相似文献
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Male zebra finches (Taeniopygia guttata) learn to sing during a critical period in adolescence. We previously described a presynaptic protein, synelfin, whose mRNA is increased early in this critical period in a brain nucleus specifically implicated in song learning, lateral MAN (lMAN). In the current study, in situ hybridization was used to map this change in gene expression to the subregion of lMAN that projects to the robust nucleus of the archistriatum (RA), the principal motor output of the telencephalic circuit that controls song production. Using confocal immunofluorescence microscopy, we detected numerous puncta of synelfin immunoreactivity that apparently represent presynaptic terminals from lMAN in the RA of young males. Synelfin immunoreactivity in RA declined abruptly between 40 and 45 days of age, a time of major synaptic reorganization in RA. This change did not occur until about 10 days after the decline in synelfin mRNA in cell bodies within lMAN, indicating a relatively slow turnover of the protein in presynaptic terminals and suggesting that some of the functional changes that occur during the critical period may arise from regulatory decisions that were initiated a week or more earlier. Depriving birds of tutoring did not halt or delay the decline of synelfin mRNA in lMAN. This change in gene expression must not be a consequence of early song learning, but may reflect an innate or programmed step in song circuit development. 相似文献
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兼职蛋白质及其哲学思考 总被引:1,自引:0,他引:1
刘辉 《医学与哲学(人文社会医学版)》2000,21(9):25-27
在蛋白质组学天空中,新近提出的兼职蛋白质概念正越来越受到人们的关注。研究发现,某些蛋白质因其细胞定位、细胞类型、寡聚状态的不同及其配体、底物、辅因子和产物在细胞内浓度的变化而表现出不同的功能,从而对细胞和机体产生诸多有益作用,并使其发展出一系列完善机制以实现不同功能间的转换。兼职蛋白质概念的提出不仅改变了一个基因--一种蛋白质--一种功能的传统观念,也为大分子间相互作用、细胞复杂性及生物多样性研究 相似文献
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中医现代化的反思和中医的发展之路 总被引:3,自引:1,他引:3
讨论了当前所进行和提倡的中医现代化的结果不是在发展中医,而是导致了对中医的歧义的误解。认为中医的发展需要在继承的基础上,在遵循中医自身规律的前提下,在不断地纯中医方法的临床实践中,用开放的思维方式和开拓和精神发展中医的基础理论,加强中药生药的质控,用中医理论与西药匹配,加强中医的方证研究,使中医更适合社会的需要,为人类的健康事业做出应有的贡献。 相似文献
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为探讨β2-糖蛋白Ⅰ依赖性自身免疫抗体对自然流产病因诊断价值。将59名自然流产患者作为研究组,同时选择29名正常妊娠的产妇作为对照组。结论显示检测抗磷脂抗体能提高对自然流产患者病因诊断,β2-糖蛋白Ⅰ依赖性抗心磷脂抗体的特异性较单纯抗心磷脂抗体的特异性高,诊断妊娠丢失的病因更准确。 相似文献
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“修辞立其减”本为孔子读《易》解经之语,但它却对后世的文学评论及修辞学产生了深刻影响,高频率的使用还使它凝结为词——“修辞立诚”。如此,“修辞”与“立诚”在结构上成为平行并列的两个词。但从修辞角度看,二者则有密切的从属关系:“诚”内“辞”外,“诚”主“辞”从,“辞”以“诚”存。“诚”在儒家思想中的主导地位也说明,修辞应以“诚”为本,“辞”要服从并服务于“诚”。所谓“修辞立其诚”,是指以“诚”为前提并以“诚”为主导的“修辞”。 相似文献
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汉译密教佛经中直接以北斗为题材的经文集中出现在盛唐,其中印度来华僧人金刚智所译<北斗七星念诵仪轨>经中,有北斗八女字样,同经文标题北斗七星相异,在<大正藏>所选用的几个版本经文中也有所同异.笔者比对相关文献考得此北斗八女并非北斗七星之讹写,其背后是道教的北辰北斗崇拜对密教的影响.比较僧一行撰写的<北斗七星护摩法>,可从中看出密教经文在北斗崇拜上的进一步汉化:不但形式上更接近道教经文,同时此经中首次出现对火星入南斗这一传统天象的攘灾之法,是将中土星占内容融入密教佛经中的一条明证,也是天学家身份的僧一行特殊的综合工作.笔者认为金刚智的译文,保留了唐以前道教对密教在北斗崇拜上的影响,而僧一行的工作,是对密教佛经的二次汉化.对这一过程的分析,有助于辨别北斗经文的成文时间上的前后顺序,也有助于理解史传及笔记故事中北斗所具有的丰富内涵. 相似文献
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