Near-death experiences and the measurement of blood gases

Although cerebral anoxia is not thought to be responsible for triggering near-death experiences (NDEs), the issue is not so clear in the case of hypercapnia. Detection of normal blood gases in Michael Sabom's (1982) case study seems to be the major reply to suggestions that hypercapnia may have a causal role in NDEs. We argue, however, that routine arterial measures of blood gases are not a reliable indicator of cerebral levels.     

Agricultural policy and strategic investment in information technology

In this article the perspective shifts to the “upstream” end of the agricultural knowledge and information system (AKIS). Because knowledge policy and strategic decision-making are not the prerogative of the public sector, organizations such as cooperative unions and multinational companies are included. After considering the influence of the changing environment on the nature of the AKIS, the role of knowledge management and policy in the emerging knowledge and information market is examined. Special attention is given to public and private R&D. The article then looks where information technology (IT) fits in and what considerations determine strategic investment in IT projects and sustained services. Some of the European experiences with this strategic investment are evaluated.     

Behavioral knowledge among direct care staff in an inpatient psychiatric setting

Despite demonstrations of the utility and cost effectiveness of behavioral programming, such techniques are not commonly employed in psychiatric inpatient settings. Several explanations for this have been proposed, including inadequate levels of training and competence in behavioral programming among prevalent treatment staff. This study employed a multiple choice inventory to assess behavioral knowledge among subjects representing several direct care disciplines commonly found in inpatient psychiatric settings. The results support assertions of relatively low levels of behavioral knowledge among disciplines that are most prevalent in such settings. The implications of these results for initiatives to enhance behavioral knowledge and skills are discussed.     

Taming the Heathkit-Votrax speech synthesizer

Three inexpensive text-to-speech synthesizers are described, intelligibility data from a pilot experiment are reported, and software is offered that has been written to facilitate the phonemic programming of the Heathkit-Votrax synthesizer.     

A Commodore 64-based interface system for the operant laboratory

A system of interfaces for the Commodore 64 (C-64) microcomputer for use in the operant laboratory is described. This system frees the experimenter from limitations on the number of I/O lines available on the user port of the C-64 and offers the control of operant chambers for a low cost. Subroutines in machine code to control the interfaces, offering millisecond timing of external events, are presented. A sample BASIC program demonstrates how the subroutines are called from BASIC to run a simple discrimination experiment.     

The orienting response,and future directions of its development

The orienting response (OR) is a specific behavioral act directed towards extraction of information from the environment. Head and eye movements represent only the tip of the iceberg of internal responses, which includes vascular modifications, EEG changes, and event-related potentials. Two mechanisms of the OR have to be differentiated: voluntary and involuntary. In the event-related potential, such a differentiation is expressed in mismatch negativity (involuntary effect) and processing negativity (voluntary effect). Single unit studies have shown that hippocampal neurones are simulating specific features of the OR as a response to novelty. Repeated presentation of stimuli results in a selective habituation of novelty detectors in hippocampus and of the OR. The trace of a standard stimulus formed at the level of hippocampal neurones matches the features of the standard stimulus and can be called a “neuronal model of the stimulus.” The OR is triggered by mismatch between the test stimulus and the elaborated neuronal model, and is activated by verbal instruction, by reinforcement during the initial stage of conditioned reflex elaboration, and by differentiation of signal and non-signal stimuli. A promising new area of practical application of the OR lies in the evaluation of a corridor of optimal functional state for efficient computer-based learning. Registration of the OR and defensive responses can be used for an objective evaluation of the functional state of the student, or, in a wider sense, of the industrial operator. New avenues of OR research are opened by recent techniques that isolate single-trial event related potentials, and their correlation with autonomic and behavioral manifestations of the OR. The combination of single unit recording with such isolated event related potentials can elucidate the neuronal basis of OR generation. Intracellular recording combined with dye injection can be used for analysis of the synaptic contacts involved in generation of the OR. Integration of macro and micro levels of OR organization can be achieved in a computerized model that can be used for simulation and planning of experiments. A step-by-step improvement of the model will accumulate knowledge about the OR as an important mechanism of information processing.