Correlations between glucose metabolic rates in brain regions of healthy male adults at rest and during language stimulation

This study examines the effect of different behavioral conditions on patterns of correlation between regional cerebral metabolic rates for glucose. Cerebral glucose metabolism was determined with positron emission tomography and (11C)-deoxyglucose in 29 normal subjects between the ages of 23 and 55. Seventeen subjects were studied in an unstimulated (resting) condition and 12 subjects during a phoneme monitoring language stimulation. Partial correlation coefficients, controlling for whole brain glucose metabolism, were calculated for pairs of metabolic rates in 14 cortical and 2 subcortical regions. Both stimulated and unstimulated subjects showed statistically significant correlations between left and right hemisphere homologs. The stimulated subjects also showed significant within-hemisphere correlations between left but not right hemisphere regions. These included left perisylvian regions classically associated with language functions (left inferior frontal, left superior temporal and left transverse temporal cortical regions) as well as other regions. Significant correlations between left regions and a right superior temporal region were also found. In general, these findings show a pattern of cross-hemisphere symmetry at rest and of hemisphere asymmetry during stimulation. Moreover, the asymmetry observed during stimulation appears to be superimposed upon a pattern of cross-hemisphere symmetry similar to that observed in the unstimulated state.     

Implications of memory and language dysfunction in the naming deficit of senile dementia

Young normals, elderly normals, and patients with either mild-to-moderate or severe senile dementia of the Alzheimer type (SDAT) were administered several tests of language function and remote memory. On all of the language tests examined, elderly normals exhibited a mild, nonsignificant performance decrement relative to the young normals. Advanced SDAT patients were markedly impaired on all of the tests. Early dementia patients were most impaired, relative to aged normals, on tests of object naming, category instance fluency, and remote memory. The deficit was smaller on the WAIS vocabulary subtest, on selecting the name of a visually presented object, and on recalling the function of an object. Early SDAT patients were least impaired in selecting the picture of an object after its name had been provided and in selecting objects that belong to a specified functional category. The results are consistent with the notion that the language dysfunction in early SDAT is due to a deficit in semantic memory function in which general, categorical information remains available whereas information about specific attributes becomes less accessible. The object naming test might be useful in the assessment of treatment effects upon SDAT because of its sensitivity and specificity to dementia, its high face validity, and its independence of recent memory.     

Psychosocial characteristics of preschool siblings of handicapped and nonhandicapped children

This project examined psychosocial characteristics of 24 preschool-aged siblings of handicapped children in relation to a control group of 22 siblings of nonhandicapped children. Subjects were matched on family size and income, sibling age, birth order, sex, age spacing, and marital status of their parents. Results indicated no statistically significant differences between groups of children on measures of perceived self-competence and acceptance, understanding of developmental disabilities, empathy, and child care responsibility. Significant group differences were found where brothers of handicapped children were rated by their mothers as being more depressed and aggressive than brothers of nonhandicapped control children. Sisters of handicapped children were rated by mothers as being more aggressive than sisters of nonhandicapped children. Sisters of handicapped children and brothers of nonhandicapped children had significantly fewer privileges and more restrictions on their home activities than other groups. Results are discussed in relation to previous research on older silbings of handicapped children and the general literature on family stress and childhood disability and disease. The importance of examining sibling functioning via multiple measures of child behavior is stressed.The authors are grateful to the children and families who participated in the project. The assistance of Dr. Ricardo Barrera, Christine DiBlasio, Lisa Kaye, Paola Bellabarba, Jeanne Logozzo, Donna Motley, Jennifer Harter, and Tina Meisell is also gratefully acknowleged. This project was funded by Grant Number G008300345 from the U.S. Department of Education.     

Lexical contribution to nonword-repetition effects: Evidence from event-related potentials

Two experiments investigated the modulation of event-related potentials (ERPs) by the repetition of orthographically legal and illegal nonwords. In Experiment 1, subjects silently counted occasional words against a background of nonwords, a proportion of which were repetitions of an immediately preceding legal or illegal item. ERPs to repeated legal items showed a sustained, topographically diffuse, positive-going shift. In contrast, repeated illegal nonwords gave rise to ERPs showing a smaller and temporally more restricted positive-going modulation. In an attempt to equalize depth of processing across legal and illegal nonwords, subjects in Experiment 2 were required to count items containing a nonalphabetic character against the same background of nonword items. ERPs to repeated legal items showed a modulation similar to, although smaller than, that found in Experiment I, but no effects of repetition were observed in the ERPs to the illegal nonwords. It was concluded that the effects of repeating nonwords, at least as manifested in concurrently recorded ERPs, differ as a consequence of whether items can access lexical memory, and that this is inconsistent with the attribution of such effects solely to the operation of episodic memory processes.     

Social learning and collective choice

To be pertinent to democratic practice, collective choice functions need not apply to all possible constellations of individual preference, but only to those that are humanly possible in an appropriate sense. The present paper develops a theory of humanly possible preference within the context of the mathematical theory of learning. The theory of preference is then exploited in an attempt to resolve Arrow's voting paradox through restriction of the domain of majoritarian choice functions.     

Strategic hand use preferences and hemispheric specialization in tactual reading: impact of the demands of perceptual encoding

Four reading-related, information-processing tasks were administered to right-handed blind readers of braille who differed in level of reading skill and in preference for using the right hand or the left hand when required to read text with just one hand. The tasks were letter identification, same-different matching of letters that differed in tactual similarity, short-term memory for lists of words that varied in tactual and phonological similarity, and paragraph reading with and without a concurrent memory load of digits. The results showed interactions between hand preference and the hand that was actually used to read the stimulus materials, such that left preferrers were significantly faster and more accurate with their left hands than with their right hands whereas right preferrers were slightly but usually not significantly faster with their right hands than with their left hands. In all cases, the absolute magnitude of the left-hand advantage among left preferrers was substantially larger than the right-hand advantage among right preferrers. The results suggest that encoding strategies for dealing with braille are reflected in hand preference and that such strategies operate to modify an underlying but somewhat plastic superiority of the right hemisphere for dealing with the perceptual requirements of tactual reading. These requirements are not the same as those of visual reading, leading to some differences in patterns of hemispheric specialization between readers of braille and readers of print.     

Unilateral brain lesions in childhood: performance on the Revised Token Test

Comprehension of connected language as assessed by the Revised Token Test (RTT) was studied in 17 children with left hemisphere lesions (LL) and 11 with right hemisphere lesions (RL). LL children's significantly lower performance on several subtests than left controls (LC) matched by age, sex, race, and social class appeared to be related to the memory demands of these subtests rather than the limited syntactic elements assessed by the RTT. LL subjects requested significantly more command repetitions than control or RL subjects and when a repetition was not requested LL subjects often responded with immediacy. Although RL children tended to perform lower than right matched controls (RC), these differences were not significant nor readily related to either the memory or specific linguistic structures assessed. RL subjects required fewer command repetitions than LL subjects and exhibited a significantly greater frequency of immediate responses than controls or LL subjects. While based on few children, a trend for LL children with retrorolandic lesions to perform more poorly than those with left prerolandic lesions was suggested. No systematic difference in performance was apparent for children with left cortical vs. left subcortical lesions or among discrete sites of lesions within the right hemisphere. Children with left lesions prior to 1 year of age performed no better and, in several instances, significantly poorer than LL patients sustaining lesions after 1 year of age. Among RL subjects, those sustaining lesions after 1 year of age had greater difficulty than those with lesion onset before 1 year of age, especially on linguistic elements which seemed to be dependent upon visual spatial properties. Further studies are needed to evaluate the comprehension of more complex linguistic structures among children with unilateral brain lesions as well as to study the role of more basic factors such as memory and attention in explaining the present findings.     

On comprehension of active/passive sentences and language processing in a Polish agrammatic aphasic

This paper presents the results of a study of active/passive sentence comprehension by a Polish-speaking agrammatic aphasic. The patient showed good performance on canonically ordered active and passive structures, but performed poorly on inverted variants. The systematically normal and deviant comprehension patterns observed are accounted for by normal interpretative strategies applied to syntactic structures built around verbs with reduced inflectional morphology. The differences between our Polish data and the English data discussed in the literature are explained by the fact that Polish possesses a richer derivational verb morphology. The interpretation of inverted sentences demonstrates the importance of S-V-O word order preference. Our analysis draws upon the notion of grammatical functions to explain the data.