Psychosocial risk factors, natural immunity, and cancer progression: Implications for intervention

One of the more important and emerging fields in which psychologists collaborate with other disciplines is psychoimmunology. Centuries of clinical anecdote and decades of psychosomatic hypotheses have gained credibility in the eyes of the medical establishment—and many patients—by the systematic investigation of mechanisms potentially explaining how events intrapsychic and interpersonal could affect physical disease processes. The central nervous system is connected with the immune system by both neuronal and endocrinological pathways. The immune system has been found to mediate the organism’s response to aberrations of its own normal functions, as well as to invading organisms from without. AIDS, arthritis, asthma, lupus, and herpes are some of the illnesses in which research is demonstrating important relationships among psychosocial and immunological factors and disease course. In this article, we first discuss the immunological apparatus in order to provide a base for subsequent discussions of the effects of stress on immune function. Then we discuss malignant diseases and current evidence that disease course is related to both psychosocial stressors and immune function. We next discuss a model of these interactions, and finally we talk about interventions incorporating psychosocial factors aimed at influencing immune status and, thus, disease course.     

The influence of individual and family characteristics upon career aspirations of girls during childhood and adolescence

The term pioneer is used for girls aspiring to male-dominated careers. This longitudinal study assesses the career choices of 68 middle-class girls during childhood (8–13 years, Phase I) and again during adolescence (13–18 years, Phase II), and investigates the relation between pioneering career choice and personal and family characteristics. Subjects were originally selected for exposure vs nonexposure to exogenous hormones during pregnancy. In childhood, pioneers were somewhat older, were more often persistent tomboys, had higher IQs, and had parents with higher educational attainment. In adolescence, paternal education was the only variable that showed the same relation to career choice. Adolescent girls who had wanted to get married at the time of the childhood assessment were now less likely to choose pioneering careers. Adolescent pioneers also had higher educational aspirations than nonpioneers and less likely anticipated being married within ten years than nonpioneers. A number of statistically borderline relationships were also observed: pioneers had somewhat fewer older brothers than nonpioneers, less often came from homes in which traditional femininity was stressed, and more frequently had mothers who had worked outside the home throughout their daughters' school years than mothers of nonpioneers. Prenatal exposure to exogenous sex hormones was not related to career choice during either childhood or adolescence.     

Simulation study of a decision-making model of squash competition, phase two: Testing the model through the use of computer simulation

This study aims at verifying the inner validity and logic of a squash competition decision-making model through the use of computer simulation. The model defines the cognitive-decisional strategy of the defending player (D) when selecting a motor reaction in response to his opponent's shot. Computer simulation of the model was carried out on a PDP-10 computer using a recent version of UCI-LISP. Protocol analysis data pertaining to the nature of the information D processes when awaiting the attacking player's shot were fed into the simulation program in order to examine the extent to which the model can reproduce decisions reached in various defensive contexts. Simulation results reveal that the proposed model can account for a substantial part of the variation in the speed and accuracy of D's motor reaction in real sport situations. Several factors like time pressure, expectancies, uncertainty, recency and familiarity of the relationship between signal and response appear to affect D's motor response via the cognitive-decisional strategy employed by the defending player. Particular discrepancies observed between simulation results and decisions reached by expert players in specific defensive situations nevertheless indicate that the decision rule utilized within the present model needs to be refined. In this regard, several issues are discussed and suggestions for further simulation studies are put forward in order to account more precisely for the various features characterizing the defensive player's motor reaction in real sporting context.     

Case Study: New Directions For the College Counselor at CCNY

Community mental health concepts suggest that college counselors may move towards preventive activity rather than remaining focused primarily on response to established symptoms in troubled students. Preventive activity views the college, its policies, and its administration as legitimate areas of counselor-involvement. Experience indicates there is room on the campus for both functions: (a) traditional one-to-one interactions within the counseling office; and (b) outreach programs affecting large numbers of students and administrators. Outreach has shown itself effective in reaching students who might not spontaneously seek out the counseling office. Several areas of counselor involvement at City College in which the staff has experimented with the outreach philosophy are discussed.     

A REPLY TO JASPER HOLLEY'S DEFENSE OF THE G INDEX

Holley argues that the appearance of effects related to person means in the factor analysis of G indices is due to Levy's failure to adopt the procedure of 'double extending' the score matrix in Q analysis. Holley also points out that this same procedure has no effect upon the G indices. Therefore there is no argument and Levy's results and conclusions stand unaltered.     

Distractor clustering enhances detection speed and accuracy during selective listening

The effects of distractor clustering on target detection were examined in two experiments in which subjects attended to binaural tone bursts of one frequency while ignoring distracting tones of two competing frequencies. The subjects pressed a button in response to occasional target tones of longer duration (Experiment 1) or increased loudness (Experiment 2). In evenly spaced conditions, attended and distractor frequencies differed by 6 and 12 semitones, respectively (e.g., 2096-Hz targets vs. 1482- and 1048-Hz distractors). In clustered conditions, distractor frequencies were grouped; attended tones differed from the distractors by 6 and 7 semitones, respectively (e.g., 2096-Hz targets vs. 1482- and 1400-Hz distractors). The tones were presented in randomized sequences at fixed or random stimulus onset asynchronies (SOAs). In both experiments, clustering of the unattended frequencies improved the detectability of targets and speeded target reaction times, Similar effects were found at fixed and variable SO As. Results from the analysis of stimulus sequence suggest that clustering improved performance primarily by reducing the interference caused by distractors that immediately preceded the target.     

Deconstructing the declaration: A case study in pragrammatology

I would like to thank Jonathan Lee, Terry Pinkard, Steven S. Schwarzschild, Jill Petzall, Bob Gibbs, Bill Hamrick and Jim Bohman for their very helpful criticisms of earlier drafts of this paper.     

In Vivo Hippocampal Acetylcholine Release During Exposure to Acute Stress

Hippocampal extracellular acetylcholine (ACh) and choline levels were evaluated using in vivo microdialysis in male Fischer 344 rats before, during, and following an 80-min exposure to two different stress conditions. Measurements were taken in rats restrained and immersed in a water bath containing either 37 degreesC (normothermic-restraint) or 20 degreesC (cold-restraint) water. Results were compared to normothermic-freely-moving rats. Cold-restrained rats displayed decreased ACh levels during cold exposure relative to both normothermic-restrained and normothermic-freely-moving rats. By the end of the cold exposure period and following removal from cold, ACh levels had returned to near-baseline values. Normothermic-restrained rats had levels similar to those of normothermic-freely-moving rats, except for a marked increase in ACh following removal from restraint. Cold-restrained rats displayed a gradual elevation in choline levels during cold stress, followed by a gradual decline after stress termination, whereas both normothermic-restrained and normothermic-freely-moving rats displayed gradual decreases during the microdialysis session. These findings demonstrate that central cholinergic neurotransmission can be altered by the application of, and removal from, acute stressors. In addition, the results suggest a possible relationship between the magnitudes of both the stressor and its cholinergic consequences.