An aerosol spray alternative to cigarette smoking in the study of the behavioral and physiological effects of nicotine

For studies of the behavioral and physiological effects of nicotine in smokers, delivery of nicotine via cigarette smoking is highly variable and difficult to control. A more precise method of delivery is needed in order to accurately manipulate the amount of nicotine being presented and, thus, to determine its quantitative effects. The objective of the study reported here was to test an aerosol nasal-spray method of delivering measured doses of nicotine. Eleven healthy males were presented 0 mg (placebo), 0.5 mg, 1.0 mg, and 2.0 mg of nicotine over 5 min during four separate sessions, and changes were observed in plasma nicotine concentration and cardiovascular activity. Dose-response relationships were observed between nicotine presented via this method and plasma nicotine, heart rate, systolic blood pressure, and, to a lesser extent, diastolic blood pressure. These results suggest that this aerosol spray method of presenting nicotine provides the measured doses necessary for quantification of nicotine’s effects.     

Producing high-dimensional semantic spaces from lexical co-occurrence

A procedure that processes a corpus of text and produces numeric vectors containing information about its meanings for each word is presented. This procedure is applied to a large corpus of natural language text taken from Usenet, and the resulting vectors are examined to determine what information is contained within them. These vectors provide the coordinates in a high-dimensional space in which word relationships can be analyzed. Analyses of both vector similarity and multidimensional scaling demonstrate that there is significant semantic information carried in the vectors. A comparison of vector similarity with human reaction times in a single-word priming experiment is presented. These vectors provide the basis for a representational model of semantic memory, hyperspace analogue to language (HAL).     

Sleep arrangements and night waking at 6 and 12 months in relation to infants' stress‐induced cortisol responses

The objective of this short‐term longitudinal study was to examine the concurrent and prospective associations of infants' sleep arrangements and night waking with cortisol responses to an inoculation at 6 and 12 months, controlling for several key covariates. To our knowledge, this was the first study to concurrently and prospectively link proximity in sleep arrangements and night waking to physiological stress reactivity. A sample of 92 mother–infant dyads participated in the study when the infants were 6 and 12 months of age, although sample sizes were reduced for some analyses. Both proximal cosleeping arrangements and more frequent night wakings' were associated concurrently with an increased cortisol response to inoculations at both ages. Night waking at 6 months also was associated with a slightly increased cortisol response to inoculation at 12 months. Results aimed at exploring the direction of influence suggested that cosleeping and night waking may influence infant stress physiology rather than the reverse. Adaptive and maladaptive implications of infants' nocturnal experiences and greater stress‐induced cortisol responses are discussed. Copyright © 2009 John Wiley & Sons, Ltd.     

Executable specifications for hypothesis-based reasoning with Prolog and Constraint Handling Rules

Constraint Handling Rules (CHR) is an extension to Prolog which opens up a spectrum of hypothesis-based reasoning in logic programs without additional interpretation overhead. Abduction with integrity constraints is one example of hypothesis-based reasoning which can be implemented directly in Prolog and CHR with a straightforward use of available and efficiently implemented facilities.The present paper clarifies the semantic foundations for this way of doing abduction in CHR and Prolog as well as other examples of hypothesis-based reasoning that is possible, including assumptive logic programming, hypotheses with priority and scope, and nonmonotonic reasoning.Examples are presented as executable code so the paper may also serve the additional purpose of a practical guide for developing such programs, and it is demonstrated that the approach provides a seamless integration with existing constraint solvers.     

Experience and sentence processing: statistical learning and relative clause comprehension

Many explanations of the difficulties associated with interpreting object relative clauses appeal to the demands that object relatives make on working memory. MacDonald and Christiansen [MacDonald, M. C., & Christiansen, M. H. (2002). Reassessing working memory: Comment on Just and Carpenter (1992) and Waters and Caplan (1996). Psychological Review, 109, 35-54] pointed to variations in reading experience as a source of differences, arguing that the unique word order of object relatives makes their processing more difficult and more sensitive to the effects of previous experience than the processing of subject relatives. This hypothesis was tested in a large-scale study manipulating reading experiences of adults over several weeks. The group receiving relative clause experience increased reading speeds for object relatives more than for subject relatives, whereas a control experience group did not. The reading time data were compared to performance of a computational model given different amounts of experience. The results support claims for experience-based individual differences and an important role for statistical learning in sentence comprehension processes.     

Correcting Personality Tests for Faking: A Review of Popular Personality Tests and an Initial Survey of Researchers

We reviewed a number of personality tests that are commonly used for personnel selection and found that some of the more popular tests provide a “correction” for faking. Additionally, a survey of researchers' preferences regarding correcting personality test scores for faking was conducted. The respondents, who were experienced in using personality tests for industrial‐organizational purposes, generally favored the use of faking corrections (69% were in favor). The apparently common practice of correcting personality scores for faking was contrasted with relevant conceptual, empirical, and statistical concerns as to the advisability of applying the correction for faking.