Antidepressant treatment of children: clinical relapse is unrelated to tricyclic plasma concentrations

Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.     

Behavioral analysis of sexual dysfunction in Hansen's disease

Human sexual behavior is an interactive process including CNS, hormonal, and sex-gland activities. This process can be disrupted in males who have Hansen's disease if testicular atrophy occurs. Elevations of centrally mediated luteinizing hormone and deficient testosterone levels were found in a male with Hansen's disease whose insufficient erections were secondary to atrophic testes. Quasi-experimental (A-B) analysis provided evidence for the efficacy of testosterone treatment for such a condition.     

Effects of ball color on horizontal perimetry detection

The subjects were 16 college students assessed as having normal, uncorrected visual abilities. Each subject responded to the appearance of each of five variously colored ball sections as they were introduced into the subjects' visual field. Analysis indicated that colors with luminance values greater than 70 CD/M2 (black, blue, green) were detected further in the horizontal peripheral plane than were colors possessing values less than 36 CD/M2 (red, purple).     

Size of human figure drawing and Goodenough-Harris scores of pediatric oncology patients: a pilot study

Human figure drawings of 12 pediatric oncology patients were significantly smaller in height, width, and area than were drawings of 12 school children and 12 pediatric general surgery patients paired for sex and age. The Goodenough-Harris scores of the cancer patients' drawings were also significantly lower than those of both school and general surgery groups. It is hypothesized that anxiety, lowered self-esteem, and the effects of chemotherapy contributed to these findings.     

What can it mean to know?

This paper offers a critique of the prevailing epistemological assumptions which undergird modern Pastoral Care and Counseling education. By drawing upon emerging insights in Transpersonal Psychology and Consciousness disciplines, along with the ontological perspectives of Martin Heidegger and John Macquarrie, the attempt is made to reclaim the modes of knowing of William James and Anton Boison. This paper includes practical and concrete examples of how one supervisor is attempting to put a new paradigm into practice.