Sequence-Specific Impairment of Memory Formation by NCAM Antisense Oligonucleotides

The functional role of NCAM gene expression in memory formation was studied in the one-trial passive avoidance task in day-old chicks by pretraining injections of one of three different 18-mer end-protected oligonucleotides corresponding to positions 190-, 207-, and 332- of the NCAM Ig1 domain. Twenty-four-hour-old chicks were trained by pecking at a bitter-tasting bead and tested for avoidance 30 min, 3, 8, or 24 hr later. Memory retention was significantly reduced only in the group of animals injected with the NCAM antisense corresponding to position 207- (AS-ODN-207), and only if given twice, both immediately after hatching and 12 hr before training. This antisense was without effect on the general behavior of the chicks, training or acquisition, and did not produce observable neurotoxic damage. Under such conditions amnesia was evident by 3 hr after training and lasted until at least 24 hr after training. The two other tested oligonucleotides were without behavioral effect. To control for nonsequence-specific effects of AS-ODN-207, brains from injected and trained animals were processed for Western blotting and probed using anti-NCAM, anti-L1, and anti-actin antibodies. NCAM antisense corresponding to position 207- significantly reduced the level of NCAM, whereas the level of L1 and actin remained unchanged. These results confirm our earlier conclusion that NCAM is necessary for longer term memory retention.     

Self-Efficacy as a Mediator of Caregiver Coping: Development and Testing of an Assessment Model

Development and utilization of two self-efficacy measures thought to be relevant to stressed family caregivers, Caregiver Self-Care Self-Efficacy and Caregiver Problem-Solving Self-Efficacy, are described. Data obtained in the context of a psychoeducational intervention program are available for 217 caregivers of frail and/or cognitively impaired elders. Analyses of psychometric properties of the efficacy measures demonstrate good internal consistency and test-retest reliability for both measures. In addition, both measures of self-efficacy are related to depression as measured by the Beck Depression Inventory and caregiver distress as measured by the Zarit Burden Scale. Problem-Solving Self-efficacy also is related to subjective caregiver burden as measured by Zarit's Memory and Behavior Problem Checklist. Results are promising in terms of the utility of the measure and the application of self-efficacy theory to the caregiving situation. Limitations of these measures are discussed and suggestions made for improved second-generation self-efficacy scales.     

Body Size Beliefs and Weight Concerns Among Mothers and Their Adolescent Children

African American and White mother/adolescent pairs were examined for familial associations in body size and weight concerns. Mothers' and adolescents' estimates of adolescents' body mass index (BMI) were significantly correlated. Compared to boys, girls had greater body dissatisfaction, higher weight concerns, and perceived higher family/friend weight concerns. By race, White adolescents had more body dissatisfaction and greater concern about weight than African American adolescents. Four items explained 70.4% of the variance in adolescents' weight concern scores: adolescents' weight management practices, mothers' reports of adolescents' saying they were too fat, adolescents' perceptions of family/friends' weight concerns, and adolescents' body dissatisfaction. Our study suggests White girls are more concerned about their weight and perceive greater weight and dieting concerns among family/friends than African American girls.     

Variables affecting racial-identity salience among African Americans

The author clarified the African American racial-group identification process by addressing the issue of salience and its relationship to racial-group attitudes. A sample of 409 African American adults responded to surveys pertaining to their racial-group salience, racial-group attitudes, racial socialization, racial-group interaction, political activism, experiences of discrimination, and demographic data (e.g., sex, age, and income). The author tested 3 hypotheses: (a) Racial socialization and interaction with other African Americans are predictive of African American racial-identity salience; (b) discriminatory experiences are predictive of African American racial-identity salience; and (c) racial-identity salience is a stronger predictor of African American racial-group identification than are previously identified predictive variables (D. H. Demo & H. Hughes, 1990; V. L. Thompson Sanders, 1991, 1995). The results supported the 1st and 3rd hypotheses.     

COMPETITION BETWEEN POSITIVE AND NEGATIVE REINFORCEMENT IN THE TREATMENT OF ESCAPE BEHAVIOR

We compared the effects of reinforcing compliance with either positive reinforcement (edible items) or negative reinforcement (a break) on 5 participants' escape-maintained problem behavior. Both procedures were assessed with or without extinction. Results showed that compliance was higher and problem behavior was lower for all participants when compliance produced an edible item rather than a break. Treatment gains were achieved without the use of extinction. Results are discussed regarding the use of positive reinforcement to treat escape behavior.     

Reinforcement of compliance with respiratory treatment in a child with cystic fibrosis.

An 8-year-old boy with cystic fibrosis (CF), mental retardation, and autism exhibited noncompliance with respiratory treatments that were essential for the management of his CF. A treatment involving shaping cooperation while still allowing escape for aggression and avoidance behavior resulted in increases compliance with respiratory treatments and decreases in problem behavior. Treatment gains were maintained over 3 months.     

Subtypes of severe psychological distress among US Air Force remote warriors: A latent class analysis

US Air Force remote warrior personnel include a range of military personnel composed of remotely piloted aircraft aircrew, intelligence operators, and cyber warfare operators. Job duties in these professions entail long work hours, rotating shifts, and regular engagement in combat operations. Although research has identified a number of factors correlated with elevated burnout and emotional distress in this population, little is known about the unique needs of discrete subgroups of distressed personnel. In a sample of 7,550 US Air Force remote warriors, results of latent class analysis yielded four distinct classes. Three of the four reported moderately elevated burnout and job dissatisfaction but differed with respect to demographics and development career stage. The fourth group reported significantly higher levels of emotional distress, burnout, job dissatisfaction, and problems in living. This latter group was comparable to the mid-career group with respect to demographics, although this group had much lower levels of responsibility and indicators of career advancement. Results suggest that, among remote warrior personnel, there are several subtypes of elevated emotional distress. Prevention and intervention strategies that are matched to each subtype may yield better occupational and mental health outcomes than universal, “one size fits all” strategies.     

Evaluation of a Health Careers Program for Asian American and Pacific Islander High School Students

The authors evaluated a health careers program in a U.S. urban public high school. After small subgroups of the original sample were removed, participants included 162 Asian American and Pacific Islander students. Analyses of covariance indicated that, compared with the comparison group, the treatment group reported significantly higher levels of social support, school engagement, interest in learning, vocational expectations, and ethnic identity. Implications for multicultural counseling in schools are discussed. Los autores evaluaron un programa de carreras sanitarias en una escuela secundaria pública de Estados Unidos. Tras la eliminación de pequeños subgrupos de la muestra original, los participantes incluyeron 162 estudiantes Asiático‐Americanos e Isleños del Pacífico. Los análisis de covarianza indicaron que, comparado con el grupo de comparación, el grupo de tratamiento expresó unos niveles significativamente mayores de apoyo social, participación escolar, interés en el aprendizaje, expectativas vocacionales e identidad étnica. Se discuten las implicaciones para la consejería multicultural en escuelas.