Object recognition in Williams syndrome: uneven ventral stream activation

Williams syndrome (WS) is a genetic disorder associated with severe visuospatial deficits, relatively strong language skills, heightened social interest, and increased attention to faces. On the basis of the visuospatial deficits, this disorder has been characterized primarily as a deficit of the dorsal stream, the occipitoparietal brain regions that subserve visuospatial processing. However, some evidence indicates that this disorder may also affect the development of the ventral stream, the occipitotemporal cortical regions that subserve face and object recognition. The present studies examined ventral stream function in WS, with the hypothesis that faces would produce a relatively more mature pattern of ventral occipitotemporal activation, relative to other objects that are also represented across these visual areas. Using functional magnetic imaging, we compared activation patterns during viewing of human faces, cat faces, houses and shoes in individuals with WS (age 14-27), typically developing 6-9-year-olds (matched approximately on mental age), and typically developing 14-26-year-olds (matched on chronological age). Typically developing individuals exhibited changes in the pattern of activation over age, consistent with previous reports. The ventral stream topography of individuals with WS differed from both control groups, however, reflecting the same level of activation to face stimuli as chronological age matches, but less activation to house stimuli than either mental age or chronological age matches. We discuss the possible causes of this unusual topography and implications for understanding the behavioral profile of people with WS.     

Telling the right hand from the left hand: multisensory integration, not motor imagery, solves the problem

Judging the laterality of a hand seen at unanticipated orientations evokes a robust feeling of bodily movement, even though no movement is produced. In two experiments, we tested a novel hypothesis to explain this phenomenon: A hand's laterality is determined via a multisensory binding of the visual representation of the seen hand and a proprioceptive representation of the observer's felt hand, and the felt "movement" is an obligatory aftereffect of intersensory recalibration. Consistent with the predictions implied by such a cross-modal mechanism, our results in Experiment 1 showed that manipulating observers' selective attention can evoke illusory feelings of movement in the "wrong" hand (i.e., the hand whose laterality does not match that of the stimulus). In Experiment 2, these illusions were readily extinguished in conditions in which binding was predicted to fail, a result indicating that cross-modal binding was necessary to produce them. These results are not explained by imagery, a mechanism widely assumed to account for how hand laterality is identified.     

Myosin II motor activity in the lateral amygdala is required for fear memory consolidation

Learning induces dynamic changes to the actin cytoskeleton that are required to support memory formation. However, the molecular mechanisms that mediate filamentous actin (F-actin) dynamics during learning and memory are poorly understood. Myosin II motors are highly expressed in actin-rich growth structures including dendritic spines, and we have recently shown that these molecular machines mobilize F-actin in response to synaptic stimulation and learning in the hippocampus. In this study, we report that Myosin II motors in the rat lateral amygdala (LA) are essential for fear memory formation. Pretraining infusions of the Myosin II inhibitor, blebbistatin (blebb), disrupted long term memory, while short term memory was unaffected. Interestingly, both post-training and pretesting infusions had no effect on memory formation, indicating that Myosin II motors operate during or shortly after learning to promote memory consolidation. These data support the idea that Myosin II motor-force generation is a general mechanism that supports memory consolidation in the mammalian CNS.     

Attention training to reduce attention bias and social stressor reactivity: an attempt to replicate and extend previous findings

Cognitive theories suggest that social anxiety is maintained, in part, by an attentional bias toward threat. Recent research shows that a single-session of attention modification training (AMP) reduces attention bias and vulnerability to a social stressor (Amir, Weber, Beard, Bomyea, &; Taylor, 2008). In addition, exercise may augment the effects of attention training by its direct effects on attentional control and inhibition, thereby allowing participants receiving the AMP to more effectively disengage attention from the threatening cues and shift attention to the neutral cues. We attempted to replicate and extend previous findings by randomizing participants (N = 112) to a single-session of: a) Exercise + attention training (EX + AMP); b) Rest + attention training (REST + AMP); c) Exercise + attention control condition (EX + ACC); or d) Rest + attention control condition (REST + ACC) prior to completing a public speaking challenge. We used identical assessment and training procedures to those employed by Amir et al. (2008). Results showed there was no effect of attention training on attention bias or anxiety reactivity to the speech challenge and no interactive effects of attention training and exercise on attention bias or anxiety reactivity to the speech challenge. The failure to replicate previous findings is discussed.     

On Christ and Healing: Eiesland,Tillich, and Disability Theology

Abstract : The existentialist interpretation of the biblical texts offered by Protestant theologian Paul Tillich is deeply problematic in its treatment of disability, especially mental illness. Theologian Nancy Eiesland argues against a conflation of sin and illness, and proposes the symbol of the disabled God as a source for a liberation theology of disability. Reading the biblical texts existentially, as Tillich suggests, can advance Eiesland's Christology, while her critique of Christian teaching on disability offers a correction for Tillich.     

Positive outcomes of social norm transgressions

Norm transgressions occur when consumers behave outside social expectations; such transgressions often cause embarrassment for the perpetrator and negative responses from witnesses. This study asks if norm violations can lead to positive audience responses. The study relies on 246 written reports from norm breakers and finds positive audience responses occurring almost 17 per cent of the time, with an additional 26 per cent of cases providing a mix of both positive and negative reactions. A content analysis of influence factors suggests that the emergence of a positive outcome depends on the importance of the norm, the position of the perpetrating behavior relative to the broader scope of the norm, and the rewards received by the audience as a result of the norm transgression. These factors are illustrated by representative participant quotes. The findings have implications for theory as well as marketing practice. Copyright © 2014 John Wiley & Sons, Ltd.     

Graphic Pathogeographies

This paper focuses on the graphic pathogeographies in David B.’s Epileptic and David Small’s Stitches: A Memoir to highlight the significance of geographic concepts in graphic novels of health and disease. Despite its importance in such works, few scholars have examined the role of geography in their narrative and structure. I examine the role of place in Epileptic and Stitches to extend the academic discussion on graphic novels of health and disease and identify how such works bring attention to the role of geography in the individual’s engagement with health, disease, and related settings.     

Exploring Women's Expectations of Recovery From Intimate Partner Violence: A Phenomenological Study

Occupational therapy literature related to intimate partner violence primarily focuses on clients' pragmatic concerns. The purpose of this study was to explore women's recovery needs for the first six months after leaving the abusive relationship. Specifically, the focus explored how women experiencing intimate partner violence anticipate their recovery process to progress and explored their perceptions regarding the obstructions and challenges that influence that process. As part of an ongoing, multiyear study, in-depth interviews based on Kawa Model river drawings were conducted at a domestic violence center with eight women. Multiple themes were identified highlighting pragmatic and personal objectives.     

Influence of Question Format and Text Availability on the Assessment of Expository Text Comprehension

This study examines how passage availability and reading comprehension question format (open-ended vs. multiple-choice) influence question answering. In two experiments, college undergraduates read an expository passage and answered open-ended and multiple-choice versions of text-based, local, and global bridging inference questions. Half the participants were allowed to refer to the passage when answering the questions and half were not. Participants' prior domain knowledge relating to the text contents was assessed using multiple-choice and open-ended questions. Correlation-based analyses in the two experiments indicated: (a) a decline in the relationship between prior domain knowledge and comprehension when the passage was available during question answering; and (b) a high correlation between multiple-choice and open-ended question answering performance when the passage was not available for reference. Overall the results indicate that the nature of the reading comprehension assessment is influenced by the specific task with which comprehension is assessed.     

No face is an island: How implicit bias operates in social scenes

Social psychologists have mainly studied implicit attitudes toward faces presented one at a time, whereas, in real life, we often encounter people in the presence of others. These surrounding individuals may alter attitudes toward the focal target of attention. We employed a flanker-IAT task and found that, when black and white targets were presented in racially diverse contexts, bias was decreased. This decrease in bias occurred even when targets previously seen in diverse contexts were presented on their own, suggesting context-free evaluations of the targets had been formed. Experiment 2 showed that the effect of diverse contexts does not affect bias toward a racial category as a whole, but only the specific targets previously seen in the diverse contexts. Quad model analysis (Sherman et al., 2008) revealed that these effects were related to changes in automatic evaluations, and not to changes in inhibition. Implications for implicit bias change and prejudice reduction strategies are discussed.