Assessment of Psychosocial Outcomes in Genetic Counseling Research: An Overview of Available Measurement Scales

The aim of the present paper was to describe and evaluate many of the measurement scales currently used in genetic counseling outcomes research. A team of three researchers reviewed the available literature and selected a variety of validated instruments suitable for measurement of genetic counseling outcomes. There are numerous scales to assess each of the following outcomes among counselees: satisfaction with genetic counseling; knowledge; decision-making; psychological adjustment; coping; perceived personal control; perceptions of disease risk; and family communication about genetic risk. However, the strengths and limitations inherent to each instrument warrant careful consideration prior to implementation. In the genetic counseling context, scale selection should be undertaken with thought directed towards the characteristics of the research sample (e.g. levels of literacy, culture, medical condition), the practicalities of the research setting (e.g. available funding and resources, time restrictions, researcher expertise), the purpose of the research (i.e. the specific aspect of the genetic counseling experience to be studied), and the science underlying the scale (e.g. theoretical framework, psychometric properties).     

Anticipating seizure: pre-reflective experience at the center of neuro-phenomenology

The purpose of this paper is to show through the concrete example of epileptic seizure anticipation how neuro-dynamic analysis (using new mathematical tools to detect the dynamic structure of the neuro-electric activity of the brain) and "pheno-dynamic" analysis (using new interview techniques to detect the pre-reflective dynamic micro-structure of the corresponding subjective experience) may guide and determine each other. We will show that this dynamic approach to epileptic seizure makes it possible to consolidate the foundations of a cognitive non pharmacological therapy of epilepsy. We will also show through this example how the neuro-phenomenological co-determination could shed new light on the difficult problem of the "gap" which separates subjective experience from neurophysiological activity.     

Expression of the emotions in the drawing of a man by the child from 5 to 11 years of age]

This study examines the development of children's ability to express emotions in their human figure drawing. Sixty children of 5, 8, and 11 years were asked to draw "a man," and then a "sad", "happy," "angry" and "surprised" man. Expressivity of the drawings was assessed by means of two procedures: a limited choice and a free labelling procedure. Emotionally expressive drawings were then evaluated in terms of the number and the type of graphic cues that were used to express emotion. It was found that children are able to depict happiness and sadness at 8, anger and surprise at 11. With age, children use increasingly numerous and complex graphic cues for each emotion (i.e., facial expression, body position, and contextual cues). Graphic cues for facial expression (e.g., concave mouth, curved eyebrows, wide opened eyes) share strong similarities with specific "action units" described by Ekman and Friesen (1978) in their Facial Action Coding System. Children's ability to depict emotion in their human figure drawing is discussed in relation to perceptual, conceptual, and graphic abilities.     

Driving and riding avoidance following motor vehicle crashes in a non-clinical sample: psychometric properties of a new measure

Three studies were conducted to assess the reliability and validity of a measure that we developed using a non-clinical sample of university undergraduates, the Driving and Riding Avoidance Scale (DRAS). Study 1 indicated that the scale was internally consistent (α=0.92) and that a four-factor model (general avoidance, avoidance of traffic and busy roads, avoidance of weather or darkness, and riding avoidance) provided the best fit to the data in a sample of 386 crash survivors. This study also revealed that survivors who received medical treatment for their crash-related injuries reported significantly greater avoidance than people who were uninjured or injured and not medically treated. Study 2 revealed that the DRAS possessed acceptable test-retest reliability (r=0.83) over a 4-week interval in a sample of 67 crash survivors. Using a sample of 118 survivors, study 3 examined the instrument’s convergent and divergent validity through correlations with the Accident Fear Questionnaire (AFQ), the Mobility Inventory (MI), the Fear Survey Schedule-II (FSS-II), and the Fear Questionnaire (FQ). The strongest relationships were observed between the DRAS and the AFQ and with a driving subscale created from the MI items. The DRAS exhibited significantly weaker relationships with the FQ subscales that assessed other kinds of phobic avoidance.     

Analysis of response allocation in individuals with multiple forms of stereotyped behavior

Three experiments were conducted to evaluate response allocation of stereotypy during free-operant and restricted-operant conditions. Five children with autism or related developmental disabilities participated in at least one and up to three of the experiments. In Experiment 1, the stereotypic response that emerged as most probable during a free-operant phase was restricted, and response allocation was again evaluated. The results for 3 participants showed that restricting the high-probability response was correlated with covarying reductions in a nontargeted stereotypy. In Experiment 2, the effect of environmental enrichment on response allocation was evaluated. One participant reallocated behavior to appropriate object manipulation, 1 participant showed no change in behavior, and a 3rd participant reallocated behavior to object manipulation only when the putative stimulus products of the object manipulation matched those of stereotypy. In Experiment 3, additional interventions were implemented to promote response reallocation. Results showed that both response restriction and reinforcement for object manipulation decreased stereotypy and increased object manipulation. Collectively, the results of these experiments point to a need for complex evaluations of interventions for stereotypy.     

Warm and homely or cold and beautiful? Sex differences in trading off traits in mate selection

Prior research and theory suggest that people use three main sets of criteria in mate selection: warmth/trustworthiness, attractiveness/vitality, and status/resources. In two studies, men and women made mating choices between pairs of hypothetical potential partners and were forced to make trade-offs among these three criteria (e.g., warm and homely vs. cold and attractive). As predicted, women (relative to men) placed greater importance on warmth/trustworthiness and status/resources in a potential mate but less importance on attractiveness/vitality. In addition, as expected (a) ratings of ideal standards partly mediated the link between sex and mate choices, (b) ideal standards declined in importance from long-term to short-term relationships, with the exception of attractiveness/vitality, and unexpectedly, (c) sex differences were higher for long-term (compared to short-term) mate choice. Explanations and implications are discussed.     

Effects of model-based and memory-based processing on speed and accuracy of grammar string generation

Learners are able to use 2 different types of knowledge to perform a skill. One type is a conscious mental model, and the other is based on memories of instances. The authors conducted 3 experiments that manipulated training conditions designed to affect the availability of 1 or both types of knowledge about an artificial grammar. Participants were tested for both speed and accuracy of their ability to generate letter sequences. Results indicate that model-based training leads to slow accurate responding. Memory-based training leads to fast, less accurate responding and highest achievement when perfect accuracy was not required. Evidence supports participants' preference for using the memory-based mode when exposed to both types of training. Finally, the accuracy contributed by model-based training declined over a retention interval.     

Cerebellar norepinephrine modulates learning of delay classical eyeblink conditioning: evidence for post-synaptic signaling via PKA

The neurotransmitter norepinephrine (NE) has been shown to modulate cerebellar-dependent learning and memory. Lesions of the nucleus locus coeruleus or systemic blockade of noradrenergic receptors has been shown to delay the acquisition of several cerebellar-dependent learning tasks. To date, no studies have shown a direct involvement of cerebellar noradrenergic activity nor localized the post-synaptic response to cerebellar beta-noradrenergic receptor signaling. Using ipsilateral, localized infusions into cerebellar lobule HVI and interpositus (IP), we have established that blocking beta-noradrenergic receptors with propranolol significantly impairs acquisition of conditioned responses. Furthermore, interrupting activation of cAMP-dependent PKA in the cerebellum using Rp-cAMPS completely prevents acquisition. However, neither blocking beta-adrenergic receptors nor blocking PKA activation significantly interferes with performance of established conditioned responses when administered after the learned response is formed.     

Lateral interception I: operative optical variables, attunement, and calibration

J. J. Gibson (1966, 1979) suggested that improvement in perception and action can be attributed in part to changes in which variable is attended to. Such reattunement has been demonstrated with observers making judgments in response to simulations. The present study sought attunement changes in the perception of real events and in visually guided action. In 3 experiments, adults judged the passing distance of or attempted to catch balls. Discrete measures and the predictions of a modified required velocity model (e.g., R. J. Bootsma, V. Fayt, F. T. J. M. Zaal, & M. Laurent, 1997) were used to reveal which variables were exploited. Participants differed from each other and, to some extent, changed in the optical variables used, in catching as well as judging. Nevertheless, the changes were much smaller than in previous simulation-judgment studies; calibration was also found to underlie the improvements in performance.