2-Deoxy-d-Galactose Effects on Passive Avoidance Memorization in the Rat

2-Deoxy-d-galactose (do-gal) hinders glycoprotein fucosylation. This compound was intracerebroventricularly administered to male adult Wistar rats in order to assess whether it could exert amnesic effects on a passive avoidance response (PAR) to be learned in the light–dark box apparatus. Three experiments were performed. In the first, do-gal was administered immediately after the acquisition trials at three dosages (2, 4, and 8 μmol). It was found that only the 4-μmol dosage was followed by PAR disruption. In the second, do-gal was administered at the adequate dosage (4 μmol) either 30 min before the acquisition trial or 30 min before retrieval testing. It was found that only the preretrieval administration was followed by PAR impairment. In the third, do-gal (4 μmol) was administered in postacquisition, at increasing postacquisition delays (0.25, 1.5, 4, and 6 h). It was found that there was PAR disruption only after do-gal administration at the shortest (0.25 h) delay. The results confirm that in the rat, glycoprotein fucosylation is involved in some of the phases of memory trace processing, and they are discussed in relation to other findings in the rat and the chick.     

Frame multiplicity and policy fiascoes: Limits to explanation

The dynamics of intractability, frame multiplicity and intense controversy not only characterize policy formation struggles, as described by Schön and Rein, but also affect the evaluation of policies and government action. Policy analysts play an important part in the politics of policy evaluation. This article demonstrates that they tend to produce very different explanations for controversial, failing policies. Such differing explanations imply different causal attributions, different allocations of blame, and different lessons for future policy-making. Such differences are not random occurrences; they are embedded in the analytical frames that evaluators use to reconstruct policy processes and to explain their outcomes. It is shown that at least three deep-rooted frames can be reconstructed: fiascoes as failures of public problem solving, fiascoes as institutional imbalances, and fiascoes as system artefacts. One of the great epistemological challenges is how to deal with multiple analytical frames. The final part of the article discusses various strategies.     

Perception of relative pitch with different references: Some absolute-pitch listeners can’t tell musical interval names

Two experiments were conducted to examine the effect of absolute-pitch possession on relativepitch processing. Listeners attempted to identify melodic intervals ranging from a semitone to an octave with different reference tones. Listeners with absolute pitch showed declined performance when the reference was out-of-tune C, out-of-tune E, or F#, relative to when the reference was C. In contrast, listeners who had no absolute pitch maintained relatively high performance in all reference conditions. These results suggest that absolute-pitch listeners are weak in relative-pitch processing and show a tendency to rely on absolute pitch in relative-pitch tasks.     

Mindless reading: Eye-movement characteristics are similar in scanning letter strings and reading texts

The purpose of the present study was to compare the oculomotor behavior of readers scanning meaningful and meaningless materials. Four conditions were used—a normal-text-reading control condition, and three experimental conditions in which the amount of linguistic processing was reduced, either by presenting the subjects with repeated letter strings or by asking the subjects to search for a target letter in texts or letter strings. The results show that global eye-movement characteristics (such as saccade size and fixation duration), as well as local characteristics (such as word-skipping rate, landing site, refixation probability, and refixation position), are very similar in the four conditions. The finding that the eyes are capable of generating an autonomous oculomotor scanning strategy in the absence of any linguistic information to process argues in favor of the idea that such predetermined oculomotor strategies might be an important determinant of eye movements in reading.     

Perceived motion in structure from motion: Pointing responses to the axis of rotation

We investigated the ability to match finger orientation to the direction of the axis of rotation in structure-from-motion displays. Preliminary experiments verified that subjects could accurately use the index finger to report direction. The remainder of the experiments studied the perception of the axis of rotation from full rotations of a group of discrete points, the profiles of a rotating ellipsoid, and two views of a group of discrete points. Subjects’ responses were analyzed by decomposing the pointing responses into their slant and tilt components. Overall, the results indicated that subjects were sensitive to both slant and tilt. However, when the axis of rotation was near the viewing direction, subjects had difficulty reporting tilt with profiles and two views and showed a large bias in their slant judgments with two views and full rotations. These results are not entirely consistent with theoretical predictions. The results, particularly for two views, suggest that additional constraints are used by humans in the recovery of structure from motion.     

Interaction of genetics and separation in canine hyperkinesis and in differential responses to amphetamine

A model of childhood hyperkinesis, using the Telomian-beagle hybrid dog, is described, demonstrating the interactions of genetics and separation in the development of this syndrome and in the favorable responses of some of these dogs to amphetamine. This work represents the collaboration of three laboratories, utilizing chiefly methods of inhibitory training. Inducing separation distress enhanced the resistance to inhibitory training and the favorable responses to amphetamine.     

Response competition effects insame-different judgments

An account ofsame-different discriminations that is based upon a continuous-flow model of visual information processing (C. W. Eriksen & Schultz, 1979) and response competition and inhibition between the responses by which the subject signifies his judgment is presented. We show that a response signifyingsame will on the average be executed faster due to less priming or incipient activation of the competing response,different. In the experiment, the subjects matched letters on the basis of physical identity. The degree of priming ofdifferent responses on same trials and ofsame responses ondifferent trials was manipulated by an extraneous noise letter placed in the display. Latency for judgments onsame trials increased as the feature overlap of noise and target letters decreased. Latencies were shorter ondifferent trials when the noise letter was dissimilar to either target letter than when the noise letter was the same as one of the targets. These results were consistent with the response-competition interpretation.     

Adaptation in distance perception with head-movement parallax serving as the veridical cue

When head-movement parallax functioned as the sole veridical distance cue during exposure to spectacles that altered the eyes’ oculomotor adjustments, sizable adaptation was obtained. This result showed that a discrimination of the distances of 60 and 30 cm can be based on head-movement parallax. Using adaptation in demonstrating that head-movement parallax can serve as a distance cue circumvents the problem that the presence of accommodation normally presents when such a demonstration is attempted. The usual contamination of head-movement parallax with accommodation is avoided, because accommodation is altered by the spectacles and does pot function as a veridical cue along with head-movement parallax.     

Saccade size control in reading: Evidence for the linguistic control hypothesis

In Experiment 1, it is shown that during reading the eye makes larger saccades near long words than near short words. The effects are reduced when the subject’s peripheral vision is diminished by the use of a moving “window” centered on the subject’s fixation point, outside of which letters are replaced by Xs. In Experiment 2, it is shown that even if linguistic predictions are kept constant, the eye tends to make longer jumps when approaching THE than when approaching a three-letter verb. This “THE-skipping” effect is weaker if THE is compared with an auxiliary (HAD, WAS, or ARE) than if it is compared with a less frequently occurring verb (ATE, RAN, MET). It follows that knowledge of the lexicon can combine with information from peripheral vision fast enough to influence saccade size from moment to moment.