首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   2275篇
  免费   98篇
  国内免费   1篇
  2374篇
  2022年   16篇
  2021年   18篇
  2020年   37篇
  2019年   35篇
  2018年   58篇
  2017年   63篇
  2016年   99篇
  2015年   55篇
  2014年   63篇
  2013年   225篇
  2012年   90篇
  2011年   114篇
  2010年   72篇
  2009年   58篇
  2008年   105篇
  2007年   78篇
  2006年   78篇
  2005年   96篇
  2004年   66篇
  2003年   57篇
  2002年   67篇
  2001年   33篇
  2000年   51篇
  1999年   43篇
  1998年   35篇
  1997年   29篇
  1996年   23篇
  1995年   28篇
  1994年   30篇
  1993年   20篇
  1992年   23篇
  1991年   20篇
  1990年   24篇
  1989年   25篇
  1988年   28篇
  1987年   21篇
  1986年   23篇
  1985年   24篇
  1984年   19篇
  1983年   23篇
  1982年   18篇
  1981年   21篇
  1980年   16篇
  1979年   24篇
  1977年   14篇
  1974年   14篇
  1973年   14篇
  1971年   13篇
  1970年   14篇
  1968年   18篇
排序方式: 共有2374条查询结果,搜索用时 0 毫秒
881.
Next generation sequencing (NGS) gene panels are increasingly used in medical genetics clinics for the evaluation of common inherited cancer syndromes, but the clinical efficacy of these tests, and the factors driving clinical providers to order them are unclear. We conducted a patterns-of-care study to compare patients evaluated with NGS gene panels with a reference group. We abstracted demographic, socioeconomic, and clinical information in a retrospective cohort of patients referred to a large medical genetics clinic for evaluation of inherited colorectal cancer and polyposis syndromes. Patients tested with NGS gene panels were more likely to be insured compared to the reference group (85.3 % vs. 69.2 %, p = 0.0068),less likely to have prior tumor tissue testing (29.4 % vs. 54.3 %, p = 0.0004), and less likely to have an abnormal tumor tissue test result (46.7 % vs. 74.5 %, p = 0.01). No significant differences were found between groups in age, gender, race, employment status, personal history of colorectal cancer, or proportion of patients fulfilling Lynch syndrome clinical criteria. Patients with NGS testing were less likely to have a pathogenic/likely pathogenic variant detected (13.7 % vs. 31.9 %, p = 0.002). Patients referred for NGS testing to evaluate inherited colorectal cancer/polyposis risk appear to undergo tumor tissue testing less frequently than non-NGS testing patients. Further studies are needed to assess the most effective and cost-effective approach to genomic diagnosis in this patient population.  相似文献   
882.
There are currently multiple paths through which genetic counselors can acquire advanced knowledge and skills. However, outside of continuing education opportunities, there are few formal training programs designed specifically for the advanced training of genetic counselors. In the genetic counseling profession, there is currently considerable debate about the paths that should be available to attain advanced skills, as well as the skills that might be needed for practice in the future. The Association of Genetic Counseling Program Directors (AGCPD) convened a national committee, the Committee on Advanced Training for Certified Genetic Counselors (CATCGC), to investigate varied paths to post-master’s training and career development. The committee began its work by developing three related grids that view career advancement from the viewpoints of the skills needed to advance (skills), ways to obtain these skills (paths), and existing genetic counselor positions that offer career change or advancement (positions). Here we describe previous work related to genetic counselor career advancement, the charge of the CATCGC, our preliminary work in developing a model through which to view genetic counselor advanced training and career advancement opportunities, and our next steps in further developing and disseminating the model.  相似文献   
883.
884.
885.
The freshman class of a midwestern medical school completed measures of masculinity and femininity, Type A behavior, and a variety of dependent variables concerning psychological well-being, adjustment, and interpersonal satisfaction. Appropriate statistical treatment of the data revealed strong and consistent masculinity effects on neuroticism, depression, self-esteem, confidence, hedonic capacity, locus of control, and relationship satisfaction. Femininity main effects varied in number as a function of the statistical method employed and involved a more diverse group of variables than is typically reported. Additive androgyny formulations of mental health were supported; balance androgyny formulations were not. No evidence for a Type A X Masculinity effect on adjustment was found. Discussion focuses on the correct interpretation of masculinity and femininity scales, comparability of analysis of variance (ANOVA) and multiple regression statistical analyses, and the viability of the concept of androgyny.  相似文献   
886.
887.
888.
889.
David A. Clark   《Behavior Therapy》2005,36(4):401-404
This commentary discusses a number of pertinent concerns that were raised in this special series on subtyping in obsessive-compulsive disorders (OCD). The central question addressed in the three articles in the series is whether a better subtype classification of OCD could be developed if it is based on type of faulty cognition as well as symptom presentation. It is concluded that a more cognitive approach to OCD subtyping may not address many of the problems inherent in subtype research, nor will the development of special manualized treatment protocols for OCD subtypes necessarily yield significant improvements in treatment effectiveness. An alternative to OCD subtyping based on a categorical perspective is some form of profiling that recognizes the dimensional nature of OCD symptom and cognition variables.  相似文献   
890.
Everall RD  Bostik KE  Paulson BL 《Adolescence》2005,40(160):693-708
Adolescence is a developmental transition period during which there are profound transformations in emotional, cognitive, and behavioral systems. Despite being a time of rapid development and increasing rates of suicidality, limited research has examined possible interrelationships. Through the use of a case study, this paper illustrates the role of developmental factors in a teenage girl's experience becoming and overcoming being suicidal. The processes of cognitive development, identity formation, and autonomy-seeking are discussed within the context of her story.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号