Antidepressant treatment of children: clinical relapse is unrelated to tricyclic plasma concentrations

Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.     

Physical exercise, social background, and the well-being of older adult women

28 older women participating in an exercise program were compared to 30 older women not participating in an exercise program on two behavioral measures. There were no significant main effects for participation-nonparticipation in an exercise program. Significant main effects were found, however, for each of three social variables.     

Multifactorial assessment of reading disability: identifying the best predictors

A multifactorial diagnostic assessment battery was evaluated using data obtained from 105 reading-disabled children and their matched controls (total N = 210). A stepwise discriminant function analysis selected five nonreading measures from among 16 as the best diagnostic predictors of reading disability. These measures included WISC-R Information and Digit Span, self-reported family histories of reading problems, and tests of symbol-processing speed and letter fluency.     

What can it mean to know?

This paper offers a critique of the prevailing epistemological assumptions which undergird modern Pastoral Care and Counseling education. By drawing upon emerging insights in Transpersonal Psychology and Consciousness disciplines, along with the ontological perspectives of Martin Heidegger and John Macquarrie, the attempt is made to reclaim the modes of knowing of William James and Anton Boison. This paper includes practical and concrete examples of how one supervisor is attempting to put a new paradigm into practice.