Factors Influencing Men's Interest in Gene Testing for Prostate Cancer Susceptibility

Interest in genetic testing for inherited cancer susceptibility is high in the general population. Women at risk for BRCA1 and BRCA2 mutations represent the best-studied population undergoing genetic testing for cancer susceptibility. However, it is unclear whether factors influencing interest in genetic testing in women are directly applicable to men. We designed a study to examine factors associated with men's interest in genetic testing to identify prostate cancer susceptibility. Our sample consisted of 267 men present in waiting rooms of a urology clinic in an urban area. We examined whether the concept of monitoring could be used to predict the interest of men in a genetic test for prostate cancer susceptibility. Our results indicated that monitoring trait was positively associated with interest in genetic testing in these men, but principally for patients rather than nonpatients. Moreover we found that monitoring was associated with over estimation of risk in those men with prostate cancer. Other factors found to influence interest in genetic testing included recommendation by a doctor, family history of prostate cancer, and cost. This study indicated that interest in genetic testing and estimation of risk is influenced by a complex interaction between both psychological factors (monitoring) and nonbehavioral factors (such as patient status, cost, and doctor recommendation).     

Formal Requirements of Markov State Models for Paired Associate Learning

Discrete state learning models that make Markov assumptions are a powerful tool for the analysis and optimization of performance in paired associate tasks. We seek here to derive bounds on the complexity needed by such models in order to account for the critical effects of lag and retention intervals on paired associate learning. More specifically, after establishing that two different Markov chains are needed (one for describing the effects of trials where a paired associate is presented and one for describing the effects of trials where the paired associate is not presented), we determine the minimum number of states required in a Markov model with two chains. It is shown formally that, under certain psychologically plausible assumptions, more than three states are required. A model with two chains and four states is presented and it is shown empirically that it can account for the lag and retention effects in paired associate learning. Copyright 2001 Academic Press.     

Who lives,who dies,who decides: Differences between mass public shooters who survive,are killed,and commit suicide

This study provides an in-depth analysis of American mass public shooting conclusions between 1966 and 2017. Specifically, this work examines differences in factors contributing to the perpetrator's likelihood of surviving, being killed, and committing suicide. Ten hypotheses, rooted in previous homicide, suicide, homicide-suicide, and mass public shooting literature consider different psychological, situational, and background factors shaping the outcome of mass public shootings. Significant findings indicate factors influencing perpetrators' suicide include suicidal ideation, higher victim counts, and suicide copycat effects. Factors influencing perpetrators being killed similarly include higher victim counts, the arrival of law enforcement, lethal/non-lethal resistance, and government targets. This investigation provides practical implications for practitioners and policymakers, especially law enforcement and mental health practitioners, seeking to develop intervention and prevention strategies for addressing suicidal ideation and its most lethal outcome: mass public shootings.     

Basic and applied research on extinction bursts

Discontinuation of the contingency between a response and its reinforcer sometimes produces a temporary increase in the response before its rate decreases, a phenomenon called the extinction burst. Prior clinical and basic studies on the prevalence of the extinction burst provide highly disparate estimates. Existing theories on the extinction burst fail to account for the dynamic nature of this phenomenon, and the basic behavioral processes that control response bursting remain poorly understood. In this paper, we first review the basic and applied literature on the extinction burst. We then describe a recent refinement of the concatenated matching law called the temporally weighted matching law that appears to resolve the above-mentioned issues regarding the extinction burst. We present illustrative translational data based conceptually on the model. Finally, we discuss specific recommendations derived from the temporally weighted matching law regarding procedures clinicians could implement to potentially mitigate or prevent extinction bursts.     

The Curse of Expertise: When More Knowledge Leads to Miscalibrated Explanatory Insight

Does expertise within a domain of knowledge predict accurate self‐assessment of the ability to explain topics in that domain? We find that expertise increases confidence in the ability to explain a wide variety of phenomena. However, this confidence is unwarranted; after actually offering full explanations, people are surprised by the limitations in their understanding. For passive expertise (familiar topics), miscalibration is moderated by education; those with more education are accurate in their self‐assessments (Experiment 1). But when those with more education consider topics related to their area of concentrated study (college major), they also display an illusion of understanding (Experiment 2). This “curse of expertise” is explained by a failure to recognize the amount of detailed information that had been forgotten (Experiment 3). While expertise can sometimes lead to accurate self‐knowledge, it can also create illusions of competence.     

The Responsibilities of Engineers

Knowledge of the responsibilities of engineers is the foundation for answering ethical questions about the work of engineers. This paper defines the responsibilities of engineers by considering what constitutes the nature of engineering as a particular form of activity. Specifically, this paper focuses on the ethical responsibilities of engineers qua engineers. Such responsibilities refer to the duties acquired in virtue of being a member of a group. We examine the practice of engineering, drawing on the idea of practices developed by philosopher Alasdair MacIntyre, and show how the idea of a practice is important for identifying and justifying the responsibilities of engineers. To demonstrate the contribution that knowledge of the responsibilities of engineers makes to engineering ethics, a case study from structural engineering is discussed. The discussion of the failure of the Sleipner A Platform off the coast of Norway in 1991 demonstrates how the responsibilities of engineers can be derived from knowledge of the nature of engineering and its context.