尼可地尔与前列地尔预处理对大鼠心肌缺血再灌注的影响

研究尼可地尔、前列地尔及两药物联合应用预处理对心肌缺血再灌注中的影响,探究其作用机制.采用Tunel法检测心肌组织的凋亡情况,免疫组化法检测Bax、Bcl-2和caspase-3的蛋白表达情况.结果显示尼可地尔和前列地尔半剂量联合组细胞凋亡数、Bax和caspase-3的表达量均明显低于其他给药组(P＜0.05),Bcl-2的表达量明显高于其他给药组(P＜0.05);尼可地尔和前列地尔单给药组细胞凋亡、Bax、caspase-3表达均有降低,Bcl-2表达升高,但效果不及联合用药半剂量组.以此得出结论尼可地尔和前列地尔的联合用药效果较好,可加强对心肌的保护作用.     

Uncertainty as a Fundamental Scientific Value

The author argues that, though social scientists generally value tolerance for ambiguity, and some even assert a fundamental indeterminacy in human systems, there is still a discipline-wide discomfort with uncertainty and ambiguity. It is argued that this distaste for uncertainty derives from a distorted view of the classical physical sciences, a view that ignores the essentially critical and radical foundations of scientific practice. The drive for certainty, it is argued, is essentially unscientific, in that certain, or adequate, forms of knowledge can only recapitulate the already known and in their dogmatic and institutionalized forms prevent the development of genuinely new knowledge. In contrast, uncertainty is defended as a positive condition, generative of new knowledge because it is open to discovery and to the mystery of the other. The conclusion drawn from this analysis is that the social sciences can only progress if uncertainty, or mystery, is protected and cultivated through a scientific discourse constituted in local and concrete terms (rather than in general and universal ones) and through a self-reflective and self-critical research praxis.     

Assessing Parenting Behaviors in Euro–Canadian and East Asian Immigrant Mothers: Limitations to Observations of Responsiveness

The use of parenting measures that are developed for use with Western families without testing their validity among families from non-Western cultural backgrounds may not be appropriate. Similar parenting behaviors may affect child outcomes in different ways across different cultures. This study examined the cross-cultural validity of an observational Maternal Responsiveness coding system and of self-reports of lax/inconsistent parenting in Euro–Canadian (n = 23) and East Asian immigrant mothers (n = 23) of 4- to 7-year-old sons. In Euro–Canadian mothers, observed parenting responsiveness was associated with less lax/inconsistent parenting and fewer child behavior problems. In East Asian immigrant mothers, however, observations of greater responsiveness were not related to reports of lax/inconsistent parenting, and were associated with greater child behavior problems. Implications for the use of these parenting measures across culture groups are discussed.     

Concerns of Older Veteran Callers to the Veterans Crisis Line

When the Veterans Crisis Line (VCL) was implemented, it was uncertain if veterans, and particularly older male veterans, would utilize the service. We examined VCL use by a growing group of veterans at increased risk for suicide: those aged 60 and older. Real‐time clinical data were gathered from a weekly random sampling of calls. Approximately 25% of calls were from veterans aged 60 or older; over 80% reported benefit from the call. Several significant differences in presenting concerns between older and younger callers were found. Targeted outreach to encourage older veterans to use the VCL is suggested.     

Using the Theory of Gender and Power to Examine Experiences of Partner Violence,Sexual Negotiation,and Risk of HIV/AIDS Among Economically Disadvantaged Women in Southern India

This article uses the Theory of Gender and Power to examine women's vulnerability to HIV/AIDS in order to: understand the vulnerability of female sex workers/poor women due to poverty and lack of educational resources; explore women's vulnerability in the context of client/partner violence, alcohol use, male partner's high-risk behaviors, and women's lack of control in their intimate relationships; and explore the role of traditional heterosexual gender norms in the outcomes of sexual negotiation. Ethnographic data were collected from 32 women and 38 men in India as part of an ongoing National Institute of Mental Health study. Results highlighted women's vulnerability to HIV/AIDS stemming from partner violence, alcohol use, poverty, dangers of sex work environments, and tacit acceptance of cultural/gender norms.     

Suicidality in Bipolar Disorder: The Role of Emotion‐Triggered Impulsivity

A growing body of research suggests that impulsive responses to emotion more robustly predict suicidality than do other forms of impulsivity. This issue has not yet been examined within bipolar disorder, however. Participants diagnosed with bipolar I disorder (n = 133) and control participants (n = 110) diagnosed with no mood or psychotic disorder completed self‐report measures of emotion‐triggered impulsivity (Negative and Positive Urgency Scales) and interviews concerning lifetime suicidality. Analyses examined the effects of emotion‐triggered impulsivity alone and in combination with gender, age of onset, depression severity, comorbid anxiety, comorbid substance use, and medication. A history of suicide ideation and attempts, as well as self‐harm, were significantly more common in the bipolar disorder group compared with the control group. Impulsive responses to positive emotions related to suicide ideation, attempts, and self‐harm within the bipolar group. Findings extend research on the importance of emotion‐triggered impulsivity to a broad range of key outcomes within bipolar disorder. The discussion focuses on limitations and potential clinical implications.     

Youth Responses to Anti‐Smoking Advertisements From Tobacco‐Control Agencies,Tobacco Companies,and Pharmaceutical Companies1

Emotional reactions to anti‐smoking advertising (e.g., fear, sadness, anger) may play an important role in promoting smoking‐related attitudinal and behavioral change. Overall, 278 youth completed response ratings of 16 different elements of 50 anti‐smoking ads made by tobacco‐control agencies, tobacco companies, and pharmaceutical companies. Compared with tobacco‐control ads, tobacco‐company ads were more likely to elicit positive emotions and less likely to elicit negative emotions and to be of interest to youth. Compared with tobacco‐control ads, pharmaceutical company ads were less likely to elicit negative emotional responses or cognitively engage youth and more likely to elicit positive emotions. These findings suggest that youth may be unlikely to respond to tobacco‐company advertising in ways that may lead to a lower likelihood of smoking.     

Conjunction in simulated railway signals: a cautionary note

Train drivers routinely perform visual search tasks to locate combinations of coloured signals controlling their progress, and are required to make discrete decisions on the basis of what they see. Two studies are reported which examine the performance of students under conditions that simulate critical aspects of United Kingdom train drivers' signal‐response task. The most crucial cautionary signal, the single yellow signal used to alert a transition to potentially hazardous situations, was responded to more slowly than other signal types. A longer processing time was found whether (Study 2) or not (Study 1) the signal appearance was accompanied by the auditory warning signal train drivers encounter under actual driving conditions. The results are consistent with predictions from Treisman and Gelade's ( 1980 ) Feature Integration Theory, and the implications for signal sighting practice are discussed. Copyright © 2005 John Wiley & Sons, Ltd.     

Atomangst

Utilizing complex statistical analyses, namely latent growth modeling, the long-term development of worries among peace movement supporters is examined. Data originate from a 7-wave German longitudinal study started in 1985 with the then on average 14-year-old subjects. Waves were interspersed at 3? year intervals. Activists are assumed to have lower (self-related) microworries (H1) and higher macroworries (concerned with larger entities; H2) than non-activists at the onset of the study. Non-activists who appraised the threat of nuclear war as high in 1985 are assumed to report worse mental health than their activist age mates 21 years later (H3). Activists are assumed to express relatively more macroworries than non-activists in mid-adulthood (H4). All four hypotheses were confirmed. Results are interpreted as evidence for the psychoanalytic argumentation by Leith?user that fear of global threats is likely to be displaced into personal anxiety if not coped with in the form of ??identifying participation?? in political action, suggesting that refraining from acting out against a perceived sociopolitical threat is a long-term risk for a positive mental-health trajectory.