An fMRI investigation of a novel analogue to the Trail-Making Test

The Trail-Making Test (TMT) is a widely used neuropsychological measure that assesses visuomotor abilities and cognitive flexibility. For the TMT-A condition participants are required to locate and connect numbers (i.e. 1-2-3…) while in the TMT-B condition participants perform the set-shifting task of locating and connecting numbers and letters (i.e. 1-A-2-B…). The TMT-B condition has shown impairments in many clinical populations, particularly schizophrenia patients, but the neurobiological underpinning of the task can be difficult to discern given pragmatic obstacles in adapting the task for neuroimaging. In a behavioural testing experiment we demonstrated a close correspondence between performance on the standard TMT and a novel, computer programmed adaptation of the TMT (pcTMT). The pcTMT was designed for functional magnetic resonance imaging (fMRI) administration and neuroimaging data for this task were obtained in. A whole brain analysis revealed significantly greater activation during the pcTMT-B relative to the pcTMT-A in right inferior/middle frontal cortices, right precentral gyrus, left angular gyrus/left middle temporal gyrus. These results identify the regions that most likely underlie cognitive flexibility during the TMT and are candidate regions underlying the impairment of groups with poor set-shifting abilities.     

患者知情同意权实现的伦理思考与法律保护

随着医学科学的发展,患者的知情同意已是医学实践的一个基本伦理观念和原则,但是,它的实现不仅需要道德规范的约束,而且还需要法律的保护.     

A developmental perspective on bullying

In this paper, we examined the forms and relationship contexts of bullying in adolescence. Using cross‐sectional data, we assessed grade and sex differences in self‐reports of bullying and sexually harassing peers, as well as reports of dating aggression from1896 students from early to late adolescence. Reports of bullying others were highest around the school transition, with lowest levels at the end of high school. Boys reported more bullying and sexual harassment than girls. Sexual harassment of same‐ and opposite‐sex peers increased over the early adolescent years and leveled off in later high‐school years. There were no sex differences in the prevalence of indirect or physical aggression with a dating partner. Adolescents who bullied were at increased risk for the other forms of relationship aggression. These data highlight bullying as a relationship problem and point to the need for prevention programs to curtail the use of power and aggression in adolescent relationships. Aggr. Behav. 32:376–384, 2006. © 2006 Wiley‐Liss, Inc.     

Locke's Theory of Demonstration and Demonstrative Morality

Locke famously claimed that morality was capable of demonstration. But he also refused to provide a system of demonstrative morality. This paper addresses the mismatch between Locke's stated views and his actual philosophical practice. While Locke's claims about demonstrative morality have received a lot of attention it is rare to see them discussed in the context of his general theory of demonstration and his specific discussions of particular demonstrations. This paper explores Locke's general remarks about demonstration as well as his claims about demonstration in natural philosophy, mathematics, and morality. Careful attention to these detailed discussions motivates a reevaluation of Locke's views on demonstrative knowledge of morality. Specifically, while Locke did believe that some demonstrative moral knowledge might be in‐principle available to us he also believed that facts about the difficulty of demonstration meant that this knowledge would in‐practice be largely unattainable.     

Recognition of facial expression and identity in part reflects a common ability,independent of general intelligence and visual short-term memory

Recognising identity and emotion conveyed by the face is important for successful social interactions and has thus been the focus of considerable research. Debate has surrounded the extent to which the mechanisms underpinning face emotion and face identity recognition are distinct or share common processes. Here we use an individual differences approach to address this issue. In a well-powered (N?=?605) and age-diverse sample we used structural equation modelling to assess the association between face emotion recognition and face identity recognition ability. We also sought to assess whether this association (if present) reflected visual short-term memory and/or general intelligence (g). We observed a strong positive correlation (r?=?.52) between face emotion recognition ability and face identity recognition ability. This association was reduced in magnitude but still moderate in size (r?=?.28) and highly significant when controlling for measures of g and visual short-term memory. These results indicate that face emotion and face identity recognition abilities in part share a common processing mechanism. We suggest that face processing ability involves multiple functional components and that modelling the sources of individual differences can offer an important perspective on the relationship between these components.     

Regret in Decision Making

Decision research has only recently started to take seriously the role of emotions in choices and decisions. Regret is the emotion that has received the most attention. In this article, we sample a number of the initial regret studies from psychology and economics, and trace some of the complexities and contradictions to which they led. We then sketch a new theory, decision justification theory (DJT), which synthesizes several apparently conflicting findings. DJT postulates two core components of decision–related regret, one associated with the (comparative) evaluation of the outcome, the other with the feeling of self–blame for having made a poor choice. We reinterpret several existing studies in DJT terms. We then report some new studies that directly tested (and support) DJT, and propose a number of research issues that follow from this new approach to regret.     

The Token Activity: Generating Awareness of Power in Counseling Relationships

The authors present an experiential activity, the token activity, that increases student awareness of power and privilege dynamics. Student feedback is incorporated to offer perceptions and knowledge gained from their experience. Los autores presentan una actividad experiencial, la actividad simbólica, que incrementa la conciencia los estudiantes sobre poder y dinámica de privilegios. Se incluyen las reacciones de los estudiantes para ofrecer las percepciones y el conocimiento que adquirieron durante su experiencia.     

Myopic regret avoidance: Feedback avoidance and learning in repeated decision making

Decision makers can become trapped by myopic regret avoidance in which rejecting feedback to avoid short-term outcome regret (regret associated with counterfactual outcome comparisons) leads to reduced learning and greater long-term regret over continuing poor decisions. In a series of laboratory experiments involving repeated choices among uncertain monetary prospects, participants primed with outcome regret tended to decline feedback, learned the task slowly or not at all, and performed poorly. This pattern was reversed when decision makers were primed with self-blame regret (regret over an unjustified decision). Further, in a final experiment in which task learning was unnecessary, feedback was more often rejected in the self-blame regret condition than in the outcome regret condition. We discuss the findings in terms of a distinction between two regret components, one associated with outcome evaluation, the other with the justifiability of the decision process used in making the choice.     

Comparison of sweat bottle and sweat print measures under resting-state conditions

Palmar sweat measurements were obtained under resting-state conditions using both the newly developed sweat bottle technique and the frequently employed sweat print method. Measurement reliability was high for both approaches. The two methods, at least under generally nonstressful conditions, appear to reflect essentially different aspects of palmar sweating.