Psychological Factors Associated with Emotional Responses to Receiving Genetic Risk Information

This study identified levels of distress, and predictors of levels of distress, in women undergoing assessment for genetic risk of breast/ovarian cancer based on their family history. It comprised a cohort study following 154 women who completed questionnaires at entry into a cancer genetic assessment programme and following risk provision. Independent significant associates of anxiety following risk provision were age, neuroticism, feeling hopeless about developing cancer, a perceived lack of control over developing cancer, lack of a social confidant, and a coping response involving acceptance/resignation. Depression was associated with age, neuroticism, feeling hopeless about developing cancer, lack of social confidant, and a coping response involving acceptance/resignation. To avoid high levels of psychological morbidity in future cohorts undergoing cancer genetic risk assessment, information should be given that emphasises that some degree of control over health outcomes through behaviour change or increased surveillance is possible.     

Should I trust you? Autistic traits predict reduced appearance‐based trust decisions

Facial impressions of trustworthiness guide social decisions in the general population, as shown by financial lending in economic Trust Games. As an exception, autistic boys fail to use facial impressions to guide trust decisions, despite forming typical facial trustworthiness impressions (Autism, 19, 2015a, 1002). Here, we tested whether this dissociation between forming and using facial impressions of trustworthiness extends to neurotypical men with high levels of autistic traits. Forty‐six Caucasian men completed a multi‐turn Trust Game, a facial trustworthiness impressions task, the Autism‐Spectrum Quotient, and two Theory of Mind tasks. As hypothesized, participants’ levels of autistic traits had no observed effect on the impressions formed, but negatively predicted the use of those impressions in trust decisions. Thus, the dissociation between forming and using facial impressions of trustworthiness extends to the broader autism phenotype. More broadly, our results identify autistic traits as an important source of individual variation in the use of facial impressions to guide behaviour. Interestingly, failure to use these impressions could potentially represent rational behaviour, given their limited validity.     

Longitudinal associations between hostility in adolescents' family relationships and friendships and hostility in their romantic relationships.

This study examined longitudinal predictors of hostility in adolescents' romantic relationships. The sample included 110 adolescents and their parents from 72 families. Observational measures of parents' marital hostility and parent-child hostility and self-reports of hostility in close friendships were collected when adolescents ranged from 14 to 16 years old. Three years later, when they were 17 to 19 years old, adolescents reported on the hostility in their romantic relationships. Results indicated that hostility in parents' marital relationships and in adolescents' friendships accounted for independent variance in hostility in adolescents' later romantic relationships. Results highlight the importance of both family relationships and friendships for predicting hostility in adolescents' romantic relationships over time.     

Genetic factors in neuromuscular pain

Recent evidence suggests that fibromyalgia, a chronic widespread pain condition and related syndromes (chronic fatigue syndrome, irritable bowel syndrome, etc.) may share heritable pathophysiologic features. We review the recent literature on genetic and familial factors found to participate in the pathogenesis of these syndromes, specifically fibromyalgia, including evidence suggesting that serotonin- and dopamine-related genes may play a role in the pathogenesis of these illnesses. The importance of environmental factors triggering these conditions in predisposed individuals is also discussed.     

The impact of mothers' trait anxiety on their expectations of approach‐avoidance behaviour in anxious and non‐anxious children

This study investigated estimates of approach and avoidance behaviour in clinically anxious and non‐anxious children, and whether mothers' expectations of their children's avoidance differed as a function of high trait anxiety (HTA) versus low trait anxiety (LTA). Participants were 62 clinically anxious and 60 non‐anxious children aged 7–12 years and their mothers. Estimates of avoidance were obtained using an analogue task in which children and mothers were given threat and pleasant information about two novel animals and were asked to estimate children's avoidance of the threat animal's habitat when the threat animal was present (threat condition) and absent (safe condition) from the habitat and when its presence was uncertain (ambiguous condition). Contrary to expectation, anxious children did not differ from controls in estimates of avoidance in any condition. However, relative to HTA mothers of anxious children and LTA mothers of non‐anxious children, HTA mothers estimated greater approach behaviour by their non‐anxious children in the threat condition. Findings suggest that mothers' expectations of children's approach‐avoidance behaviour is influenced by both maternal and child factors.     

Dreading the boards: stress response to a competitive audition characterized by social-evaluative threat

The capacity of psychosocial stressors to provoke the hypothalamic–pituitary–adrenal axis has been demonstrated to vary depending upon a number of psychological factors. Laboratory stressors characterized by social-evaluative threat are proposed to be the most efficacious in the elicitation of a cortisol stress response. Salivary cortisol, cardiovascular, and subjective responses of 16 healthy adults facing a naturalistic stressor characterized by social-evaluative threat (competitive performance auditions) were examined. Audition exposure was sufficient to provoke significant cortisol, arterial blood pressure (systolic and diastolic), and subjective stress responses. Cortisol response reactivity (area under the curve with respect to increase [AUCi]) also correlated with participants' subjective rating of social-evaluative threat. The competitive performance audition context is therefore considered a promising context in which to further explore cortisol responsivity to social-evaluative threat.     

The State of the Question in the Study of Plato: Twenty Year Update

This article updates “The State of the Question in the Study of Plato” (Southern Journal of Philosophy , 1996 ) based on research covering the years from 1995–2015. Its three major parts examine: (1) how the mid‐twentieth‐century consensus has fared, (2) whether the new trends identified in that article have continued, and (3) identify trends either new or missed in the original article. On the whole, it shows the continuing decline of dogmatic and nondramatic Plato interpretation and the expansion and ramification of the more literary, dramatic, and nondogmatic “new Platonism.” What was a growing insurgency twenty years ago can now be described as a, if not the , dominant approach.     

11Beta-hydroxysteroid dehydrogenase type 1 activity in medial vestibular nucleus and cerebellum after unilateral vestibular deafferentation in the rat

In the early stages of vestibular compensation (VC) (the behavioural recovery that follows unilateral vestibular deafferentation), neurons in the medial vestibular nucleus (MVN) on the lesioned side develop a sustained up-regulation of their intrinsic excitability. This plasticity is dependent on the activation of glucocorticoid receptors, which presumably occurs during the acute stress response that accompanies the vestibular deafferentation symptoms. Recent studies have established that the access of glucocorticoids to their intracellular receptors in brain is potently modulated by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which catalyses the generation of active glucocorticoids from their inert 11-keto forms. In this study, we investigated the presence of 11beta-HSD1 bioactivity, and possible changes in activity in the early stage after vestibular deafferentation, in the cerebellar nodulus and uvula, the flocculus/paraflocculus (F/PF) complex and the MVN of the rat. 11beta-HSD1 activity was found in each of these brain areas, with especially high levels of activity in the F/PF complex. No differences were found in the level of 11beta-HSD1 activity in these brain areas between control rats, sham-operated rats and rats that underwent VC for 4 h after unilateral vestibular deafferentation. These findings demonstrate 11beta-HSD1 bioactivity in the MVN and vestibulocerebellum, but exclude the possibility that changes in 11beta-HSD1 activity occur in the early period after deafferentation, over the time when changes in MVN neuronal properties take place.