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The role of dopamine (DA) in rewarding motivated actions is well established but its role in learning how to avoid aversive events is still controversial. Here we tested the role of D2-like DA receptors in the nucleus accumbens (NAc) and the dorsolateral striatum (DLS) of rats in the learning and performance of conditioned avoidance responses (CAR). Adult male Wistar rats received systemic, intra-NAc or intra-DLS (pre- or post-training) administration of a D2-like receptor agonist (quinpirole) or antagonist ((−)sulpiride) and were given two sessions in the two-way active avoidance task. The main effects observed were: (i) sulpiride and lower (likely pre-synaptic) doses of quinpirole decreased the number of CARs and increased the number of escape failures; (ii) higher doses of quinpirole (likely post-synaptic) increased inter-trial crossings and failures; (iii) pre-training administration of sulpiride decreased the number of CARs in both training and test sessions when infused into the NAc, but this effect was observed only in the test session when it was infused into the DLS; (iv) post-training administration of sulpiride decreased CARs in the test session when infused into the NAc but not DLS. These findings suggest that activation of D2 receptors in the NAc is critical for fast adaptation to responding to unconditioned and conditioned aversive stimuli while activation of these receptors in the DLS is needed for a slower learning of how to respond to the same stimuli based on previous experiences. 相似文献
113.
Whether personality differences exist between populations is a controversial question. Even though such differences can be measured, it is still not clear whether they are due to individual phenotypic responses to the environment or whether they have a genetic influence. In a population survey we compared the personality traits of inhabitants of an Italian archipelago (the three Egadi islands; N = 622) with those of the closest mainland population (Trapani area; N = 106) and we found that personality differences between small populations can be detected. Islanders scored significantly lower on the personality traits of openness to experience and extraversion and higher on conscientiousness. We suggest that these personality trait differences could be an adaptive response to a confined socio‐environmental niche, genetically produced by a strong, non‐random gene flow in the last 20–25 generations, rather than the flexible response of islanders to environmental variables. To test this hypothesis, we compared subsets of the islander population classified by ancestry, birthplace, immigration and emigration and found that differences in extraversion can be accounted for by gene flow, while openness to experience and conscientiousness can also be accounted for by some gene–environment interactions. We propose a Personality Gene Flow hypothesis suggesting that, in small isolated communities, whenever there is strong, non‐random emigration, paired with weak and random immigration, we can expect rapid genetic personality change within the population. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
114.
Claudio A. Policastro Andre C.P.L.F. Carvalho Alexandre C.B. Delbem 《Journal of Applied Logic》2006,4(1):26-38
When Case Based Reasoning systems are applied to real-world problems, the retrieved solutions usually require adaptations in order to be used on new contexts. Therefore, case adaptation is a desirable capability. However, case adaptation is still a challenge for this research area. In general, the acquisition of knowledge for case adaptation is harder than the acquisition of cases. This paper explores the automatic learning of adaptation knowledge and explores the use of a hybrid committee approach for automatic case adaptation. 相似文献
115.
Hopkins WD Cantalupo C Wesley MJ Hostetter AB Pilcher DL 《Journal of experimental psychology. General》2002,131(3):412-423
Three experiments on grip morphology and hand use were conducted in a sample of chimpanzees. In Experiment 1, grip morphology when grasping food items was recorded, and it was found that subjects who adopted a precision grip were more right-handed than chimpanzees using other grips. In Experiment 2, the effect of food type on grasping was assessed. Smaller food items elicited significantly more precision grips for the right hand. In Experiment 3, error rates in grasping foods were compared between the left and right hands. Significantly more errors were made for the left compared with the right hand. The cumulative results indicate that chimpanzees show a left-hemisphere asymmetry in motor skill that is associated with the use of precision grips. 相似文献
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Fifty-four individuals with a high degree of religiosity, 47 with a medium degree of religiosity and 64 with low religiosity completed anonymously the Italian versions of well-established measures of obsessive-compulsive (OC) cognitions and symptoms, depression and anxiety. After controlling for anxiety and depression, religious groups scored higher than individuals with a low degree of religiosity on measures of obsessionality, overimportance of thoughts, control of thoughts, perfectionism and responsibility. Moreover, measures of control of thoughts and overimportance of thoughts were associated with OC symptoms only in religious subjects. It is concluded that religion might play a role in obsessive-compulsive disorder phenomenology. Additional research is warranted because it is plausible that only a few aspects of religious teachings (e.g., inflexibility and prohibition) are linked to OC phenomena. 相似文献
119.
This study investigates the performance of two Italian nonfluent aphasic patients on noun-adjective agreement in compounds and in noun phrases. A completion, a reading, and a repetition task were administered. Results show that both patients were able to correctly inflect adjectives within compounds, but not in noun phrases. Moreover, they were sensitive to constituent order (noun-adjective vs adjective-noun) within noun phrases, but less so within compounds. These results suggest differential processing for compounds as compared to noun phrases: While the latter require standard morphosyntactic operations that are often impaired in aphasic patients, the former can be accessed as whole words at the lexical level. 相似文献
120.
Arrindell WA Eisemann M Richter J Oei TP Caballo VE van der Ende J Sanavio E Bagés N Feldman L Torres B Sica C Iwawaki S Hatzichristou C;Cultural Clinical Psychology Study Group 《Behaviour research and therapy》2003,41(7):795-807
Hofstede's dimension of national culture termed Masculinity-Femininity [. Cultures and organizations: software of the mind. London: McGraw-Hill] is proposed to be of relevance for understanding national-level differences in self-assessed agoraphobic fears. This prediction is based on the classical work of Fodor [. In: V. Franks & V. Burtle (Eds.), Women in therapy: new psychotherapies for a changing society. New York: Brunner/Mazel]. A unique data set comprising 11 countries (total N=5491 students) provided the opportunity of scrutinizing this issue. It was hypothesized and found that national Masculinity (the degree to which cultures delineate sex roles, with masculine or tough societies making clearer differentiations between the sexes than feminine or modest societies do) would correlate positively with national agoraphobic fear levels (as assessed with the Fear Survey Schedule-III). Following the correction for sex and age differences across national samples, a significant and large effect-sized national-level (ecological) r=+0.67 (P=0.01) was found. A highly feminine society such as Sweden had the lowest, whereas the champion among the masculine societies, Japan, had the highest national Agoraphobic fear score. 相似文献