Stakeholders’ Opinions on the Implementation of Pediatric Whole Exome Sequencing: Implications for Informed Consent

Advances in whole genome and whole exome sequencing (WGS/WES) technologies have led to increased availability in clinical settings. Currently, there are few guidelines relating to the process and content of informed consent for WGS/WES, nor to which results should be returned to families. To address this gap, we conducted focus groups to assess the views of professionals, parents, and adolescents for the future implementation of WES. The discussions assessed understanding of the risks and benefits of WES, preferences for the informed consent discussion, process for return of results, and the decision-making role of the pediatric patient. Professional focus group participants included bioethicists, physicians, laboratory directors, and genetic counselors. Parent focus groups included individuals with children who could be offered sequencing due to a potential genetic cause of the child’s condition. On-line discussion groups were conducted with adolescents aged 13–17 who had a possible genetic disorder. We identified discrepancies between professionals and patient groups regarding the process and content of informed consent, preference for return of results, and the role of the child in decision-making. Professional groups were concerned with the uncertainty regarding professional obligations, changing interpretation in genomic medicine, and practical concerns of returning results over time. Parent and adolescent groups focused on patient choice and personal utility of sequencing results. Each group expressed different views on the role of the child in decision-making and return of results. These discrepancies represent potential barriers to informed consent and a challenge for genetic counselors regarding the involvement of pediatric patients in decision-making and return of results discussions.     

Towards international comparative research on the professionalisation of Religious Education

This article calls for international comparative research on the professionalisation of Religious Education (RE). To this end, it provides a rationale for focusing upon the concept of professionalisation and a theoretical justification for international comparative research, particularly identifying its significance in terms of the development of RE in England and Germany. The article outlines a methodology for exploring the concepts of professional knowledge, professional self-organisation and politics and professional development. The proposed methodology involves a systematic analysis of primary documentary sources including: (1) academic and professional journal articles and textbooks; (2) the archives of relevant institutions and organisations; and (3) external evidence, such as inspection and research reports. An analytical case study of two leading journals in each national context, Religion in Education in England and Der Evangelische Erzieher in Germany, in the immediate post-war era is appended to illustrate the benefits of implementing such a methodology across national boundaries.     

Automated Integrative Complexity: Current Challenges and Future Directions

Automating integrative complexity is fraught with many challenges. To address these challenges, we discuss the tension between a specificity approach and a more flexible multiple‐pass approach, the multifaceted nature of the complexity construct, the gold standard for complexity measurement, the difficulty of human scoring and its consequences for automation, and some ways forward for creating the best complexity measurements. In so doing, we present new data demonstrating (1) initial evidence for the validity of a new automated system for measuring two different forms of complexity (elaborative and dialectical), (2) the danger of constructing measurements in a purely ad hoc fashion that ignores prospective testing, (3) human‐to‐computer correspondence is in part a function of human‐to‐human correspondence, (4) human‐to‐computer correspondence increases systematically as one uses tests with larger units of analysis, and (5) the lack of correspondence of different systems (both human and automated) may occur in part because they were designed for different units of analysis.     

Alpha to Omega: A Neurological Analysis of Marital Conflict in a Pilot Study

Although the linkage between health and marriage has been noted (e.g., Hayward and Gorman in Demography 41:87–107. doi:10.1353/dem.2004.0005, 2004; Kaplan and Kronick in J Epidemiol Community Health 60:760–765. doi:10.1136/jech.2005.037606, 2006; Schoenborn in Marital status and health: United States, 1999–2002. Advance data from vital and health statistics. National Center for Health Statistics, Hyattsville, MD, 2004), understanding the connection between neurological and behavioral phenomena in marital relationships has yet to be tackled. This pilot study attempted to address this limitation by analyzing electrical brain activity during a conflict interaction between married couples. Results generally supported the work of Lazarus (Emotion and adaptation. Oxford University Press, Oxford, 1991) and Harmon-Jones et al. (J Pers Soc Psychol 82:610–618. doi:10.1037//0022-3514.82.4.610, 2002); individuals that felt like they were in an action-possible situation revealed relatively higher left hemispheric activity in the frontal region of the brain.     

Associative false consumer memory: effects of need for cognition and encoding task

Two experiments investigated the effects of product–attribute associations on false consumer memory. In both experiments, subjects were presented with sets of related product attributes under incidental encoding conditions. Later, recognition memory was tested with studied attributes, non-studied but associated attributes (critical lures) and non-studied unrelated attributes. In Experiment 1, the effect of Need for Cognition (NFC) was assessed. It was found that individuals high in NFC recognised more presented attributes and falsely recognised more associative critical lures. The increase in both true and associative false memory was accompanied by a greater number of responses that index the retrieval of detailed episodic-like information. Experiment 2, replicated the main findings through an experimental manipulation of the encoding task that required subjects to consider purchase likelihood. Explanations for these findings are considered from the perspective of activation processes and knowledge structures in the form of gist-based representations.     

Individual Differences in Commitment to Value‐Based Beliefs and the Amplification of Perceived Belief Dissimilarity Effects

The commitment to beliefs (CTB) framework (Maxwell‐Smith & Esses, 2012) proposes that there are individual differences in the extent to which people generally follow beliefs that are a reflection of their values. The current research hypothesized that CTB would amplify the effects of perceived belief dissimilarity or incompatibility, such that individuals higher in CTB would display more pronounced reactions to belief‐relevant groups, events, or individuals seen as incompatible with their value‐based beliefs. We tested our hypothesis in three studies that assessed participants' CTB and their perceptions of belief dissimilarity or incompatibility with regard to other religious groups (Study 1), political parties during a national election (Study 2), and their romantic partner (Study 3). CTB amplified the effects of perceived belief dissimilarity or incompatibility on people's biases toward other religious groups, voting intentions and behavior in a national election, and their evaluative and behavioral responses toward their romantic partner. These results collectively suggest that perceptions of belief dissimilarity or incompatibility are particularly important cues for individuals with higher levels of CTB as they encounter other people or events that are relevant to their beliefs.