Developmental outcomes after early prefrontal cortex damage

The neuropsychological bases of cognitive, social, and moral development are minimally understood, with a seemingly wide chasm between developmental theories and brain maturation models. As one approach to bridging ideas in these areas, we review 10 cases of early prefrontal cortex damage from the clinical literature, highlighting overall clinical profiles and real life developmental outcomes. Based on these cases, there is preliminary evidence to support distinctive developmental differences after: (1) dorsolateral, (2) mesial, and (3) orbital-polar prefrontal lesions, for more profound impairments after bilateral damage, and possibly for recovery differences after very early vs. later childhood lesion onset. Further case and group studies are needed to confirm reliable effects of specific lesion locations, the influence of age of lesion onset, and related experiential and treatment variables in determining adult outcomes. Rather than a single underlying deficit associated with early prefrontal cortex damage, we interpret the findings to suggest that it is the altered integration and interplay of cognitive, emotional, self-regulatory, and executive/metacognitive deficits that contribute to diverse developmental frontal lobe syndromes. The findings support the fundamental importance of prefrontal cortex maturation in protracted cognitive, social-emotional, and moral development.     

Variations of tool and task characteristics reveal that tool-use postures are anticipated

The authors examined anticipation in tool use, focusing on tool length and tool-use posture. Adults (9 women and 9 men in each experiment) held a rod (length 0.4-0.8 m), with the tip upward; walked toward a cube; chose a place to stop; and displaced the cube with the rod's tip. In 2 experiments, rod length, mass, and mass distribution, and the size of the cube were manipulated. Chosen distance depended on rod length and cube size. Because effects of cube size on distance resulted only from postural changes related to required control, distance anticipated displacement posture. A postural synergy comprising legs and trunk provided a stable platform for the displacement. An arm synergy was less extended for small cubes, longer rods, and handle-weighted rods. Selected distance anticipated those postures.     

Rigidity in children's drawings and its relation with representational change

Four studies tested the application of to the drawing domain. In particular, we tested her claim that young children are inhibited in their attempts at changing their graphic representations (representational change) due to being constrained by the order in which the elements of the representation are drawn (procedural rigidity). The first study required 60 children (4- to 6-year-olds and an older comparison group of 8-year-olds) to make three drawings of a familiar and novel topic. From these drawings each child was measured for procedural rigidity. In a further drawing the child was asked to modify their usual representation of each topic. Regression analyses revealed procedural rigidity levels were not predictive of manipulation performance. A second study, testing 75 4- to 6-year-olds and a third study, testing 30 3- to 4-year-olds, revealed that when young children were specifically asked to manipulate rigid sub-procedures on a familiar topic they were indeed able to do so. Finally, a fourth study (testing 40 5-year-olds and 40 8-year-olds) removed the notational trace in drawing (a possible aid for procedural interruption) but this still produced no evidence of a relation between procedural rigidity and representational change. We suggest how the concept of procedural rigidity might be re-interpreted for the drawing domain so that the RR model can remain as a domain-general theory of cognitive development. We also suggest the development of information processing may be crucial for flexibility in drawing.     

The information for catching fly balls: judging and intercepting virtual balls in a CAVE

Visually guided action implies the existence of information as well as a control law relating that information to movement. For ball catching, the Chapman Strategy--keeping constant the rate of change of the tangent of the elevation angle (d(tan(alpha))/dt)--leads a catcher to the right location at the right time to intercept a fly ball. Previous studies showed the ability to detect the information and the consistency of running patterns with the use of the strategy. However, only direct manipulation of information can show its use. Participants were asked to intercept virtual balls in a Cave Automated Virtual Environment (CAVE) or to judge whether balls would pass behind or in front of them. Catchers in the CAVE successfully intercepted virtual balls with their forehead. Furthermore, the timing of judgments was related to the patterns of changing d(tan(alpha))/dt. The advantages and disadvantages of a CAVE as a tool for studying interceptive action are discussed.     

Geometrics and dynamics of a rod determine how it is used for reaching

Displacing an object with a hand-held rod provided a simple paradigm for studying tool use. The authors asked how reaching was affected by manipulations of rod properties. Adults held a rod (length =.10 to 1.5 m), with its tip in the air; walked toward an object on a table; chose a place to stop; and displaced the object with the rod's tip. In 3 experiments (Ns = 9, 22, and 17 participants), the authors manipulated rod length, mass, and mass distribution to determine whether and how geometric and dynamic properties affected the chosen distance and the posture. Both the chosen stopping distance and the postures were well accommodated to rod characteristics. Postural adaptations took place only in the arm, which was organized as a synergy. Predictably, rod length explained most of the variance, but small and reliable differences in both distance and posture depended on mass and mass distribution. The chosen distance anticipated not only rod length but also the upcoming posture needed to control the rod.     

Pragmatic Assessment and Therapy for Persons with Brain Damage: What Have Clinicians Gleaned in Two Decades?

Pragmatic competence comprises a number of interrelated skills which manifest in real-time in a range of adaptive behaviors and which are driven by underlying cognitive processes that appear to be variably compromised in brain damage. Differential neurological profiles reflect different pragmatic outcomes. The essence of pragmatic assessment and therapy for clinicians is therefore to capture accurately, measure, and, where possible, enhance the ability of the individual to adapt to a changing communicative environment. Assessment measures differ along a number of dimensions. A distinction is drawn between testing and assessment and the argument proposed that for clinical purposes, it is helpful to keep the notions of functional and pragmatic distinct.     

Understanding of Genetic Inheritance among Xhosa-Speaking Caretakers of Children with Hemophilia

Hemophilia A and B are X-linked recessive inherited bleeding disorders that have a profound impact on the family of affected individuals. Education is vital to enable women to appreciate the implications of being a carrier and the implications for a prospective child. Prior research has shown that cultural, socio-economic and linguistic issues in South Africa are major barriers to communication for first-language Xhosa-speakers. This exploratory study aimed to investigate the basic knowledge of genetic inheritance among this cultural group in order to promote culturally-sensitive, effective genetic counseling. Ten in-depth interviews were conducted with Xhosa-speaking mothers or caregivers of boys with hemophilia. Results suggest that the participants had a very limited understanding of the clinical management, genetic consequences and cause of hemophilia. While treatment and care by health care service providers was fully accepted, several participants believed that traditional methods would provide them with more satisfactory explanations. These findings suggest that there is a critical need for socio-culturally tailored, language-specific education for families with hemophilia.     

The end of analysis for the analyst (Translated by Ann Kutek)

This paper is an account of an analyst's personal exploration to make conceptual sense of the delicate closing stages of an analysis. Jung's theory of complexes provides a model of the functioning of the analytic relationship as an integral whole which itself is the locus of the process that brings an analysis to completion. Clinical vignettes are used to illustrate this.     

EARLY RESPONSE DISTRIBUTION AND OUTCOMES OF RESPONSE-RESTRICTION ANALYSES

We examined whether the results of a response‐restriction analysis (RRA) could be predicted on the basis of response distribution in early sessions, when these sessions indicated interaction with multiple items. Four preschool‐aged children participated. For 3 of the 4 participants, the results from sessions conducted prior to restriction of the first item corresponded closely with results of the full RRA.     

Repetition blindness reveals differences between the representations of manipulable and nonmanipulable objects

We used repetition blindness to investigate the nature of the representations underlying identification of manipulable objects. Observers named objects presented in rapid serial visual presentation streams containing either manipulable or nonmanipulable objects. In half the streams, 1 object was repeated. Overall accuracy was lower when streams contained 2 different manipulable objects than when they contained only nonmanipulable objects or a single manipulable object. In addition, nonmanipulable objects induced repetition blindness, whereas manipulable objects were associated with a repetition advantage. These findings suggest that motor information plays a direct role in object identification. Manipulable objects are vulnerable to interference from other objects associated with conflicting motor programs, but they show better individuation of repeated objects associated with the same action. (PsycINFO Database Record (c) 2012 APA, all rights reserved).