Modeling ADHD-type arousal with unilateral frontal cortex damage in rats and beneficial effects of play therapy

It has been recently shown that human adolescents with Attention Deficit/Hyperactivity Disorder (ADHD) have frontal lobe deficits, especially on the right sides of their brains (). ADHD is commonly treated with psychostimulants which may have adverse consequences. Hence, less invasive therapies need to be developed. In the present work, we tested the ability of right frontal lesions to induce hyperactivity in rats. We also evaluated the effects of chronic play therapy during early adolescence to reduce both hyperactivity and the elevated playfulness later in development. Play therapy was able to reduce both hyperactivity and excessive playfulness. In additional work, we found that access to rough-and-tumble play in normal animals could enhance subsequent behavioral indices of behavioral inhibition (i.e., freezing in response to a startle stimulus) that appeared to be independent of increased fearfulness and fatigue. Overall, these results suggest that (1) neonatal frontal lobe lesions can be used as an animal model of the overactivity in ADHD and (2) rough-and-tumble play therapy may be a new useful treatment for ADHD.     

The Effects of Using a Conditioned Stimulus to Cue DRO Schedules

A reversal design was used to examine the effects of a differential reinforcement of other behavior (DRO) procedure and the presence of a stimulus (i.e., a bracelet), conditioned via discrimination training, on reducing socially maintained non‐contextual vocalizations in an adolescent girl with autism. Initially, a functional analysis determined that non‐contextual vocalizations were maintained by social attention. Then, discrimination training was used to establish the presence of the bracelet as a discriminative stimulus for the absence of vocalizations. Specifically, when the bracelet was on, non‐contextual vocalizations were interrupted, and edible reinforcement was provided for the absence of vocalizations. When the bracelet was off, vocalizations were not interrupted and the teacher provided social attention to the participant (i.e., reciprocated conversation with the participant about the topic). During intervention, a DRO procedure was used. The participant was presented with the bracelet, a timer set for a specified interval, and the instruction to work quietly. If vocalizations did not occur for the entire duration of the interval, the bracelet was removed and the learner was given the opportunity to engage in vocalizations. The DRO interval was systematically increased throughout the intervention. Results are discussed in terms of discrimination training as an effective addition to differential reinforcement procedure. Copyright © 2015 John Wiley & Sons, Ltd.     

Post-Adoption Services for High-Risk Families and Their Children: Preliminary Results of a State-Wide Intervention

Despite well-documented post-adoption needs of adoptive families, most states provide no or very limited post-adoption services. This study describes Right Turn® (RT), a state-wide program for strengthening adoptive families and preventing adoption dissolution. Results suggest: (a) RT is serving its targeted audience of adoptive families with challenging problems indicated by older adopted children with a history of multiple placements, extended time in social services systems, and a host of mental health challenges; and (b) adoption training, family support when navigating access to post-adoption services, and collaboration with adoption-competent therapists appeared to have helped improve program outcomes.     

Satisfaction with the Health Care Provider and Regimen Adherence in Minority Youth with Type 1 Diabetes

To assess whether satisfaction with the health-care provider is related to regimen adherence among primarily minority youth with type 1 diabetes. Youth with type 1 diabetes (n = 169; M age = 13.88; 52 % female; 70 % Hispanic) and their parents completed questionnaires that assessed their own satisfaction with the health-care provider and youths’ adherence to diabetes self-care behaviors. Higher youth and parent patient-provider relationship satisfaction was associated with higher regimen adherence. Gender affected the relationship between satisfaction and regimen adherence, such that for girls, greater satisfaction was associated with better adherence; this was not the case for boys. Patient satisfaction with the health care provider is important for regimen adherence among primarily minority youth with type 1 diabetes, particularly for girls. Future research might focus on improving youths’ relationships with their health care providers as a potential pathway to improve regimen adherence.     

Investigating the relationship between working memory and emotion regulation in mothers

Recent work suggests that executive functions, specifically working memory, may facilitate emotion regulation (ER). Here we examined whether measures of visuospatial working memory and verbal working memory relate to ER in a group of recent mothers. We found that while visuospatial working memory was associated with, and predictive of, self-reported measures of ER and emotion dysregulation—verbal working memory was correlated to only one dimension of emotion dysregulation. These findings suggest that working memory may play a unique role in everyday regulatory functioning. We frame our results in terms of the broader implications they may have for the potential role of executive functioning in parenting.     

Use of the Behavioral Assessment System for Children 2nd Edition: Parent Report Scale in Pediatric Cancer Populations

This study examined the use of the Behavioral Assessment System for Children—2nd Edition: Parent Report Scale (BASC-2; Reynolds & Kamphaus, Behavior assessment system for children, 2004) in a pediatric cancer population. Comparisons of scale scores were made between pediatric cancer participants and controls. Within group comparisons were also made between subtypes of pediatric cancer. Parents of 111 children and adolescents who had experienced pediatric cancer completed the BASC-2 as part of larger studies of parent-child adjustment to cancer. Scores on the BASC-2 for cancer survivors were compared to a matched control group. Results from MANOVA analyses revealed that children with cancer were categorized as evidencing more emotional and cognitive complaints compared to the control children. Notably, no significant within group differences emerged on the subscales with regard to cancer subtype. Although preliminary, these results suggest that the BASC-2 can identify the cognitive and emotional differences between cancer survivors and controls.     

Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear

Extinction of conditioned fear is an important model both of inhibitory learning and of behavior therapy for human anxiety disorders. Like other forms of learning, extinction learning is long-lasting and depends on regulated gene expression. Epigenetic mechanisms make an important contribution to persistent changes in gene expression; therefore, in these studies, we have investigated whether epigenetic regulation of gene expression contributes to fear extinction. Since brain-derived neurotrophic factor (BDNF) is crucial for synaptic plasticity and for the maintenance of long-term memory, we examined histone modifications around two BDNF gene promoters after extinction of cued fear, as potential targets of learning-induced epigenetic regulation of gene expression. Valproic acid (VPA), used for some time as an anticonvulsant and a mood stabilizer, modulates the expression of BDNF, and is a histone deacetylase (HDAC) inhibitor. Here, we report that extinction of conditioned fear is accompanied by a significant increase in histone H4 acetylation around the BDNF P4 gene promoter and increases in BDNF exon I and IV mRNA expression in prefrontal cortex, that VPA enhances long-term memory for extinction because of its HDAC inhibitor effects, and that VPA potentiates the effect of weak extinction training on histone H4 acetylation around both the BDNF P1 and P4 gene promoters and on BDNF exon IV mRNA expression. These results suggest a relationship between histone H4 modification, epigenetic regulation of BDNF gene expression, and long-term memory for extinction of conditioned fear. In addition, they suggest that HDAC inhibitors may become a useful pharmacological adjunct to psychotherapy for human anxiety disorders.