Is overt stuttered speech a prerequisite for the neural activations associated with chronic developmental stuttering?

Four adult right-handed chronic stutterers and four age-matched controls completed H(2)(15)O PET scans involving overt and imagined oral reading tasks. During overt stuttered speech prominent activations occurred in SMA (medial), BA 46 (right), anterior insula (bilateral), and cerebellum (bilateral) plus deactivations in right A2 (BA 21/22). These activations and deactivations also occurred when the same stutterers imagined they were stuttering. Some parietal regions were significantly activated during imagined stuttering, but not during overt stuttering. Most regional activations changed in the same direction when overt stuttering ceased (during chorus reading) and when subjects imagined that they were not stuttering (also during chorus reading). Controls displayed fewer similarities between regional activations and deactivations during actual and imagined oral reading. Thus overt stuttering appears not to be a prerequisite for the prominent regional activations and deactivations associated with stuttering.     

Lysergic Acid Diethylamide (LSD 25) and behaviour therapy

This paper deals with the problems involved in the treatment of complex neurotic conditions. A seventh feature is added to Wolpe's list of the six features that make a neurosis complex. The use of Lysergic Acid Diethylamide (LSD 25) in the treatment of such difficult cases is discussed and three cases are presented.     

HIV infection with immunodeficiency presenting with subacute cognitive decline: recent illustrative cases

We describe three recent patients in whom evaluation of subacute, progressive encephalopathy led to the initial diagnosis of human immunodeficiency virus infection. The clinical neurological picture of a predominance of abnormalities of mental function with few elementary neurological deficits, in conjunction with a paucity of systemic symptoms and lack of evidence for prior opportunistic infections preceding the encephalopathy are notable. The cognitive, behavioral, and neuropsychiatric disturbances are described in detail to illustrate the range of manifestations of disordered mental states associated with encephalopathy in individuals with HIV infection. The importance of a comprehensive and broad-minded work-up by brain magnetic resonance imaging, cerebrospinal fluid examination, and specific microbiological tests in delineating the potential multifactorial pathogenesis of the cerebral syndromes in relation to the HIV infection is emphasized. The gratifying long-term clinical improvements in parallel with resolution of neuroimaging and other laboratory abnormalities in response to antiretroviral drug treatment are reported.     

Intergroup disgust sensitivity as a predictor of islamophobia: The modulating effect of fear

The present research investigated whether intergroup disgust sensitivity (ITG-DS) predicts greater Islamophobia, and whether this positive association is modulated (strengthened or weakened) by the experience of concurrent incidental non-disgust emotions (fear, sadness, anger, happiness). In Study 1 (N = 225) participants completed measures of ITG-DS (an emotionally charged individual difference variable reflecting heightened tendency to experience disgust and revulsion reactions toward ethnic outgroup encounters) and dispositional measures of fear, sadness, anger, and happiness. Results revealed that among those experiencing greater (vs. lower) fear or sadness, the positive relation between ITG-DS and Islamophobia was significantly stronger. In Study 2 (N = 174), fear, sadness, and happiness were experimentally induced. Among those induced to experience fear, the positive relation between ITG-DS and prejudice toward Muslims was significantly strengthened relative to control. Overall, specific negative emotions, especially fear, interacted with individual differences in intergroup-relevant disgust sensitivity to inform outgroup evaluations.     

Some Physiological Concomitants of Pursuit Rotor Performance and Reminiscence

A frustration theory of pursuit rotor performance and reminiscence has previously been presented (Costello, 1967; Costello & Discipio, 1967). The theory was reformulated in terms of arousal theory and the following hypotheses were tested: (1) an inverted “U” relationship exists between level of arousal and performance level; (2) reminiscence results when S during the rest period moves closer to his optimum level of arousal; (3) massed practice produces a higher level of arousal than spaced practice; (4) experimental conditions producing a high drive state will also increase his arousal level. Findings in line with these hypotheses were found for EMG measures but not for GSR and pulse rate. In view of what appears to be the task-specific nature of the physiological results it was concluded that there was no particular advantage in reformulating the frustration theory in terms of arousal theory.     

Relations Between Continuous Performance Test Performance Measures and ADHD Behaviors

The Conners' Continuous Performance Test (CPT) is a neuropsychological task that has repeatedly been shown to differentiate ADHD from normal groups. Several variables may be derived from the Conners' CPT including errors of omission and commission, mean hit reaction time(RT), mean hit RT standard error, d', and . What each CPT parameter actually assesses has largely been based upon clinical assumptions and the face validity of each measure (e.g., omission errors measure inattention, commission errors measure impulsivity). This study attempts to examine relations between various CPT variables and phenotypic behaviors so as to better understand the various CPT variables. An epidemiological sample of 817 children was administered the Conners' CPT. Diagnostic interviews were conducted with parents to determine ADHD symptom profiles for all children. Children diagnosed with ADHD had more variable RTs, made more errors of commission and omission, and demonstrated poorer perceptual sensitivity than nondiagnosed children. Regarding specific symptoms, generalized estimating equations (GEE) and ANCOVAs were conducted to determine specific relationships between the 18 DSM-IV ADHD symptoms and 6 CPT parameters. CPT performance measures demonstrated significant relationships to ADHD symptoms but did not demonstrate symptom domain specificity according to a priori assumptions. Overall performance on the two signal detection measures, d' and , was highly related to all ADHD symptoms across symptom domains. Further, increased variability in RTs over time was related to most ADHD symptoms. Finally, it appears that at least 1 CPT variable, mean hit RT, is minimally related to ADHD symptoms as a whole, but does demonstrate some specificity in its link with symptoms of hyperactivity.