Impact of genetic testing on causal models of heart disease and arthritis: An analogue study

Abstract An analogue study investigated the impact of genetic testing on perceptions of disease. Using a 2 × 2 design, participants (n = 212) imagined receiving the information that they were at increased risk for either heart disease or arthritis. The type of risk information was either genetic or unspecified. Presentation of genetic risk information resulted in the condition being perceived as less preventable. Causal models of disease where investigated using principal components analysis. When hem disease was the stimulus condition, attributions to genes and chance were positively associated following unspecified risk information, and negatively associated following genetic risk information. When arthritis was the stimulus condition, presentation of genetic risk information was associated with attributions to genes becoming separated from the other attributions. One explanation for this is that providing genetic risk information may decrease perceptions of a sense of randomness or uncertainty in disease causation. The extent to which these effects occur in clinical populations. and their behavioural consequences. needs to be established.     

Autonomic ganglionic neurones in rabbits with differing resistance to emotional stress

The aim of the present study was to evaluate the reactions of autonomic neurones of the nodose ganglion of the vagus nerve, and the stellate and superior cervical ganglia in rabbits under emotional stress, and to correlate these reactions with the individual variations in responses to the stressor. Emotional stress was induced in immobilized adult male Chinchilla rabbits by electrical stimulation of the ventromedial hypothalamus and skin. During the experiment (3 hours) arterial blood pressure (BP) was recorded. Metabolic activities of the stellate and superior cervical sympathetic ganglia and nodose ganglion were measured as contents of biogenic amines and their synthesizing and degrading enzymes, neuronal size and dry mass and total RNA; these corresponded to the changes in BP. One group of rabbits showed small fluctuations of BP throughout the experiment and were defined as resistant to stress, whereas in the other group (predisposed to stress) BP progressively decreased. In the former, there was a smaller increase of sympathetic and nodose ganglia metabolic activity than in the latter, in which changes included reduced neuronal dry mass, increased RNA content compared with controls, and reduced tyrosine hydroxylase activity and increased norepinephrine content compare with controls and stress- resistant rabbits. The predisposed rabbits showed earlier and greater increases in circulating norepinephrine concentrations than the resistant rabbits, indicating sustained sympathetic activation. The data indicate that the ganglia of the sympathetic nervous system are part of a major mechanism of BP regulation under acute experimental emotional/painful stress. The nodose ganglion participates in the maintenance of stable cardiovascular function in extreme conditions.     

The application of anticipatory avoidance learning to the treatment of homosexuality. 3. The sexual orientation method

A questionnaire technique of assessing the relative levels of homo- and hetero-erotic orientation has been constructed as part of a research project on the treatment of homosexuality by anticipatory avoidance learning. In the construction and scoring of this, the authors have borrowed from the semantic differential and personal questionnaire techniques. The technique, termed the Sexual Orientation Method (S.O.M.), is fully described and data are presented on internal consistency, uni-dimensionality, reliability and validity. The S.O.M. is intended as a quick and reasonably accurate quantitative method of assessing the response to treatment of patients known to be homosexual, and not as a method of detecting homosexuality in those not otherwise presenting with it. Applications of the scale to the assessment of changes due to treatment of sexual deviations other than homosexuality are readily possible.     

The validity of the successive intervals method of psychometric scaling

The degree to which scale values computed by the method of successive intervals diverge from theoretically true values is seen to be due to three types of error: error due to inequalities in variances of the distributions from which the scale values are computed, error due to non-normality of the distributions, and sampling error. The contribution of each type of error to the total error is evaluated; the latter is seen to be surprisingly small under appropriate conditions. Certain aspects of the formal methodology underlying scaling procedures are also briefly considered.This paper reports research undertaken in cooperation with the Quartermaster Food and Container Institute for the Armed Forces, and has been assigned number 475 in the series of papers approved for publication. The views or conclusions contained in this report are those of the authors. They are not to be construed as necessarily reflecting the views or indorsement of the Department of Defense.