Conditioned fear is modulated by D2 receptor pathway connecting the ventral tegmental area and basolateral amygdala

Excitation of the mesocorticolimbic pathway, originating from dopaminergic neurons in the ventral tegmental area (VTA), may be important for the development of exaggerated fear responding. Among the forebrain regions innervated by this pathway, the amygdala is an essential component of the neural circuitry of conditioned fear. The functional role of the dopaminergic pathway connecting the VTA to the basolateral amygdala (BLA) in fear and anxiety has received little attention. In vivo microdialysis was performed to measure dopamine levels in the BLA of Wistar rats that received the dopamine D(2) agonist quinpirole (1 μg/0.2 μl) into the VTA and were subjected to a fear conditioning test using a light as the conditioned stimulus (CS). The effects of intra-BLA injections of the D(1) antagonist SCH 23390 (1 and 2 μg/0.2 μl) and D(2) antagonist sulpiride (1 and 2 μg/0.2 μl) on fear-potentiated startle (FPS) to a light-CS were also assessed. Locomotor performance was evaluated by use of open-field and rotarod tests. Freezing and increased dopamine levels in the BLA in response to the CS were both inhibited by intra-VTA quinpirole. Whereas intra-BLA SCH 23390 did not affect FPS, intra-BLA sulpiride (2 μg) inhibited FPS. Sulpiride's ability to decrease FPS cannot be attributed to nonspecific effects because this drug did not affect motor performance. These findings indicate that the dopamine D(2) receptor pathway connecting the ventral tegmental area and the basolateral amygdala modulates fear and anxiety and may be a novel pharmacological target for the treatment of anxiety.     

Cognitive-behavioral intervention among women with slight menopausal symptoms: a pilot study

Menopause is associated with a considerable variety of physical, psychological and social symptoms that can be treated using cognitive-behavioral techniques. In the present study, 21 women took part in an eight-week group intervention consisting of weekly two-hour sessions to address their slight symptoms related to the climacteric stage of life. The intervention included: psycho education on menopause, relaxation techniques, nutrition and fitness exercises, Kegel exercises, and problem-solving techniques. A control group was included that did not receive treatment and consisted of 28 women. The results revealed a significant reduction in most symptoms (including depression and anxiety) after intervention as compared to the baseline period. No changes appeared in the control group. The relevance of this work lies in the potential element of prevention this therapeutic package could offer to relieve various symptoms, slight and incipient, during the perimenopausal stage.     

Effects of changes in narrative time on eye movements and recognition responses

Abstract

Gibbs and O'Brien (1990) recently claimed that the images that people associate with everyday idioms reflect the deep conceptual metaphors that underlie the meanings of those idioms. However, because idiomatic strings can convey both a literal and an idiomatic meaning, people must be able to inhibit or ignore literal meanings if they are to produce mental images that uniquely reflect idiomatic meanings. We investigated the potential interference between literal and idiomatic meanings in three experiments. Experiment 1 used a mental-image production task similar to that used by Gibbs and O'Brien. Counter to Gibbs and O'Brien's claim, the images that we obtained referred overwhelmingly to the literal meanings of idiomatic strings rather than to their idiomatic meanings. Experiments 2 and 3 employed a paraphrase verification task to examine the effects of mental imagery on idiom comprehension. If the images associated with an idiom reflect that idiom's meaning, then imagery should facilitate comprehension. No evidence for facilitation was found in either experiment. Instead, imagery interfered with comprehension, as assessed by paraphrase verification time, both for idiomatic meanings and for literal, concrete meanings. We conclude that the images associated with idioms do not reflect idiom meanings.     

Coping assessment in adolescents

The aim of this work was to obtain an abridged form of the Adolescent Coping Scale (Spanish version) that included items representative of the various factorial dimensions identified as stable. The scale (80 items) was administered to 800 Argentine adolescents. Factor analyses, principal axes and oblimin solution, were performed. An abridged scale was obtained, consisting of 46 items that were grouped into 11 dimensions: Cognitive Redefinition, Self-Blame, Fatalism, Evasion Through Amusement, Problem-Focused Coping (which includes requests for information and action), Evasion Through Physical Activity, Emotional Support, Emotional Discharge and Somatization, Anxiety, Isolation, and No Action. The reliability coefficients were found to be satisfactory.     

A meta-analytic study of general mental ability validity for different occupations in the European community

A comprehensive meta-analysis of the validity of general mental ability (GMA) measures across 12 occupational categories in the European Community (EC) is presented. GMA measures showed that there is validity generalization and large operational validities for job performance and training success in 11 occupational groups. Results also showed that job complexity moderated the magnitude of the operational validity of GMA tests across three levels of job complexity: low, medium, and high. In general, results were similar to those found in the United States, although the European findings showed a slightly larger magnitude of operational validity in some cases. Theoretical and practical implications of these findings for personnel selection are discussed. ((c) 2003 APA, all rights reserved)     

Controlling for causally relevant third variables

In 3 experiments, the authors tested the conditions under which 3rd variables are controlled for in making causal judgments. The authors hypothesized that 3rd variables are controlled for when the 3rd variables are themselves perceived as causal. In Experiment 1, the participants predicted test performance after seeing information about wearing a lucky garment, taking a test-preparation course, and staying up late. The course (perceived as more causally relevant) was controlled for more than was the garment (perceived as less causally relevant) in assessing the effectiveness of staying up late. In Experiments 2 and 3, to obviate the many alternative accounts that arise from the realistic cover story of Experiment 1, participants predicted flowers' blooming after the presentation or nonpresentation of liquids. When one liquid was trained as causal, it was controlled for more in judging another liquid than when it was trained as neutral. Overall, stimuli perceived as causal were controlled for more when judging other stimuli. The authors concluded that the effect of perceived causal relevance on causal conditionalizing is real and normatively reasonable.     

The role of subsyllabic structure in lexical access to printed words

Summary Three lexical-decision experiments investigated whether the subsyllabic structure of words is processed in the course of lexical access to printed words. Experiment 1 contrasted Italian words with same orthographic structure, but different subsyllabic structures. Latencies were shorter and error rates lower for words with a syllabic structure composed of fewer subsyllabic constituents. Experiment 2 ruled out the possibility that the results of Experiment 1 were due to differences in the frequency of bigrams composing the items. Bigram frequency had no effect on words of the same frequency as that of words in Experiment 1. Finally, Experiment 3 showed that it is not the number of subsyllabic constituents that affects lexical decision — rather the internal composition and frequency of the subsyllabic structure underlying a word. These results suggest that the subsyllabic structure of words is represented in abstract form in the mental lexicon and processed during lexical access. Subsyllabic structures, which are simpler and more common in the language, are more easily activated and processed, regardless of the number of subsyllabic constituents and the number of syllables composing the word.     

Preferred Attributes of Effective Conflict Resolvers in Seven Societies: Culture,Development Level,and Gender Differences1

This research examined variations in preferred personality attributes of conflict resolvers. Using a semantic differential scale, youth from Malaysia, Japan, China, Philippines, Australia, Germany, and the United States described an effective conflict resolver. ANOVA procedures tested whether culture, country's level of economic development, or gender produced significant variations on conflict resolver preferences. Results show that conflict resolvers can be described along a continuum that has a compassionate peacemaker on one side and a dominating peacemaker on the other. Cultural differences produced marginal significance. The stronger effects were results of variations in power positions. A compassionate peacemaker was preferred by respondents from developing societies, rather than by those from the wealthier countries, and by women more than men.     

Maternal perinatal representations and their associations with mother–infant interaction and attachment: A longitudinal comparison of Portuguese and Brazilian dyads

Prior research in Western countries (mostly the US, Canada and northern Europe) indicates that mothers' representations are associated with mother–infant interaction quality and their child's attachment security later in the first year. Fewer studies, however, have evaluated whether these associations hold for mother–infant dyads in other countries, such as Brazil and Portugal. Although these countries share a similar language and culture, they differ on societal dimensions that may affect parenting attitudes and mother–infant relationships, such as economic stress, social organisation, social policy, and the availability of services for young families. In this longitudinal study, we followed two independent samples of Brazilian and Portuguese mother–infant dyads from the perinatal period to 12 months post-partum. We assessed mothers' perinatal representations using semi-structured interviews in the first 48 hours after the infant's birth, and evaluated the associations of these representations with mother interaction quality at 9 months and infant attachment at 12 months. Results were similar in each country, corroborating prior research in single Western countries: Mothers with more positive perinatal representations were more sensitive to their infants during free play at 9 months and were more likely to have infants classified as securely attached at 12 months.     

The Internet as Cognitive Enhancement

Science and Engineering Ethics - The Internet has been identified in human enhancement scholarship as a powerful cognitive enhancement technology. It offers instant access to almost any type of...