Estimating individual treatment effects from multiple-baseline data: A Monte Carlo study of multilevel-modeling approaches

While conducting intervention research, researchers and practitioners are often interested in how the intervention functions not only at the group level, but also at the individual level. One way to examine individual treatment effects is through multiple-baseline studies analyzed with multilevel modeling. This analysis allows for the construction of confidence intervals, which are strongly recommended in the reporting guidelines of the American Psychological Association. The purpose of this study was to examine the accuracy of confidence intervals of individual treatment effects obtained from multilevel modeling of multiple-baseline data. Monte Carlo methods were used to examine performance across conditions varying in the number of participants, the number of observations per participant, and the dependency of errors. The accuracy of the confidence intervals depended on the method used, with the greatest accuracy being obtained when multilevel modeling was coupled with the Kenward—Roger method of estimating degrees of freedom.     

The effects of social influence on children's memory reports: the omission and commission error asymmetry

Children in two age groups (7 vs. 12 yrs, N= 174) individually interacted with a stranger and were later interviewed about this event. Right before the interview, each child encountered the stranger once again and he engaged in a conversation where he either suggested that a (central or peripheral) detail originally present in the event had actually not been there or that an originally non-present (central or peripheral) detail had in fact been there. It was hypothesized that the two types of misinformation would result in omission and commission errors respectively. The results showed that the social influence resulted in an asymmetric effect (i.e., more commission than omission errors). Importantly, we also found that the children made more errors with respect to the peripheral detail (a suitcase), compared to the central detail (a passenger). Younger children did not make more errors (neither omission nor commission errors) than older children.     

Centrifugal acceleration to 3Gz is related to increased release of stress hormones and decreased mood in men and women

It has been suggested that the central and peripheral neural processes (CPNP) are affected by gravitational changes. Based on the previous experiments during parabolic flights, central and peripheral changes may not only be due to the changed gravitational forces but also due to neuroendocrine reactions related to the psycho-physiological consequences of gravitational changes. The present study focuses on the interaction of neuroendocrine changes and the physical and mental states after acceleration to three-time terrestrial gravity (3Gz). Eleven participants (29.4+/-5.1 [SD] years (male (n=8): 30+/-5.1 years; female (n=3): 27.7+/-2.1 years) underwent a 15 min acceleration to 3Gz in a human centrifuge. Before and after the acceleration to 3Gz circulating stress hormone concentrations (cortisol, adrenocorticotropic hormone (ACTH), prolactin, epinephrine, norepinephrine) and perceived physical and mental states were recorded. A second control group of 11 participants underwent the same testing procedure in a laboratory session. Serum cortisol concentration during exposure to the centrifugal acceleration increased by 70%, plasma concentration of ACTH increased threefold, prolactin twofold, epinephrine by 70% and norepinephrine by 45%, whereas the perceived physical well-being decreased. These findings demonstrate that psycho-physiological changes have to be regarded as a relevant factor for the changes in CPNP during phases of hypergravity exposure.     

Living with Multiple Endocrine Neoplasia Type 1: Decent Care-Insufficient Medical and Genetic Information A Qualitative Study of MEN 1 Patients in a Swedish Hospital

This qualitative study explores how 29 Swedish patients with Multiple Endocrine Neoplasia type 1 (MEN1) experience living with the condition, appraisal of the clinical follow-up program, and surveys their future expectations. The aim of this study is to build knowledge about this patient group in order to provide optimal care. The participants describe physical, psychological, and social limitations in their daily activities and how these limitations influence quality of life. Our findings indicate that a majority of patients have adjusted to their situation, describing themselves as being healthy despite physical symptoms and treatment. The participants received decent care in the clinical follow-up program, - however, greater effort should be put into patient information. These patients might benefit from genetic counseling. Health professionals involved should recognize their potential impact and influence on a patient’s ability to adjust to these circumstances. Antonovsky`s Sense of Coherence theory is used to discuss these findings.     

Assessment of self-conscious emotions: a Swedish psychometric and structure evaluation of the Test of Self-Conscious Affect (TOSCA)

The Test of Self-Conscious Affect (TOSCA) is a well-established scenario-based questionnaire assessing self-conscious emotions, such as shame and guilt, which have been shown to be differentially associated with a variety of functional, motivational, behavioral and health outcomes. The aim of this study was to evaluate the psychometric properties and internal structure of a Swedish version of TOSCA in a sample of 361 healthy adults. The psychometric properties and internal consistency of the Swedish version were at level with the original US TOSCA version for shame, guilt and detachment. The internal structure of the Swedish version was acceptable for shame, guilt and detachment but contained shortcomings in assessment of externalization.     

A novel technology for investigating the dynamics of infant perseverative reaching

We designed and tested a novel technology that enables us to capture the entire stream of behavior in perseverative reaching tasks. Beyond fitting the criteria of the conventional A-not-B task, the novel technology gives us better access to the core features of perseverative reaching, such as timing, behavior history, and reinforcement. The technology allows us to quantitatively manipulate reinforcement characteristics, to accurately program onsets, delays, and stimulus durations as well as locations and salience of the targets, and to automatically record the number of reaches to each target and compute timing. We did a validation study on this new technology, investigating the influence of a number of novel factors on perseverative reaching. We replicated the A-not-B phenomenon and associated developmental changes. In addition, results demonstrated that the new technology offers insights into infants' behavior beyond the first reaching action. Moreover, data collection is fully automated, yielding precise, quantitative data. Future studies using this technology will capitalize on the salient advantages of this technology to more precisely measure goal-directed actions and understand the development of reaching skill.     

Dissociation between linguistic and nonlinguistic gestural systems: a case for compositionality.

This paper addresses the issue of the separability of disorders of sign language from disorders of gesture and pantomime. The study of a left-lesioned deaf signer presents one of the most striking examples to date of the cleavage between linguistic signs and manual pantomime. The left-hemisphere lesion produced a marked sign language aphasia disrupting both the production and the comprehension of sign language. However, in sharp contrast to the breakdown of sign language, the ability to communicate in nonlinguistic gesture was remarkably spared. This case has important implications for our understanding of the neural mediation of language and gesture. We argue that the differences observed in the fractionation of linguistic versus nonlinguistic gesture reflect differing degrees of compositionality of systems underlying language and gesture. The compositionality hypothesis receives support for the existence of phonemic paraphasias in sign language production, illustrating structural dissolution which is absent in the production of pantomimic gesture. Understanding the neural encoding of compositional motoric systems may lead to a principled anatomical account of the neural separability of language and gesture. This case provides a powerful indication of the left hemisphere's specialization for language-specific functions.