Personality features and cognitive level in patients at an early stage of Alzheimer’s disease

In this cross-sectional study, we explored the relationship between premorbid personality and its changes over 5 years, and cognitive deterioration in patients with mild Alzheimer’s disease. The cognitive level of 54 patients was compared with that of 64 control subjects using the Mini Mental State (MMSE). Family members completed the NEO-PI-R (form R) twice, once to evaluate the participants’ current personality and again to assess personality traits as they were remembered to be 5 years earlier. Furthermore, the family filled in the Informant Questionnaire on Cognitive Decline (IQCODE), the Activities of Daily Living (ADL), and the Instrumental Activities of Daily Living (IADL) scales to assess their proxies’ cognitive level and daily living functioning. Regarding the relationship between personality characteristics and cognitive status, we observed trends for premorbid personality and significant links for personality changes in the clinical group. Thus, changes in neuroticism and conscientiousness were associated with cognitive deterioration, whereas decreased openness to experience and conscientiousness over time predicted loss of independence in daily functioning in the clinical group. Our study suggests that premorbid features can be considered as latent traits linked to the neuropathology underlying the disease process, while personality changes are probably the consequences of the pathological process.     

From Online Dating to Online Divorce: An Overview of Couple and Family Relationships Shaped Through Digital Media

From the very early stages of initiating relationships to types of post-break-up behaviors, the internet has the potential to play an influential role in all areas of family and particularly couple relationships. This paper examines how ICTs (“information and communication technology”) can shape such relationships. The impact on the various stages of relationships is systematized (relationship development, couple and family formation, separation) with a special focus on intergenerational opportunities and conflicts associated with modern media usage. Against the background of psychological and media communication theories and psychotherapeutic approaches as well as empirical findings the following topics are considered: (1) Initiation of relationships through ICTs (e.g. meet new partners through online dating); (2) Impact of digital media on relationship development and existing partnerships (e.g. new opportunities and internet-related challenges that have to be faced by couples) (3) Influence of ICTs on separations (e.g. online mediation, getting divorced online). In summary, the role of ICTs in new, existing and separated partnerships and families is multifaceted. An outlook on further developments as well as research desiderata is given.     

The differential role of premotor frontal cortex and basal ganglia in motor sequence learning: evidence from focal basal ganglia lesions

There has been a growing interest in the differential role of various neural structures in implicit learning processes. The goal of our study was to clarify how focal lesions restricted to the basal ganglia interfere with different aspects of implicit visuo-motor sequence learning. A version of the Serial Reaction Time Task (SRTT) of Nissen and Bullemer using a 12-trial sequence was administered. A total of 20 subjects with focal basal ganglia lesions caused by ischemic or hemorrhagic infarction and 20 matched control subjects participated in this study. The results indicate that subjects with focal basal ganglia lesions showed unimpaired implicit learning of a 12-item motor sequence. Subjects with basal ganglia lesions, however, had more difficulties improving their general proficiency with the reaction-time task independent of sequence-specific learning. We observed a tendency toward smaller regional volumes in the cerebellum and left pre-supplementary motor area (pre-SMA) of subjects with basal ganglia lesions. Smaller cerebellar and pre-SMA volumes were related to lower implicit learning performance in the lesion group. The size of lesions in the basal ganglia was not related to sequence-specific implicit learning but had a significant influence on subjects' general proficiency for execution of the reaction-time task. We propose that implicit learning is achieved by a distributed network of cortical and subcortical structures. The basal ganglia seem to be responsible for adjusting to the general requirements of a task rather than for learning specific associations between stimuli that might be accomplished by premotor frontal areas and the cerebellum instead.     

Warmth and contingency and their relationship to maternal attitudes toward parenting

In this study, the authors addressed the question of whether maternal parenting behaviors in terms of sensitivity, warmth, and contingency with respect to small infants were equally represented in attitudes toward parenting. Sixty mothers from central Germany with middle-class socioeconomic backgrounds were videotaped with their 1st born 3-month-old infant in a free-play and a caregiving episode in their home. The different maternal parenting components were behaviorally analyzed. Maternal attitudes toward parenting were assessed with self-report measures. The results showed that behavioral sensitivity was significantly associated with attitudes related to contingency, whereas behavioral warmth and contingency were not associated with maternal attitudes. The authors interpreted differential associations as a reflection of intuitive and explicit parenting strategies, with only sensitivity being explicitly represented.     

Der informierte Trinker – wozu?

Das Schlagwort vom mündigen Patienten macht derzeit die Runde in allen gesundheitspolitischen Diskussionen. Dabei ist nicht ganz klar, ob es sich um ein Einfordern von Patientenrechten auf Information und Mitgestaltung des therapeutischen Prozesses – sowohl auf der individuellen als auch auf der gesellschaftlichen Ebene (Mitspracherecht von Patientenvertretern bei der Planung von gesundheitspolitischen Ma?nahmen, Finanzierung von Therapieprogrammen etc.) – oder eher um das Abschieben von therapeutischer Verantwortung mit dem Hintergedanken, dass sich der Patient ja aussuchen k?nne, für welche Behandlungsmethode er sich entschlie?e, wie intensiv er mitarbeite und wie eigenverantwortlich er therapeutische Empfehlungen umsetze, handelt.     

Post-irradiation annealing behaviour of oxide dispersion strengthened Fe-Cr alloys studied by nanoindentation

ABSTRACT

To study the nature of irradiation-induced nanofeatures in oxide dispersion strengthened (ODS) Fe-Cr alloys, post-irradiation isochronal thermal annealing up to 600°C was performed for ODS Fe-9%Cr and Fe-14%Cr alloys ion-irradiated at 300°C and 500°C. Nanoindentation indicated hardening for all as-irradiated alloys and complete hardness recovery upon post-irradiation annealing. Cross-sectional TEM indicated an irradiation-induced defect band near peak damage mainly consisting of dislocation loops. Candidate mechanisms of recovery were critically evaluated. Shrinkage of loops via capture of thermal vacancies was found to correctly reflect the annealing behaviour of ODS Fe-9Cr irradiated at 300°C.