The role of protein synthesis during the labile phases of memory: revisiting the skepticism

Despite the fact that extensive evidence supports the view that phases of de novo protein synthesis are necessary for memory formation and maintenance, doubts are still raised. Skeptics generally argue that amnesia and the disruption of long-term synaptic plasticity are caused by "non-specific effects" of the reagents or approaches used to disrupt protein synthesis. This paper attempts to clarify some of these issues by reviewing, discussing and providing results addressing some of the major critiques that argue against the idea that de novo protein synthesis is necessary for the stabilization of long-term memory.     

Young children's psychological explanations and their relationship to perception‐ and intention‐understanding

The present study examined two key aspects of young children's ability to explain human behaviour in a mentalistic way. First, we explored desires that are of a level of difficulty comparable with that of false beliefs. For this purpose, the so‐called ‘alternative desires’ were created. Second, we examined how children's psychological explanations are related to their understanding of perception and intention. A perception‐understanding task, an intention‐understanding task and a psychological‐explanation task were administered to 80 three‐year‐olds. Results offer support for the thesis that the level of difficulty of belief and desire explanations is comparable. Moreover, children's psychological explanations are related to their understanding of perception and intention. The results lend support to the idea that mentalistic explanations are an explicit manifestation of children's level of theory of mind. Copyright © 2008 John Wiley & Sons, Ltd.     

Reconceptualizing relative deprivation in the context of dramatic social change: the challenge confronting the people of Kyrgyzstan

The present study investigated the relationship between Temporal Collective Relative Deprivation and collective well‐being in the context of dramatic social change in Kyrgyzstan. Traditional research has evaluated Temporal Collective Relative Deprivation by comparing a group's present situation to a point in the recent past or future. We argue that a reconceptualization of Temporal Collective Relative Deprivation is needed. We hypothesized, first, that examining several, as opposed to a single, points of comparison will better predict collective well‐being. Secondly, we hypothesized that the points of comparison that will best predict collective well‐being will not necessarily correspond to the most recent past or future. Third, we hypothesized that the overall trajectory of Temporal Collective Relative Deprivation perceived across time will influence the level of collective well‐being. A sample of 565 Kyrgyz participants completed a questionnaire. Hierarchical regressions and group‐based trajectory modeling confirmed our three hypotheses. Theoretical and methodological implications of the findings are discussed. Copyright © 2008 John Wiley & Sons, Ltd.     

Do the right thing: but only if others do so

Social norms play an important role in individual decision making. We argue that two different expectations influence our choice to obey a norm: what we expect others to do (empirical expectations) and what we believe others think we ought to do (normative expectations). Little is known about the relative importance of these two types of expectation in individuals' decisions, an issue that is particularly important when normative and empirical expectations are in conflict (e.g., systemic corruption, high crime cities). In this paper, we report data from Dictator game experiments where we exogenously manipulate dictators' expectations in the direction of either selfishness or fairness. When normative and empirical expectations are in conflict, we find that empirical expectations about other dictators' choices significantly predict a dictator's own choice. However, dictators' expectations regarding what other dictators think ought to be done do not have a significant impact on their decisions after controlling for empirical expectations. Our findings about the crucial influence of empirical expectations are important for designing institutions or policies aimed at discouraging undesirable behavior. Copyright © 2008 John Wiley & Sons, Ltd.     

Effects of repetitive stress during the acute phase of Trypanosoma cruzi infection on chronic Chagas' disease in rats

The effect of repetitive stress during acute infection with Trypanosoma cruzi (T. cruzi) on the chronic phase of ensuing Chagas' disease was the focus of this investigation. The aim of this study was to evaluate in Wistar rats the influence of repetitive stress during the acute phase of infection (7 days) with the Y strain of T. cruzi on the chronic phase of the infection (at 180 days). Exposure to ether vapor for 1 min twice a day was used as a stressor. Repetitive stress enhanced the number of circulating parasites and cardiac tissue disorganization, from a moderate to a severe diffuse mononuclear inflammatory process and the presence of amastigote burden in the cardiac fibers. Immunological parameters revealed that repetitive stress triggered a reduced concanavalin A induced splenocyte proliferation in vitro with major effects on the late chronic phase. Serum interleukin-12 concentration decreased in both stressed and infected rats in the early phase of infection although it was higher on 180 days post-infection. These results suggest that repetitive stress can markedly impair the host's immune system and enhance the pathological process during the chronic phase of Chagas' disease.     

Attention control and susceptibility to hypnosis

The present work aimed at assessing whether the interference exerted by task-irrelevant spatial information is comparable in high- and low-susceptible individuals and whether it may be eliminated by means of a specific posthypnotic suggestion. To this purpose high- and low-susceptible participants were tested using a Simon-like interference task after the administration of a suggestion aimed at preventing the processing of the irrelevant spatial information conveyed by the stimuli. The suggestion could be administered either in the absence or following a standard hypnotic induction. We showed that, outside from the hypnotic context, the Simon effect was similar in high and low-susceptible participants and it was significantly reduced following the posthypnotic suggestion in high-susceptible participants only. These results show that a specific posthypnotic suggestion can alter information processing in high-susceptible individuals and reduce the interfering effect exerted by arrow stimuli.     

Stroop effects on redemption and semantic effects on confession: simultaneous automatic activation of embedded and carrier words

The present study was aimed at assessing whether focusing attention on a task-relevant part of a word prevents processing of its meaning. Participants performed a color-naming task on a prime word followed by lexical decision on a probe. Primes were words, which could contain an embedded color word (e.g., “redemption”) written in an incongruent color. Probes were either semantically related (e.g., “confession”) or unrelated (e.g., “production”) to the prime word. A Stroop effect emerged for color words appearing either in the initial or in the final position of the carrier word. A priming effect also emerged, with faster responses to probes semantically related to the prime. These results are evidence that focusing attention on part of a prime (i.e., the embedded color word) does not prevent the semantic processing of the entire word.     

Virtual Reality Exposure in the Treatment of Panic Disorder With Agoraphobia: A Case Study

In this work we present a case example of the use of virtual reality exposure for the treatment of panic disorder with agoraphobia. The assessment protocol and procedure (including a baseline period) and the cognitive-behavioral treatment program are described. The clinical measures were categorized into target behaviors, panic and agoraphobia measures, global functioning, and general psychopathology measures. The patient’s expectations and satisfaction with regard to the virtual treatment were also assessed. The results showed an important reduction in all clinical measures after treatment with virtual exposure and the patient reached the therapeutic goals established during the pretreatment assessment. The patient also reported a good acceptance of virtual exposure. The goals achieved in the virtual environment generalized to real agoraphobic situations and to other real situations not treated. Three-, 6-, and 12-month follow-up assessments were conducted and long-term therapeutic gains were maintained.     

Validity of virtual reality as a method of exposure in the treatment of test anxiety

This is a validation study, aiming to explore the effectiveness of a set of virtual environments forproducing emotionally significant responses in students with high levels of test anxiety in order to be able to implement them later in treatment. Twenty-one students agreed to take part, 11 with high test anxiety and 10 with low test anxiety. The virtual environments were prepared in chronological order: the student's home, then the metro, and finally the corridor and lecture hall where the examination takes place. The results showed that the high-test-anxiety group presented higher levels of anxiety and depression than the low-test-anxiety group during exposure to the virtual environments. This study shows that virtual reality is able to provoke emotional responses in students with high test anxiety. This validation study should be followed up with treatment studies to evaluate the efficacy of virtual reality therapy for treating testanxiety.