Between morality and repentance: recapturing "sin" for bioethics.

Distinguishing within "sin" the dimensions of anomia, hamartia, and asthenia makes it possible to analyze in greater detail the contrary manners in which traditional and post-traditional Christianities in this issue of Christian Bioethics endeavor to recapture what was lost when secular bioethics reconstructed the specifically spiritual-context-oriented normative commitments of Christianity in one-dimensionally moral terms. Various post-traditional attempts at securing moral orientation and resources for forgiveness, both of which secular bioethics finds increasingly difficult to provide, are critically reviewed. Their engagement of secular moral concepts and concerns, and even their adoption of an academically philosophical posture and language, is presented as responsible for their failure to adequately preserve what in traditional Christianity would count as prohibited vs. permitted, and advisable vs. non-advisable, or what would allow to resolve "tragic conflicts." The deeper reason for this failure lies in post-traditional Christianity's restricting the Christian life (with its central tension between love and the law) to what can be captured by cognitive categories. As the survey of several traditionally Christian accounts of sin in bioethics makes clear, both moral orientation (along with the resolution of "tragic" conflicts) and the sources of forgiveness are available, once that Christian life is framed in terms of persons' spirit-supported practical involvement in ascesis and liturgy, and once bioethical reflections are situated in the experiential context of such involvement.     

Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer1 knockout mice by recombinant Adeno-associated viral gene delivery of Homer1c

Homer1 belongs to a family of scaffolding proteins that interact with various post-synaptic density proteins including group I metabotropic glutamate receptors (mGluR1/5). Previous research in our laboratory implicates the Homer1c isoform in spatial learning. Homer1 knockout mice (H1-KO) display cognitive impairments, but their synaptic plasticity properties have not been described. Here, we investigated the role of Homer1 in long-term potentiation (LTP) in the hippocampal CA1 region of H1-KO mice in vitro. We found that late-phase LTP elicited by high frequency stimulation (HFS) was impaired, and that the induction and maintenance of theta burst stimulation (TBS) LTP were reduced in H1-KO. To test the hypothesis that Homer1c was sufficient to rescue these LTP deficits, we delivered Homer1c to the hippocampus of H1-KO using recombinant adeno-associated virus (rAAV). We found that rAAV-Homer1c rescued HFS and TBS-LTP in H1-KO animals. Next, we tested whether the LTP rescue by Homer1c was occurring via mGluR1/5. A selective mGluR5 antagonist, but not an mGluR1 antagonist, blocked the Homer1c-induced recovery of late-LTP, suggesting that Homer1c mediates functional effects on plasticity via mGluR5. To investigate the role of Homer1c in spatial learning, we injected rAAV-Homer1c to the hippocampus of H1-KO. We found that rAAV-Homer1c significantly improved H1-KO performance in the Radial Arm Water Maze. These results point to a significant role for Homer1c in synaptic plasticity and learning.     

TEACHING EARLY READING SKILLS TO CHILDREN WITH AUTISM USING MIMIOSPROUT EARLY READING

A number of studies have demonstrated positive outcomes for typical learners from the internet‐based reading program, MimioSprout® Early Reading (MER). In the present study, a preliminary evaluation of MER was conducted with four children with autism who attended an applied behavior analysis educational program in a school setting. The primary aim was to investigate whether it would be feasible to use MER with children with autism and whether any adaptations to the standard teaching procedure would be needed. A secondary aim was to investigate whether completing MER would improve early reading skills. When additional discrete‐trial table top activities were designed to supplement each child's progress, every child was able to complete all 80 lessons and showed similar correct performance to that reported for typically developing learners. Results from a standardized test of reading ability showed an improvement in word recognition reading age for all children from 14 months to more than three years over the 14 weeks of teaching. A follow‐up test showed that gains were maintained eight weeks after the end of the intervention. MER can be successfully used with children with autism and can improve their early reading skills. Copyright © 2013 John Wiley & Sons, Ltd.     

Relation of self-talk frequency to loneliness,need to belong,and health in German adults

This study examined whether individuals with a high need to belong and feelings of loneliness tend to compensate for a lack of social contact by self-talk and whether self-talk prevents negative consequences on their physical and mental health. The sample consisted of 559 adults drawn from the German Sozioland Panel Project. The results of SEM analyses revealed evidence for significant relations of the need to belong and loneliness with the frequency of self-talk. Moreover, the need to belong and loneliness were significantly related to mental and physical health, but loneliness was shown to be more important for the prediction of both health outcomes. Results of moderator analyses indicate that self-talk might be a risk factor for an increased negative correlation between loneliness and mental health. Self-talk, which is supposed to be related to self-awareness, might reinforce the subjective feeling of loneliness and hence have a negative impact on psychological well-being.     

Comparison of different strategies to decrease negative affect and increase positive affect in women with borderline personality disorder

Background

In this study we compared the effect of different emotion regulation strategies on positive and negative emotions in patients with borderline personality disorder.

Methods

Emotion regulation strategies were a distracting task, individual positive memory imagery, individual soothing imagery, and a neutral comparison condition. During two separate sessions, 17 participants watched either neutral or negative movie segments before using these strategies.

Results

All three strategies influenced emotions into a favorable direction as compared to the neutral comparison condition. The positive memory image increased positive emotions significantly stronger than counting colors and distracting.

Discussion

Different strategies seem to have similar effects in decreasing negative emotions. Positive emotions may be affected in particular by positive and soothing imagery techniques.