Configuration-specific attentional modulation of flanker- -target lateral interactions

Elements of a contour are often easier to detect when they possess collinearity, with their local orientations matching the global orientation of the contour. We recently reported attentional modulation of such lateral interactions between a central near-threshold target Gabor patch and flanking high-contrast patches (Freeman et al, 2001 Nature Neuroscience 4 1032-1036). Here, we examined whether such attentional effects reflect specific modulation of mechanisms sensitive to collinear configurations, or instead more general modulation of sensitivity to either the global or local orientation-components of the stimulus. Thresholds for detecting a central Gabor target were measured, while observers also judged the Vernier alignment between one pair of flankers and ignored a second flanker pair (when present). Target contrast-thresholds were facilitated only when attending collinear flankers. There was no facilitation when attending flankers that shared only local orientation with the target, or flankers that fell on a global axis aligned with target orientation but having orthogonal local orientation. Ignored collinear flankers had no effect on target thresholds. These results demonstrate strong and specific attentional modulation of contour-integration mechanisms in early vision sensitive to collinear configurations.     

Using the Short Form-36 with multiple sclerosis patients in five countries: a cross-cultural comparison

Questionnaires measuring health-related quality of life are increasingly used in international studies of medical effectiveness. It is important to know if data from these instruments are comparable across countries. We initiated a collaboration among five research groups--from the USA, The Netherlands, Belgium, France, and the UK--in the field of health-related quality of life in multiple sclerosis. All groups used the 36-item Short Form Health Survey. The goal of our study was to make a cross-cultural comparison. In the five countries under study the sample size varied from 50 to 134 patients with multiple sclerosis. The survey was completed by a total of 457 patients, who were heterogeneous in relation to age, duration of illness, severity and type of multiple sclerosis. There appeared to be major differences among the samples in scores on each of the eight scales. These findings may be influenced by differences in method of recruitment, demographic and disease-related characteristics, administration, and cultural factors. After having performed a number of analyses, it appeared that the differences were mainly attributable to sampling effects; however, cultural influences could not be excluded.     

Expression of Fos and Jun Proteins Following Passive Avoidance Training in the Day-Old Chick

It has been shown previously that the immediate-early genes, c-fos and c-jun mRNA are induced in the 1-day-old chick forebrain after one-trial passive avoidance training in which chicks learn to avoid pecking at a bitter-tasting bead. Here, we have studied the expression of their proteins using antibodies to Fos and Jun. Western blotting disclosed two immunoreactive bands for the anti-Fos antibody (47 and 54 kD) and two immunoreactive bands for the anti-Jun antibody (39 and 54 kD). Two hours post-training there was an increase in the number of Fos-positive stained nuclei in right intermediate medial hyperstriatum ventrale (IMHV) (P<0.01), left IMHV (P<0.05), right lobus parolfactorius (LPO) (P<0.025) and left LPO (P<0.05) of birds trained on the bitter bead compared with controls that had pecked a water-coated bead. Staining for Jun protein was significantly greater in the right LPO of trained chicks (P<0.01). Other forebrain regions showed no increase over quiet control levels. The findings are discussed in the context of the cascade of events involved in passive avoidance memory consolidation in the day-old chick.     

The differential impact on carers dealing with clients with challenging behaviours

This study addresses the effects of organizational culture on the ways in which carers in small community homes cope with clients with challenging behaviours. Results indicated that carers socialized in a traditional setting (i.e. large institutions) responded to challenging behaviours by becoming more negative in their attitudes towards clients. Strain levels in carers socialized in the Social Services were related directly to client challenging behaviours, and unrelated to their attitudes which remained positive.     

Personality organization as an aspect of back pain in a medical setting.

The MMPI profiles of 74 low back pain patients who had previously been classified as "functional,"organic," or "mixed" were sorted into six profile groups. The six profile groups were those used by Pichot, Perse, Lekous, Dureau, Perez, and Rychewaert (1972); denial, "conversion V" without defensiveness, "conversion V" with defensiveness, depressed/anxious, psychotic and normal. Results indicate that all six profile types are well represented in the low back pain group. Evidence is also presented which shows that each of the pathological MMPI profile types examined across "functional," "organic," and "mixed" classification is significantly more elevated than a normal profile group on two scales (Lb, DOR) designed to measure functional aspects of pain. Pathological MMPI profile groups did not differ significantly from each other on the "functional" pain scales. The data presented in this study point to the relationship of various forms of psychopathology with "functional pain." The findings of this study would not support a homogeneous "pain personality" for low back pain patients. However, combined "conversion V" profiles accounted for 58% of the "functional" group, 45% of the "mixed" group and 35% of the "organic" group.     

The sex discrimination act and the apu occupational interests guide: A reply to closs

Closs has suggested that the present interest differences between the sexes are a sufficient basis for guidance on career choice. It is doubtful, however, whether the practice of such sexual pre-selection is within either the letter or the spirit of the Sex Discrimination Act. It is accordingly argued that the APU guide is discriminatory and backward-looking. Though statistically excellent, it should not be used in its present form, but should be altered in accordance with contemporary morals and recent legislation.