Changes in the neuropsychological correlates of clinical dimensions between the acute and stable phase of schizophrenia

This study was designed to investigate whether the neuropsychological correlates of the symptom dimensions of schizophrenia vary with the clinical state in patients followed from the acute to stable the phase of the illness. Fifteen patients were assessed for symptoms (SAPS-SANS) and undergone a complete neuropsychological assessment at two sessions. The first session (S1) was carried out within six days after admission, i.e., acute phase and the second (S2) at least two month after hospitalization, i.e., stable phase. The data were analyzed using stepwise regression models in which neuropsychological scores were in entered to predict each dimensional score. This analysis was applied on the S1 and S2 data as well as on the S2-S1 difference to assess the neuropsychological predictors of clinical changes. Generally, the results replicate the previous associations between neuropsychological and dimensional measures found in stable patients. In addition, this study shows if each dimension appears to rely on a key structure, symptom variations seems to involve changes in the spread of the dysfunction and/or changes in the connectivity between the key and other regions. The results also suggest that functional changes related to some symptoms dimensions occur to compensate for the dysfunction associated with other symptoms.     

Racial Differences in Responses to the Caregiver Strain Questionnaire

The aim of this study was to examine differences in responses to the Caregiver Strain Questionnaire (CGSQ) between African American and White caregivers of children with emotional and behavioral challenges. Significant item- and scale-level differences were detected across groups with African Americans consistently reporting less strain. We examined whether these differences were more likely due to nonequivalent measurement than to real differences in the experience of caregiver strain. Confirmatory factor analysis showed that the model fit the data well for both racial groups, but there were some differences in structural components. Internal consistency was equivalent across the groups. In an examination of criterion validity, regression analyses showed that African American caregivers experienced a slower rate of increase in objective caregiver strain at a given increase in child internalizing problems. No other race differences were found in the regression analyses. In general, we conclude that the CGSQ can be useful for detecting caregiver strain and identifying family support needs for both White and African American caregivers. Differences across groups in reports of caregiver strain, however, call for more research on racial differences in the impact on the family of caring for a child with emotional and behavioral disorders.     

AIDS and social exclusion: personality features or adaptive behaviors?

The purpose of this survey is to detect common personality features in people infected with AIDS who have a case history of drug addiction and who live in a situation of social exclusion. The sample comprised 105 male participants from the Autonomous Community of Andalusia, divided into 4 groups: (a) 30 men with AIDS, having an intravenous drug addiction case history and who live in a condition of social exclusion; (b) 30 men with IVDA case history, also living in a situation of social exclusion; (c) 15 men in a social exclusion condition; and (d) 30 men in a condition of social adaptation. The evaluation instruments were an author-designed semi-structured interview and the Multiaxial Clinical Inventory (MCMI-II; Millon, 1987). Although some differences were found, the results indicate that there is no specific personality profile in the "social exclusion" population. People in a condition of social exclusion (AIDS, drug addicts, and poor people) may obtain similar scores in the variables studied, but there is no clear specific personality profile in the excluded population, although there may be certain situations in which the segregated groups present similar behaviors. Furthermore, these behaviors do not always correspond to personality features but are adaptive responses to a harsh and complex reality.     

Category norms for 500 Spanish words in five semantic categories

This study presents a database of 500 words from five semantic categories: animals, body parts, furniture, clothing, and intelligence. Each category contains 100 words, and data on lexical availability, age of acquisition, imageability, typicality, concept familiarity, written word frequency, and word length in number of syllables are provided with each word. The full set of norms may be downloaded from www.psychonomic.org/archive.     

A study of 60- to 89-mo.-old children's skill at writing numerals

The skill of writing numerals necessitates a certain developmental maturity. Studying the age at which children start to develop this skill and assessing problems they encounter while writing numerals should give direction to their training. From 8 schools a total of 267 children, ages 60 to 89 mo., were asked to write the numerals 1 to 9. Analysis showed that 80% of the children wrote most of the numerals correctly, 15% wrote inverted numerals, 2.0% wrote some numerals as letters, and 4% did not write certain numerals at all. In addition, 64% of children ages 60 to 65 mo. gave correct responses, and the perception of correct responses increased across age groups until 95% were correct in the group who were 84 to 89 mo. There was no significant difference between girls and boys in these writing skills.     

Spatial learning in rats is impaired by microinfusions of protein kinase C-gamma antisense oligodeoxynucleotide within the nucleus accumbens

The nucleus accumbens (NAcc) has been shown to play a role in motor and spatial learning. Protein kinase C (PKC) has been implicated in the mechanisms of initiation and maintenance of long-term potentiation that is thought to be involved in the storage of long-term memory. In the present study, the importance of de novo synthesis of PKC-gamma within the NAcc in the acquisition and retention of spatial discrimination learning was assessed using an antisense knockdown approach. Separate groups of Long-Evans rats were exposed to acute microinfusions (6microg/microl) of PKC-gamma antisense oligodeoxynucleotide (AS-ODN), control oligodeoxynucleotide (C-ODN) or vehicle into the NAcc at 24 and 3h before each training session. Behavioral findings showed that the blockade of NAcc-PKC-gamma translation caused impairments in the early phase of learning and retention of spatial information. Biochemical experiments showed that PKC-gamma expression was reduced and Ca(2+)/phospholipid-dependent protein kinase C (PKC) activity was blocked significantly in the AS-ODN-treated rats in comparison with control rats. The present findings suggest that NAcc-PKC-gamma plays a role during the early acquisition of spatial learning. Also, retention test results suggest that NAcc-PKC-gamma may be working as an intermediate factor involved in the onset of molecular mechanisms necessary for spatial memory consolidation within the NAcc.     

Exploring the structure of Zuckerman's Sensation Seeking Scale, Form V in a Spanish sample

The psychometric properties of the original version of the Sensation Seeking Scale (Form V) were analyzed in a sample of 1,006 Spanish university students. The total sample was randomly split into two halves. Exploratory factor analyses were conducted on the calibration sample (n=504), whereas confirmatory factor analysis procedures were performed on the validation sample (n=502). As previous studies have suggested, exploratory factor structure indicated that several items load on a different factor or have loadings lower than .30. Those problems were surpassed when the best five items per factor were factor analyzed again. The confirmatory factor analyses showed that a 4-factor simple structure model gave a clearly imperfect fit. A model of 20 items (5 items per factor) gave a better fit, although with similar problems regarding the low reliabilities of the Experience Seeking and Boredom Susceptibility subscales. The need for improvement of the four-factor structure is discussed.     

On the representation of Portuguese gender-inflected words in the mental lexicon

This study aims at verifying whether Portuguese gender-inflected nouns and adjectives are represented as full forms as suggested by Spanish data (Dominguez, Cuetos, & Segui, 1999). A series of lexical decision experiments is reported. Grammatical gender, frequency dominance, and grammatical category are manipulated and cumulative frequency is controlled. The results do not provide support for a full form representation of gender-inflected words. They suggest that grammatical category, or the nature of the inflectional process involved (lexical or syntactic), affects the way words are represented and accessed. Shorter recognition latencies were obtained for nouns drawn from Feminine dominant gender-inflected pairs than from Masculine dominant pairs whereas a tendency in the opposite direction was observed in adjectives. The effect of frequency dominance appears, nevertheless, to be restricted to feminine nouns. The data are compatible with the view that masculine nouns and adjectives are represented as gender-unmarked forms. These results are discussed in relation to current dual-access models of word recognition and to the notion of "interpretability" of lexico-syntactic features, as put forward in the Minimalist Program of Generative Linguistics.     

Perseverative responding in a violation-of-expectation task in 6.5-month-old infants

In the present research, 6.5-month-old infants perseverated in a violation-of-expectation task designed to examine their reasoning about width information in containment events. After watching a familiarization event in which a ball was lowered into a wide container, the infants failed to detect the violation in a test event in which the same ball was lowered into a container only half as wide as the ball (narrow-container test event). This negative result (which was replicated in another experiment) was interpreted in terms of a recent problem-solving account of infants' perseverative errors in various means-end tasks (Aguiar, A., & Baillargeon, R. (2000). Perseveration and problem solving in infancy. In H. W. Reese (Ed.), Advances in child development and behavior (Vol. 27, pp. 135-180). San Diego, CA: Academic Press). It was assumed that the infants in the present experiments (1) did not attend to the relative widths of the ball and container in their initial analysis of the narrow-container test event, (2) categorized the event as similar to the familiarization event shown on the preceding trials, and (3) retrieved the expectation they had formed for that event ("the ball will fit into the container"), resulting in a perseverative error. This interpretation was supported by additional experiments in which different modifications were introduced that led to non-perseverative responding, indicating that 6.5-month-old infants could detect the violation in the narrow-container test event. The present findings are important for several reasons. First, they provide the first demonstration of perseverative responding in a violation-of-expectation task. Second, they make clear the breadth and usefulness of the problem-solving account mentioned above. Finally, they add to the evidence for some degree of continuity between infants' and adults' problem-solving abilities.