Knowledge of and Interest in Genetic Results Among Parkinson Disease Patients and Caregivers

The purpose of the study is to investigate Parkinson disease (PD) patients’ and caregivers’ knowledge of and interest in genetic testing. Gaucher disease (GD) results from recessive mutations in glucocerebrosidase (GBA). Both heterozygote GBA carriers and GD patients are at greater risk for PD. Studies regarding knowledge of and interest in genetic testing have been limited and have not offered genetic results to participants. In this study, 353 PD patients and 180 caregivers were recruited to a PD genetic study. The association between GD, GBA mutations and PD was described to participants who reported their familiarity with genetic terms, answered questions on genetic concepts, and indicated their interest in knowing if they may have GD (two GBA mutations) and other genetic information that could impact their health. Ninety-three-percent of participants were interested in receiving GBA results; however, only 51.6 % of PD participants and 55.6 % of caregivers knew that “scientists have identified genes associated with a higher risk of developing PD.” PD patients may benefit from education and genetic counseling on the implications of genetic testing.     

Use of Genetic Tests among Neurologists and Psychiatrists: Knowledge,Attitudes, Behaviors,and Needs for Training

This study explores neurologists’ and psychiatrists’ knowledge, attitudes, and practices concerning genetic tests. Psychiatrists (n?=?5,316) and neurologists (n?=?2,167) on the American Medical Association master list who had agreed to receive surveys were sent an email link to a survey about their attitudes and practices regarding genetic testing; 372 psychiatrists and 163 neurologists responded. A higher proportion of neurologists (74 %) than psychiatrists (14 %) who responded to the survey had ordered genetic testing in the past 6 months. Overall, most respondents thought that genetic tests should be performed more frequently, but almost half believed genetic tests could harm patients psychologically and considered legal protections inadequate. Almost half of neurologists (49 %) and over 75 % of psychiatrists did not have a genetics professional to whom to refer patients; those who had ordered genetic tests were more likely than those who did not do so to have access to a genetic counselor. Of respondents, 10 % had received patient requests not to document genetic information and 15 % had received inquiries about direct-to-consumer genetic testing. Neurologists reported themselves to be relatively more experienced and knowledgeable about genetics than psychiatrists. These data, the first to examine several important issues concerning knowledge, attitudes and behaviors of neurologists and psychiatrists regarding genetic tests, have important implications for future practice, research, and education.     

Abnormal diurnal pattern of cortisol secretion in patients after aneurysmal subarachnoid hemorrhage

Substantial evidence suggests that impairment of the hypothalamus?pituitary system can occur following an aneurysmal subarachnoid hemorrhage (aSAH). Given that the diurnal cortisol rhythm is primarily controlled by the hypothalamus?pituitary system, this study examined whether changes in diurnal cortisol rhythm occurred after aSAH. Cortisol concentrations were measured in the saliva samples collected from patients after aSAH and other types of cerebral hemorrhage (non-aSAH) in the post-awakening period and at night (21:00?h), and the cortisol awakening response (CAR) and diurnal cortisol decline were determined. The area under the cortisol curve from immediately after to 45?min after awakening (CARauc) in the aSAH patient group was comparable to that in the non-aSAH or healthy control groups. However, an obvious cortisol peak was not found after the awakening period, and the morning/nighttime cortisol ratio in the aSAH patient group was significantly lower than that in other examined groups due to higher nighttime cortisol concentrations. In aSAH patients, the CARauc and nighttime cortisol concentrations were negatively correlated with the Fisher CT grade. These results indicate that the diurnal cortisol rhythm is not regulated normally after aSAH, and cortisol secretory activity decreases as the volume of subarachnoid bleeding increases. Our findings will be helpful to understand altered hypothalamus?pituitary?adrenal axis function after aSAH.     

Development and validation of the Internalized Racial Oppression Scale for Black individuals

This article describes the development and validation of the Internalized Racial Oppression Scale (IROS) for Black individuals in 2 studies using a total sample of 468 Black college students. The IROS is intended to measure the degree to which racial oppression is internalized and replicated by Black individuals in the United States. An exploratory factor analysis suggested a five-factor solution: Belief in the Biased Representation of History (BRH), Devaluation of the African Worldview and Motifs (DAW), Alteration of Physical Appearance (APA), Internalization of Negative Stereotypes (INS), and Hair Change (HC). Confirmatory factory analysis supported an adequate model fit of a four-factor model: BRH, APA, INS, and HC. All factors of the IROS were positively correlated with the Pre-Encounter subscale of the Racial Identity Attitude Scale (RIAS-B; J. E. Helms & T. A. Parham, 1996), and 4 of the factors were negatively correlated with the Immersion/Emersion subscale of the RIAS-B. Four factors of the IROS were negatively correlated with all subscales and total scores of the African Self-Consciousness Scale (J. A. Baldwin & Y. R. Bell, 1985). These results provide some support of the validity of the IROS.     

The impact of ignoring multiple membership data structures in multilevel models

This study compared the use of the conventional multilevel model (MM) with that of the multiple membership multilevel model (MMMM) for handling multiple membership data structures. Multiple membership data structures are commonly encountered in longitudinal educational data sets in which, for example, mobile students are members of more than one higher-level unit (e.g., school). While the conventional MM requires the user either to delete mobile students' data or to ignore prior schools attended, MMMM permits inclusion of mobile students' data and models the effect of all schools attended on student outcomes. The simulation study identified underestimation of the school-level predictor coefficient, as well as underestimation of the level-two variance component with corresponding overestimation of the level-one variance when multiple membership data structures were ignored. Results are discussed along with limitations and ideas for future MMMM methodological research as well as implications for applied researchers.     

A Longitudinal Examination of Serious Adolescent Offenders’ Perceptions of Chances for Success and Engagement in Behaviors Accomplishing Goals

We examined antisocial adolescents’ perceptions of the importance of and their ability to accomplish positive life outcomes (e.g., employment) and avoid negative ones (e.g., arrests) during their transition from adolescence to young adulthood. Participants were 1,354 adolescents from the Pathways to Desistance project, a multisite longitudinal study of seriously antisocial adolescents. Participants’ perceptions of the importance and likelihood of accomplishing positive adult goals at one age uniquely predicted how often they engaged in behaviors that were consistent with these goals the following year. Our findings suggest that among serious adolescent offenders aspirations to achieve positive goals are related to engaging in behaviors that bring adolescents’ current selves more in line with their aspired-to future selves. We discuss the implications of these findings for prevention and intervention efforts.