Neurobiological and endocrine correlates of individual differences in spatial learning ability

The polysialylated neural cell adhesion molecule (PSA-NCAM) has been implicated in activity-dependent synaptic remodeling and memory formation. Here, we questioned whether training-induced modulation of PSA-NCAM expression might be related to individual differences in spatial learning abilities. At 12 h posttraining, immunohistochemical analyses revealed a learning-induced up-regulation of PSA-NCAM in the hippocampal dentate gyrus that was related to the spatial learning abilities displayed by rats during training. Specifically, a positive correlation was found between latency to find the platform and subsequent activated PSA levels, indicating that greater induction of polysialylation was observed in rats with the slower acquisition curve. At posttraining times when no learning-associated activation of PSA was observed, no such correlation was found. Further experiments revealed that performance in the massed water maze training is related to a pattern of spatial learning and memory abilities, and to learning-related glucocorticoid responsiveness. Taken together, our findings suggest that the learning-related neural circuits of fast learners are better suited to solving the water maze task than those of slow learners, the latter relying more on structural reorganization to form memory, rather than the relatively economic mechanism of altering synaptic efficacy that is likely used by the former.     

Individual Quality of Life Among at Risk Indigenous Youth in Australia

This paper reports the findings from a pilot study in which the Schedule for Individual Quality of Life (SEIQoL-DW) was used to determine how 15 at-risk Indigenous Australian male youths aged between 14 and 19 conceptualised their quality of life. The youths, who were referred with problems associated with drug and alcohol misuse and criminal activity, were attending a diversionary program run by an Indigenous organisation in the Northern Territory, Australia. Quality of life was measured before and at the end of the nine-day programme in order to evaluate outcomes. Program staff found the SEIQoL-DW to be particularly useful in identifying culturally specific quality of life domains, allowing interventions to focus on improving the life areas that were of particular value to individuals as well as recognizing any deficits in their understanding the options available to them. While a control group was not used, mean SEIQoL-DW scores increased significantly over the course of the program.     

The structure of the Beck Hopelessness Scale: A confirmatory factor analysis in UK students

The aim of this paper was to confirm the factor structure of the 20-item Beck Hopelessness Scale in a non-clinical population. Previous research has highlighted a lack of clarity in its construct validity with regards to this population.Based on previous factor analytic findings from both clinical and non-clinical studies, 13 separate confirmatory factor models were specified and estimated using LISREL 8.72 to test the one, two and three-factor models.Psychology and medical students at Queen’s University, Belfast (n = 581) completed both the BHS and the Beck Depression Inventory (BDI).All models showed reasonable fit, but only one, a four-item single-factor model demonstrated a non-significant chi-squared statistic. These four items can be used to derive a Short-Form BHS (SBHS) in which increasing scores (0-4) corresponded with increasing scores in the BDI. The four items were also drawn from all three of Beck’s proposed triad, and included both positively and negatively scored items.This study in a UK undergraduate non-clinical population suggests that the BHS best measures a one-factor model of hopelessness. It appears that a shorter four-item scale can also measure this one-factor model.     

The Dr. John Hall story: a case study in putative “Haunted People Syndrome”

ABSTRACT

Research suggests a “Haunted People Syndrome (HP-S)” defined by recurrent and systematic perceptions of anomalous subjective and objective anomalies. Such signs or symptoms are traditionally attributed to “spirits and the supernatural,” but these themes are hypothesised to morph to “surveillance and stalking” in reports of “group-(or gang) stalking,” We tested this premise with a quali-quantitative exercise that mapped group-stalking experiences from a published first-hand account to a Rasch measure of haunt-type anomalies. This comparison found significant agreement in the specific “signs or symptoms” of both phenomena. Meta-patterns likewise showed clear conceptual similarities between the phenomenology of haunts and group-stalking. Findings are consistent with the idea that both anomalous episodes involve the same, or similar, attentional or perceptual processes and thereby support the viability of the HP-S construct.