Uptake of Cardiac Screening and Genetic Testing Among Hypertrophic and Dilated Cardiomyopathy Families

Cardiomyopathy is a genetically and clinically heterogeneous, life threatening disease which affects people of all ages. Recent guidelines provide recommendations for cardiac screening and genetic testing in at-risk relatives, but the uptake and impact of these measures in the United States is unknown. This is a single institution retrospective study that characterizes the uptake of cardiac screening and genetic testing for relatives of a cohort of 57 probands with hypertrophic (HCM) and dilated cardiomyopathy (DCM) who underwent both clinical evaluation and genetic testing. Cardiac screening was indicated for 302 relatives. One hundred and seventy-three (57 %) completed cardiac screening. Forty of the 57 probands were mutation positive and genetic testing was indicated for 213 relatives. Eighty-four (39 %) completed genetic testing. The uptake of cardiac surveillance was greater than the uptake of genetic testing (p?<?0.0001) among relatives of mutation positive probands. Within the group of at-risk, asymptomatic relatives of probands, cardiac screening and genetic testing were positive in 25 % and 40 % of cases, respectively. These data demonstrate the important role and utility of cascade cardiac screening and genetic testing in the care of patients and families with HCM or DCM. The approach to cardiac screening and genetic testing should be family-specific and requires expertise in the genetics of cardiomyopathy.     

Nest box entrance hole size can influence nest site selection and nest defence behaviour in Japanese tits

Animal Cognition - Birds have the ability to assess the risk of predation in their environment and adjust their antipredation strategies based on this risk information. However, whether nest site...     

提取抑制:来自听觉定向遗忘的证据

两个实验采用语音材料考察了词表表达方式下听觉通道的定向遗忘效应以及相应的机制。实验一中,采用2（组别）&#215;2（词表）混合实验设计获得了听觉通道的定向遗忘效应,但是较为模糊,部分数据显示可能是额外的被试个体差异导致的;实验二中,采用2（性别）&#215;2（词表）&#215;2（条件）&#215;2（科系）混合实验设计,严格控制了被试个体差异等因素,获得了较清晰的定向遗忘效应,且支持提取抑制理论。     

Parental involvement,adolescents' self‐determined learning and academic achievement in Urban China

Self‐determined learning is essential to academic success. The motivational resources development model argues that parents promote academic success in their children indirectly by nurturing self‐determined learner. In this study, applying a structural equation modelling and using data collected from 8th graders in Zhuhai, China (n = 1009) in 2012, we aim to answer 2 research questions: (a) What forms of parental involvement are highly correlated with self‐determined learning and (b) Can self‐determined learning fully mediate the relationship between parental involvement and students' academic performance? We find that parental leisure involvement is positively and significantly associated with the development of self‐determined learning, which in turn is significantly and positively correlated with academic achievement. Parental provision of structure or parental academic assistance is not significantly associated with students' self‐regulation and students' academic achievement.     

大学生自我认同感的差异

通过访谈法自编大学生自我认同感调查问卷,对某大学100名在校本科学生进行调查,统计分析得出：（1）男女大学生在家庭认同上差异最为显著（df=1,x^2=7．272．p〈O．01）,在姓名认同（df=l,x^2=3．898,p〈O．05）、性别认同（df=l,x^2=4.034,p〈0．05）、容貌认同（df=l,x^2=4．061,p〈O．05）也存在蓿显著的差异;（2）文理科大学生在家庭认同上存在着显著性差异（df=l,x^2=5．394,p〈O．05）;（3）城镇与农村大学生在学习成绩认同上存在着显著性差异（df=l,x^2=4.823,p〈0.05）。     

人与自然关系:作为中西文学发展的重要线索

人与自然关系是文学表现的重要母题。透过文学的发展,可以窥视出人类社会在社会实践推动下所走过的历史道路。本文意在通过中西文学发展中人与自然关系的描写,揭示人与自然关系的变化过程,并在历史的视野中审视生态批判的当代意义。     

A COMPARISON OF GROUP AND INDIVIDUAL SEXUAL ASSAULT VICTIMS

The experiences of 44 group sexual assault victims (multiple offenders, one victim) were compared with 44 individual sexual assault victims (one offender, one victim). Sexual assaults included various degrees of sexual victimization ranging from verbal coercion to rape. Participants were located from among a national sample of 3,187 college women. Group sexual assaults, compared to individual sexual assaults, were in general more violent, involved greater resistance from the victims, and were more likely to be perpetrated by strangers or relatives and to involve an experience which met the legal definition of rape. Group sexual assaults were less likely to involve multiple episodes by the same offender(s). Group sexual assault victims were more likely than individual sexual assault victims to seek police and crisis services, to have contemplated suicide, and to have sought therapy postassault. Despite these differences, the two groups were similar in the amount of drinking and drug use during the assault and their scores on standardized measures of psychological symptoms.     

Mobilization of Cognitive Resources and the Generation Effect

The generation effect refers to the memory advantage of words that have been generated rather than read. Such a read-generate comparison confounds qualitative task differences and raises methodological problems. A revised methodology is proposed circumventing these problems in that the encoding task is held constant and all stimuli have to be generated, but the degree of generativeness (i.e. the amount of cueing) is varied. In Experiment 1, 1, the (refined version of the) generation effect is demonstrated in a within-subjects design; with increasing generation activity left to the subject, free recall performance increases. No effect is obtained for degree of target masking. The same finding is replicated and shown to be independent of self-paced study time when generative activity is manipulated between subjects (Experiment 2) or within subjects (Experiment 3). As all learning trials involve generation, encoding time is controlled statistically, and free recall is used as a measure of memory, this refined generation effect cannot be explained as an artifact of selective attention or elaboration. Rather, generative activity seems to increase the mobilization of cognitive resources. This motivational account is supported by Experiment 4 showing an enhanced generation effect for positive mood.