Preliminary Evidence for Associations of CHRM2 with Substance Use and Disinhibition in Adolescence

Evidence for shared heritable influences across domains of substance use suggests that some genetic variants influence broad risk for externalizing behaviors. Theories of externalizing psychopathology also suggest that genetic liability for substance use manifests as temperamental risk factors, particularly those related to behavioral disinhibition, during adolescence. The cholinergic muscarinic receptor 2 gene (CHRM2) is a promising candidate for studying genetic influences on broad-based risk for externalizing traits. This study examined a candidate CHRM2 polymorphism (rs1455858) in relation to substance use and personality measures of disinhibition in a sample of high-risk adolescents (n?=?124). Bivariate analyses and structural equation modeling (SEM) evaluated associations of rs1455858 with measures of drug involvement (alcohol, tobacco and marijuana) and disinhibition (indexed by impulsivity and sensation seeking scores). Bivariate analyses showed significant associations of CHRM2 with several behavioral phenotypes. In SEM analyses CHRM2 related significantly to latent measures of substance use and disinhibition; additionally, disinhibition mediated the association of CHRM2 with substance use. These results suggest that CHRM2 variants are potentially relevant for adolescent substance use and that temperamental risk factors could contribute to these associations.     

Clever homunculus: is there an endogenous act of control in the explicit task-cuing procedure?

Does the explicit task-cuing procedure require an endogenous a act of control? In 5 experiments, cues indicating which task to perform preceded targets by several stimulus onset asynchronies (SOAs). Two models were developed to account for changes in reaction time (RT) with SOA. Model 1 assumed an endogenous act of task switching for cue alterations but not for cue repetitions. Model 2 assumed no such act. In Experiments 1 and 2, the cue was masked or not masked. Masking interacted underadditively with repetition and alternation, consistent with Model 2 but not Model 1. In Experiments 3 and 4, 2 cues were used for each task. RT was slower for task repetition than for cue repetition and about the same as RT for task alternation, consistent with Model 2 but not Model 1. The results suggest that the explicit task-cuing procedure does not require an endogenous act of control.     

Organization, development and function of complex brain networks

Recent research has revealed general principles in the structural and functional organization of complex networks which are shared by various natural, social and technological systems. This review examines these principles as applied to the organization, development and function of complex brain networks. Specifically, we examine the structural properties of large-scale anatomical and functional brain networks and discuss how they might arise in the course of network growth and rewiring. Moreover, we examine the relationship between the structural substrate of neuroanatomy and more dynamic functional and effective connectivity patterns that underlie human cognition. We suggest that network analysis offers new fundamental insights into global and integrative aspects of brain function, including the origin of flexible and coherent cognitive states within the neural architecture.     

How Women’s Nonconscious Association of Sex with Submission Relates to Their Subjective Sexual Arousability and Ability to Reach Orgasm

Common cultural stereotypes promote women’s submission to men, especially within intimate heterosexual relationships. Mirroring these stereotypes, women possess nonconscious associations between sex and submission (Sanchez, Kiefer & Ybarra, 2006). Moreover, women’s sex-submission associations predict greater reports of engagement in submissive sexual behavior (Sanchez et al., 2006). In the present research, we again found that women associate sex with submission at a nonconscious level. Study 1 showed that women’s nonconscious sex-submission associations predict reduced subjective arousability. Study 2 further demonstrated that these associations predict impaired ability to reach orgasm among women. These findings suggest that sex-submission associations may adversely affect women’s sexual functioning.     

Training Parents in Forgiving and Reconciling

Teaching parents how to forgive transgressions of parenting partners may reduce negative emotions, increase positive emotions, and, thus, decrease parenting stress. We implemented a waiting-list design to investigate the efficacy of a 9-hour psychoeducational group intervention, Forgiveness and Reconciliation through Experiencing Empathy (FREE), presented to 27 parents and caregivers of children 0–9 years old. Participants receiving FREE exhibited increased forgiveness of a target offense by the parenting partner and increased forgiveness of all parenting offenses. This study offers initial evidence that an intervention to promote forgiveness and reconciliation in parents could be beneficial and might improve parenting relations.     

Managing Retirement—Rethinking Links between Individual and Organization

Retirement represents an important life event in Western countries marking the transition from one life stage to another and the movement from being within to being outside the labour force. For employees, retirement might represent the border between organizational life and life outside the workplace. This border, though commonly thought of as fixed and distinct, is becoming more and more blurred. Organizations and organizational psychology have thus far largely ignored retirement as a relevant topic. However, the changing nature of retirement, as a consequence of demographic changes and developments in the labour market, means that we need to rethink our assumptions about retirement and to attempt to specify some of the missing links between individual and organizational perspectives on retirement. We will argue that retirement is not only an important event in the life of working individuals but has become an important issue for management. This article will discuss some individual retirement processes and possible impacts of retirement on the organization focusing, in particular, on the use of early retirement schemes as a management tool replacing traditional redundancies. It is suggested that these early retirement schemes neglect some basic aspects of individual and organizational retirement processes and are likely therefore in some cases to be less than effective. By describing a different model for managing retirement we aim to suggest how a better balance between individual and organizational needs can be achieved.     

Alkoholabhängigkeit in der psychiatrischen Klinik

In Germany 2.4?% of the population suffer from alcohol dependency and 3.8?% of adults from alcohol abuse. Despite an extensive number of options available for addiction therapy only a minority of affected persons receive addiction-specific therapy. This results in a chronification of the disease and a reduction of approximately 15 years in life expectancy. Background knowledge of the foundations of alcohol addiction leads to a new understanding of the processual course of the disease as well as to new therapy interventions. Individualized treatment includes a combination of outpatient, partial inpatient or inpatient therapeutic measures and range from medical advice for reduction of alcohol consumption, to qualified withdrawal treatment up to pharmacological relapse prophylaxis and long-term weaning treatment. Under current therapeutic conditions abstinence quotas of 50-70?% over 1 year can be achieved. Treating physicians must have sufficient diagnostic certainty and furthermore must be in command of motivating discourse techniques, knowledge on the therapeutic options of outpatient and inpatient withdrawal treatment, pharmaceutical relapse prophylaxis and mediation in rehabilitation measures.     

Independent priming of location and color in identification of briefly presented letters

Attention shifts are facilitated if the items to be attended remain the same across trials. Some researchers argue that this priming effect is perceptual, whereas others propose that priming is postperceptual, involving facilitated response selection. The experimental findings have not been consistent regarding the roles of variables such as task difficulty, response repetition, expectancies, and decision-making. Position priming, when repetition of a target position facilitates responses on a subsequent trial, is another source of disagreement among researchers. Experimental results have likewise been inconsistent as to whether position priming is dependent on the repetition of target features or has an independent effect on attention shifts. We attempted to isolate the perceptual components of priming by presenting brief (10–180 ms) search arrays to eight healthy observers. The task was to identify a color-singleton letter among distractors. All stimulus presentation contingencies were randomized, and responses were unspeeded, to avoid effects of observer expectation and postperceptual effects. Repeating target color and/or position strongly improved performance. The effects of color and position repetition were independent of one another and were stable across participants. The results argue for a strong perceptual component in priming, which biases selection toward recent target features and positions, showing that perceptual mechanisms are sufficient to produce priming in visual search and that such effects can be elicited with limited sensory evidence. The results are the first to demonstrate independent priming of color and position in the identification of briefly presented, postmasked stimuli.     

Controlling the unconscious: attentional task sets modulate subliminal semantic and visuomotor processes differentially

Are unconscious processes susceptible to attentional influences? In two subliminal priming experiments, we investigated whether task sets differentially modulate the sensitivity of unconscious processing pathways. We developed a novel procedure for masked semantic priming of words (Experiment 1) and masked visuomotor priming of geometrical shapes (Experiment 2). Before presentation of the masked prime, participants performed an induction task in which they attended to either semantic or perceptual object features designed to activate a semantic or perceptual task set, respectively. Behavioral and electrophysiological effects showed that the induction tasks differentially modulated subliminal priming: Semantic priming, which involves access to conceptual meaning, was found after the semantic induction task but not after the perceptual induction task. Visuomotor priming was observed after the perceptual induction task but not after the semantic induction task. These results demonstrate that unconscious cognition is influenced by attentional control. Unconscious processes in perceptual and semantic processing streams are coordinated congruently with higher-level action goals.