Communication of Information about Genetic Risks: Putting Families at the Center

Genetic information is a family affair. With the expansion of genomic technologies, many new causal genes and variants have been established and the potential for molecular diagnoses increased, with implications not only for patients but also their relatives. The need for genetic counseling and intrafamilial circulation of information on genetic risks grew accordingly. Also, the amount and, particularly, the complexity of the information to convey multiplied. Sharing information about genetic risks with family members, however, has never been an easy matter and often becomes a source of personal and familial conflicts and distress. Ethical requisites generally prevent healthcare professionals from directly contacting their consultands' relatives (affected or still at risk), who often feel unsupported throughout that process. We discuss here the communication of genetic risks to family members. We first consider genomic testing as a basis for family‐centered health care, as opposed to a predominant focus on the individual. We reviewed the literature on sharing genetic risk information with family members, and the associated ethical issues for professionals. Some clinical cases are presented and discussed, and key issues for meeting the needs of individuals and families are addressed. We argue that genetic information is inextricably linked to the family and that communicating about genetic risks is a process grounded within the broader milieu of family relationships and functioning. We conclude for the need for a more family‐centered approach and interventions that can promote sensitive attitudes to the provision of genetic information to and within the family, as well as its inclusion in educational and training programmes for genetic healthcare professionals.     

Birth Weight and Childhood Psychopathology in the ABCD Cohort: Association is Strongest for Attention Problems and is Moderated by Sex

Research on Child and Adolescent Psychopathology - Many studies have shown low birth weight is associated with psychopathology later in life, particularly attention-deficit/hyperactivity disorder...     

Getting ready: Results of a randomized trial of a relationship‐focused intervention on the parent–infant relationship in rural early head start

The purpose of this study is to investigate the effects of a relational intervention (the Getting Ready intervention) on parenting behaviors supporting the parent–infant relationship for families enrolled in Early Head Start home‐based programming. Two‐hundred thirty‐four parents and their children participated in the randomized study, with 42% of parents reporting education of less than a high‐school diploma. Brief, semistructured parent–child interaction tasks were videotaped every 4 months over a16‐month intervention period. Observational codes of parent–infant relationship behaviors included quality of three parental behaviors: warmth and sensitivity, support for learning, and encouragement of autonomy; two appropriateness indicators: support for learning and guidance/directives; and one amount indicator: constructive behaviors. Parents who participated in the Getting Ready intervention demonstrated higher quality interactions with their children that included enhanced quality of warmth and sensitivity, and support for their children's autonomy than did parents in the control group. They also were more likely to use appropriate directives with their children and more likely to demonstrate appropriate supports for their young children's learning. Results indicate an added value of the Getting Ready intervention for Early Head Start home‐based programming for families of infants and toddlers.     

Peripheral oxytocin administration buffers autonomic but not behavioral responses to environmental stressors in isolated prairie voles

Negative social experiences such as social stressors and isolation influence mental and physical illnesses, including affective disorders and heart disease. Studies focused on socially monogamous prairie voles can provide insight into neurobiological systems that underlie the consequences of negative social interactions. Female prairie voles were exposed to 28 days of social isolation or pairing with a female sibling (control). Voles were administered daily oxytocin [20 μg/50 μl, subcutaneous (sc)] or saline vehicle (50 μl, sc) for 14 days and exposed to two behavioral stressors [elevated plus maze (EPM) and resident-intruder test]. Brain tissue was collected for analysis of central peptide levels in the hypothalamic paraventricular nucleus (PVN). Isolation produced autonomic changes [increased heart rate (HR) and decreased HR variability) during both acute stressors and increased anxiety behaviors in the EPM. Oxytocin injection prevented the autonomic consequences of the acute stressors in isolated prairie voles, but did not affect the behaviors tested under the present conditions. Oxytocin had no effect on the behavioral or autonomic responsiveness in paired prairie voles. Oxytocin injection may exert a beneficial effect on autonomic responses to stressors in isolated animals through increasing the number of oxytocin-containing neurons and decreasing the number of corticotropin-releasing hormone-containing neurons in the PVN. Oxytocinergic mechanisms may serve to compensate for autonomic responses associated with chronic isolation and exposure to both social and non-social acute stressors.     

A 10-day developmental voyage: converging evidence from three studies showing that self-esteem may be elevated and maintained without negative outcomes

Empirical evidence shows that educational experiences in the context of the outdoors lead to elevated self-esteem. Although elevated self-esteem is widely assumed to promote beneficial outcomes, recent evidence suggests that elevated self-esteem may also facilitate a variety of negative outcomes (i.e., increased prejudice, aggression, drug and alcohol abuse). The current research was conducted in order to examine whether one type of outdoor educational experience—a 10-day developmental voyage—could elevate adolescents’ self-esteem without also elevating negative outcomes. The data from three separate studies are reported. Study one revealed that adolescents who undertook the voyage manifested elevated self-esteem and decreased gender prejudice (i.e., less negative ratings of opposite sex outgroup members). Study two replicated these findings and further demonstrated that these effects were maintained 4–5 months following the voyage. In study three, in addition to self-esteem, risky attitudes (i.e., towards drug and alcohol use), physical aggression, verbal aggression, racial and gender bias were also examined. Adolescents again showed elevated self-esteem that was maintained 4–5 months following the voyage. There were no changes in risky attitudes, aggression, or racial and gender bias. Taken together these results indicate that taking part in a 10-day developmental voyage—can lead to an elevation in self-esteem, that is maintained over time and which does not facilitate a variety of negative outcomes.     

Biased attentional processing of positive stimuli in social anxiety disorder: an eye movement study

Despite the established relationship between social anxiety and attentional bias towards threat, a growing base of evidence suggests that social anxiety is additionally maintained by a deficit in the attentional processing of positive information. However, it remains unclear which component of attention is implicated in this deficit. Using eye movement-based measures and a novel attentional cuing methodology, the present study sought to investigate the presence of anxiety-linked bias in attentional engagement with, attentional disengagement from, and total fixation time to, socially relevant emotional stimuli in individuals diagnosed with social anxiety disorder, relative to non-socially anxious controls. Socially anxious individuals were found to exhibit faster attentional disengagement from positive stimuli, and reduced total fixation time to all emotional stimuli, relative to controls. Additionally for socially anxious individuals, lower total fixation times to positive stimuli were associated with higher levels of state anxiety. No differential pattern of engagement was evident between groups. We conclude that social anxiety is maintained in part by the aberrant processing of positive social stimuli.     

The role of disgust emotions in the observer response to facial disfigurement

Social intrusions by observers are commonly reported by those with disfiguring conditions. This study examined the role of disgust emotions in the observer response. A group of students (N = 48) completed quantitative questionnaires measuring extent of disfigurement, whilst viewing images of faces with varying disfigurements. Another group of students (N = 84) completed quantitative questionnaires measuring level of disgust elicited by the same images. Disgust sensitivity was measured using the Disgust Scale Revised. Observers reported greater levels of disgust (p < .01) with increasing severity of facial disfigurement. Individuals with a higher disgust sensitivity reported increased levels of disgust in response to faces of mild (p = .03), moderate (p = .02) and severe (p < .01) disfigurement compared to those with a lower disgust sensitivity. This provides an explanatory framework for the avoidance reactions of observers and may be important in understanding variability in adjustment following disfigurement.     

Book review

Raison et déraison d'État. Théoriciens et theories de la raison d'État aux XVIe et XVIIe siècles sous la direction de Yves Charles Zarka Paris, Presses Universitaires de France, 1994 pp. 436, 248 FF. ISBN 9–782130–461616.

Beverly C. Southgate: ’Covetous of Truth’: The Life and Work of Thomas White, 1593–1676 Dordrecht: Kluwer Academic Publishers, 1993. 189 pp. £60.00 ISBN 0–7923–1926–5

George Dicker: Descartes: An Analytical and Historical Introduction Oxford University Press, 1993 (248 pp.) £14.95 pbk. ISBN 0–19–507590–0

Theo Verbeek: Descartes and the Dutch: Early Reactions to Cartesian Philosophy, 1637–1650. Carbondale and Edwardsville, Southern Illinois University Press, 1992, x + 168 pp. $30.00 ISBN 0–8093–1617‐X

David Berman: George Berkeley: Idealism and the Man Oxford University Press, 1994. £27.50 ISBN 0–19–826746–0

Joseph Mali: The Rehabilitation of Myth: Vico's New Science Cambridge: Cambridge University Press, 1992. pp. xv + 275. £35.00 ISBN 0–521–41952–2

R. C. Solomon and K. W. Higgins (eds): The Age of German Idealism Routledge: London, 1993. Pp. 408. £55.00 (hbk) ISBN 0–415–05604–7

T. L. S. Sprigge: James and Bradley: American Truth and British Reality Chicago and La Salle, Illinois: Open Court, 1993 Pp. xiv + 630. $66.95 (hbk), $29.95 (pbk). ISBN 0–8126–9227–6 (pbk)

A. W. Moore: The Infinite Routledge, London and New York (1990). First published in paperback, 1991. xiv + 268 pp., £10.99 ISBN 0–415–07048–1     

Gist perception requires attention

Four experiments (240 subjects) explored gist perception without attention using the Mack and Rock (1998) cross task. Twelve scenes were flashed under conditions of inattention, divided, and full attention. Subjects described what they saw on critical trials in which a scene was flashed with the cross. In Experiments 3 and 4 subjects also chose the scene from a four scene array. In Experiment 4 the critical scenes were shown twice in the inattention condition. Overall, only 17% reported gist in the inattention condition, 65% did so with divided, and 82% did so with full attention. In Experiment 4 most subjects remained inattentionally blind to the scenes even though they were shown twice, conditions which fostered repetition priming, and we found a suggestion of negative priming. The results of all 4 experiments indicate that gist requires attention.