Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent

Mood disorders and chronic stress are frequently associated with gastrointestinal (GI) symptoms including diarrhoea or constipation. Locally produced serotonin [5-hydroxytryptamine (5-HT)] regulates GI motility and is a key factor in the pathophysiology of stress-associated GI disorders. We aimed to establish whether chronic stress can differentially affect faecal output and colon 5-HT concentration in two inbred mouse strains: BALB/c and C57BL/6 which differ in their ability to cope with stress. Adult male BALB/c and C57BL/6 mice were restrained for 2?h daily for 10 days. Defecation was monitored during each stress session. Twenty-four hours after the last session of stress, plasma corticosterone concentration was higher than control in both strains, indicative of a physiological effect of chronic stress; however, stress-induced diarrhoea was more persistent in C57BL/6 mice. Basal concentration of colon 5-HT was higher in C57BL/6 mice, and stress elicited an increase in colon 5-HT only in this strain. Finally, na?ve BALB/c mice had a higher sensitivity (incidence of diarrhoea) to 5-HT (0.33?mg/kg, i.p.) than C57BL/6 mice. Our results suggest that differential defecation responses to stress may be associated with colon 5-HT concentration, which may in turn reflect the individual sensitivity to 5-HT. In addition, C57BL/6 mice emerge as a relevant model for studying GI alterations induced by chronic stress.     

Resisting and Conforming to the ‘Lesbian Look’: The Importance of Appearance Norms for Lesbian and Bisexual Women

Appearance is one way in which lesbian and bisexual identities and affiliation to lesbian, gay, bisexual (LGB) subculture can be demonstrated. ‘Butch’ and ‘androgynous’ styles have been used by lesbian women to communicate a non‐heterosexual identity. However, some LGB appearance researchers have argued that there has been a mainstreaming and diversification of lesbian style in the last couple of decades, which has resulted in less distinction between lesbian and straight looks. This research draws on the Social Identity approach to explore contemporary style in lesbian and bisexual communities. Fifteen lesbian and bisexual women took part in semi‐structured interviews which were analysed using thematic analysis. Although some participants reported a diversification of lesbian style, most used the term ‘butch’ to describe lesbian style, and a ‘boyish’ look was viewed as the most common contemporary lesbian style. By contrast, most participants could not identify distinct bisexual appearance norms. The data provide evidence of conflicting desires (and expectations) to visibly project social identity by conforming to specific lesbian styles, and to be an authentic, unique individual by resisting these subcultural styles. Copyright © 2013 John Wiley & Sons, Ltd.     

Heidegger,Hermeneutics and History: Undermining Jeff Malpas’s Philosophy of Place

Most works about the philosophy of Martin Heidegger either disregard Heidegger’s attachment to National Socialism or assume the ‘minimalist’ view that his attachment was a brief political aberration of no consequence for his philosophy. This paper contends that the minimalist view is not only factually wrong but also that its assumption promotes methodological errors and poor philosophy. To assess this contention we examine two important texts from one of the more fertile fields in current philosophy: Jeff Malpas’s Heidegger’s Topology: Being, Place, World (2006) and Heidegger and the Thinking of Place (2012). Malpas claims that Heidegger’s rejection of National Socialism spurred, or was concomitant with, new directions in his philosophy. These claims are wrong. The paper concludes that any work about Heidegger’s philosophy must first acknowledge and understand his enduring attachment to National Socialism.     

Neuroscience,quantum indeterminism and the Cartesian soul

Quantum indeterminism is frequently invoked as a solution to the problem of how a disembodied soul might interact with the brain (as Descartes proposed), and is sometimes invoked in theories of libertarian free will even when they do not involve dualistic assumptions. Taking as example the Eccles–Beck model of interaction between self (or soul) and brain at the level of synaptic exocytosis, I here evaluate the plausibility of these approaches. I conclude that Heisenbergian uncertainty is too small to affect synaptic function, and that amplification by chaos or by other means does not provide a solution to this problem. Furthermore, even if Heisenbergian effects did modify brain functioning, the changes would be swamped by those due to thermal noise. Cells and neural circuits have powerful noise-resistance mechanisms, that are adequate protection against thermal noise and must therefore be more than sufficient to buffer against Heisenbergian effects. Other forms of quantum indeterminism must be considered, because these can be much greater than Heisenbergian uncertainty, but these have not so far been shown to play a role in the brain.     

Madhouse and the whole thing there

This article presents an autoethnography in the form of a short story of the experiences of a mental breakdown, and subsequent involuntary detainment, alongside the experiences of conducting PhD research outside the mainstream of the discipline of psychology. In response to criticisms of narrative approaches that they are methodologically solipsistic and present a socially atomised self, this narrative combines patient medical records with narrative recollections and reflections on the research process from a contemporary perspective. In doing so, the narrative explores and interrogates themes relevant to creative practice in psychological research, including the notion of authenticity, methodological issues of researching personal experience, the problem of subjectivity and, ultimately, the nature of madness and psychological distress, including its nonlinearity and otherness.     

Thai Norms for Name,Image, and Category Agreement,Object Familiarity,Visual Complexity,Manipulability, and Age of Acquisition for 480 Color Photographic Objects

Normative databases containing psycholinguistic variables are commonly used to aid stimulus selection for investigations into language and other cognitive processes. Norms exist for many languages, but not for Thai. The aim of the present research, therefore, was to obtain Thai normative data for the BOSS, a set of 480 high resolution color photographic images of real objects (Brodeur et al. in PLoS ONE 5(5), 2010.  https://doi.org/10.1371/journal.pone.0010773). Norms were provided by 584 Thai university students on eight dimensions: name agreement, object familiarity, visual complexity, category agreement, image agreement, two types of manipulability (graspability and mimeability), and age of acquisition. The results revealed comparatively similar levels of name agreement to Brodeur et al. especially when unfamiliar items were factored out. The pattern of intercorrelations among the Thai psycholinguistic norms was comparable to previous studies and our cross-linguistic correlations were robust for the same set of pictures in English and French. Conjointly, the findings extend the relevancy of the BOSS to Thailand, supporting this photographic resource for investigations of language and other cognitive processes in monolingual, multilingual, and brain-impaired populations.     

Psychological management and body image issues in facial transplantation

Facial transplantation, although controversial, is proposed as a major advance in facial reconstructive surgery, with the first partial transplant having taken place in France in November 2005. Although the psychological impact of facial transplantation will not be understood until several procedures have been carried out, this article examines the psychological issues likely to arise with particular reference to body image. A detailed framework for anticipation and management of psychological change is proposed. Pre-operative preparation must include thorough psychological preparation for the patient and their family. The immediate post-operative period is likely to be challenging, and a detailed management plan is proposed emphasising early return to function; subsequent psychological issues including altered body image, anxiety, shame, depression, communication and behavioural avoidance are discussed and a management strategy based on cognitive behavioural principles is proposed for the first post-operative year. Previous discussion frames psychological outcome in terms of complication and risk, tending to downplay the potential advantages of a successful procedure; the focus of this paper is on ensuring psychological adjustment as an inevitable consequence of change.     

Book reviews

John Christian Laursen (ed.). Religious Toleration: ‘The Variety of Rites’ from Cyrus to Defoe. New York, St Martin's Press, 1999. xx + 252 pp. $45.00. ISBN 0–312–22233–5.

Daniel Garber. Descartes Embodied: Reading Cartesian Philosophy through Cartesian Science Cambridge, Cambridge University Press, 2001, £40.00 hb; £14.95 pb. xii + 337 pp. ISBN 0–521–00337–7 pb. 0–521–80279–2 hb.

Olli Koistinen and John Biro (eds). Spinoza: Metaphysical Themes, Oxford, Oxford University Press, 2002. x + 255 pp. £40.00. ISBN 0–19–512815‐X.

Paul Abela. Kant's Empirical Realism. Oxford and New York, Clarendon Press, 2002. vii + 303 pp. £40.00. ISBN 0–19–924274–7.

Bruce L. Kinzer. England's Disgrace? J. S. Mill and the Irish Question. Toronto, Buffalo, and London, University of Toronto Press, 2001. 292 pp. $60. ISBN 0–8020–4862–5.

Maria Dimova‐Cookson. T. H. Green's Moral and Political Philosophy: A Phenomenological Perspective. Basingstoke, Palgrave, 2001. £40.00. xiii + 175 pp. ISBN 0–333–9144–7.

Stephen Mulhall. Inheritance &; Originality. Wittgenstein, Heidegger, Kierkegaard. Oxford, Clarendon Press, 2001. £40.00. xii + 448 pp. ISBN 0–19–924390–5.

Paul Gorner. Twentieth‐Century German Philosophy. Oxford, Oxford University Press, 2000. iii + 225 pp. £12.99. ISBN 0–19–289309–2.

Karen Green. Dummett: Philosophy of Language. Cambridge, Polity Press, 2001. xi + 236 pp. £55.00 (hb), £14.99 (pb). ISBN 0–7456–2294–1 (hb) 0–7456–2295‐X (pb).