Mosaic trisomy 20 and mitigation in capital crimes sentencing: A review and case report

Trisomy 20 is a genetic abnormality in which individuals have an extra copy of chromosome 20. Complete trisomy 20 is rare and believed to be incompatible with life. A mosaic form of trisomy 20, in which only some cells or tissues contain the extra chromosome, is a relatively commonly encountered chromosomal abnormality found during prenatal testing, and c. 90% result in a normal phenotype. However, despite the absence of a consistent phenotype, certain findings have been reported across multiple cases of mosaic trisomy 20. These include an array of morphological findings, developmental delays, and learning disabilities. Beyond physical manifestations, a wide range of developmental and learning delays have also been reported. In this work, we provide an overview of the trisomy 20 literature and a case report of a young adult male with mosaic trisomy 20 who committed homicide. His developmental and life history, eventual diagnosis of mosaic trisomy 20, similarities and differences in his condition compared with prior research findings, and potentially new phenotypic findings associated with trisomy 20 that he manifested (childhood visual hallucinations, self‐injury, polydactyly) are presented. Additionally, the potential role of this genetic diagnosis in his neuropsychiatric history and its successful application as a mitigating factor at his capital sentencing trial are described. We did not identify other similar cases during our search of major scientific and legal databases. As a backdrop, the use of genetics in criminal trials is on the rise, and courts are increasingly likely to accept behavioral genetics evidence; therefore, it is crucial that the legal system is well acquainted with the opportunities and limitations of these approaches.     

从诺贝尔生理与医学奖提名看亚洲的医学地位

诺贝尔生理与医学奖是生命科学领域声誉最高的一个奖项,获得者的多少常被作为衡量一个国家科技实力的一项指标.至今,亚洲的科学家仅有1人获得了该项荣誉,但是已经有多名科学家获得了提名,通过描述从1901年到1951年之间诺贝尔生理与医学奖的提名情况来评价亚洲的医学地位.     

父母教养方式与幼儿焦虑关系的三水平元分析

以0~7岁学前儿童为样本,采用元分析方法考察父母教养方式（积极和消极）与幼儿焦虑之间的关系。通过文献检索,共获得26项研究,含136个独立效应量,被试总数达13565名。由于部分研究中存在多个效应量,当前研究针对两种教养方式分别构建了三级元分析模型。主效应检验发现,父母积极教养方式与幼儿焦虑呈显著负相关,而父母消极教养方式与幼儿焦虑呈显著正相关。调节效应检验发现,父母积极教养方式与幼儿焦虑之间的相关受到父亲受教育水平和幼儿生活质量的调节,但不受幼儿性别、母亲受教育水平和焦虑测量工具类型的影响。此外父母消极教养方式与幼儿焦虑之间的相关受到焦虑测量工具类型的调节,但这一相关不受幼儿性别、生活质量和父母受教育水平的调节。上述结果表明,父母教养方式与幼儿焦虑之间的关系密切,也指出了将来的研究过程中要关注父亲受教育水平、幼儿生活质量和焦虑测量工具类型在两者关系中的作用。     

Actor‐Partner Interdependence Models (APIM) and Voting Behavior: Methodology and Applications

Recently, the social sciences have witnessed a rising interest in dyadic design, as an efficient way to disentangle mechanisms of interpersonal influence. Despite the relevance of this design to political research, few efforts have been made to collect and efficiently analyze dyadic data. In this article, we suggest the Actor‐Partner Interdependence Model as a useful tool to test bidirectional effects in dyadic data on political attitudes and behaviors. The model explicitly assumes that members of a dyad (reciprocally identified as actor and partner) involved in political communication are interdependent and influence each other. We apply the model to estimate the effect of partner's party identification on actor's vote choice, using 1996 Indianapolis–St. Louis dyadic data. Results show that partner's party identification is significantly associated with vote choice. Moreover, we show that influence between dyad members is moderated by their intimacy and that an increased difference in socioeconomic status between dyad members tips the balance of the effect in favor of the individual with more resources. Our conclusions point to the effectiveness of APIM in modeling interdependent asymmetric relations and call for increasing efforts in collecting dyadic data and in developing proper tools for their analysis.     

Biotechnology and the New Right: Neoconservatism's Red Menace

Although the neoconservative movement has come to dominate American conservatism, this movement has its origins in the old Marxist Left. Communists in their younger days, as the founders of neoconservatism, inverted Marxist doctrine by arguing that moral values and not economic forces were the primary movers of history. Yet the neoconservative critique of biotechnology still borrows heavily from Karl Marx and owes more to the German philosopher Martin Heidegger than to the Scottish philosopher and political economist Adam Smith. Loath to identify these sources—or perhaps unaware of them—neoconservatives do not acknowledge these intellectual underpinnings or their implications. Thus, in the final analysis, their critique is incoherent and even internally inconsistent. By not acknowledging and embracing their intellectual roots, neoconservatives are left with a deeply ambivalent and often confused view of biotechnology and the society that gives rise to it.     

The Role of the Family in Promoting Responsible Substance Use in Adolescence

The aim of this study was to examine the role of family dimensions in tobacco, alcohol, and cannabis use among adolescents. Furthermore, we investigated how demographic variables (adolescents’ gender and age) influence substance use and moderate the relationship between family dimensions and substance use. The sample consisted of 14,825 adolescents aged 13–14, 15–16, and 17–18 who participated in the 2006 edition of the Health Behaviour in School-aged Children (HBSC) study in Spain. The HBSC-2006 questionnaire included demographic variables (gender and age), substance use variables (tobacco, alcohol, and cannabis use), and family dimensions (parental affection, parental promotion of autonomy, family activities, adolescent disclosure, parental solicitation, and parental knowledge). The results indicated that adolescent disclosure, family activities, and parental knowledge had a significant effect on substance use. Specifically, maternal variables were shown to be slightly more relevant than paternal variables. Additionally, substance use was higher in older adolescents than in younger adolescents, and boys smoked less than girls. The discussion focused on how family dimensions promoted responsible substance use in adolescence.     

Correlates of Happiness Among Older Spanish Institutionalised and Non-Institutionalised Adults

The overall objective of this study was to explore the current (i.e., at the time of the study) and past (i.e., over their lifetimes) happiness of 65-year-old and older men and women who had different personal and socio-demographic characteristics. We also investigated the role of affect balance and life satisfaction as sources of participants’ subjective well-being, as well as the contribution of other psychosocial variables, including self-efficacy, optimism, health and quality of life, stress, social support and leisure, and of socio-demographic conditions. Further, we examined the influence of institutionalisation on happiness and on the aforementioned psychosocial variables. Participants voluntarily completed self-reports regarding all of these variables. Participants’ current happiness (M = 6.6 on a 0–10 scale) was significantly lower than their past happiness (M = 7.7). The happiness of the institutionalised participants did not differ from that of the non-institutionalised participants, although significant differences were found for a number of psychosocial variables. Affect balance and life satisfaction were significant correlates and predictors of current happiness, which was also associated with many psychosocial variables and was further predicted by past happiness, health indicators and some life dimensions assessed as perceived sources of one’s own happiness, such as a sense of autonomy and independence. Our results highlight the importance of establishing both happiness and its correlates to develop interventions aimed at promoting subjective well-being in older people, given that, compared to earlier periods in life, happiness may be reduced in late adulthood.     

The classification of Spanish adolescents based on substance consumption patterns and the analysis of the relationships within their social developmental contexts

This research is part of the 2006 edition of the Health Behavior in School-aged Children (HBSC) study. The data presented were composed of a sample of 15942 Spanish adolescents ranging from 13 to 18 years of age. The instruments used included a variety of questions related to substance consumption among adolescents, their bio-psycho-social adjustment and developmental contexts, all of which are part of the HBSC study instrument bank. Through classification analysis, as well as significance and effect size tests, we obtained relevant information about the current epidemiology of substance consumption among Spanish adolescents. These results are representative of the Spanish adolescent population which allows the typical risk profile attributed to young people to be clarified. A gradual adjustment can be seen in terms of substance consumption levels in youth and that same level in their friends. Likewise, the analysis of the developmental context (family, friends and school) provides important information when it comes to preventing substance consumption, thus showing the advantages that coherence and connection have between the different environments where youth live, grow up and develop.