CS-specific gamma,theta, and alpha EEG activity detected in stimulus generalization following induction of behavioral memory by stimulation of the nucleus basalis

Tone paired with stimulation of the nucleus basalis (NB) induces behavioral memory that is specific to the frequency of the conditioned stimulus (CS), assessed by cardiac and respiration behavior during post-training stimulus generalization testing. This paper focuses on CS-specific spectral and temporal features of conditioned EEG activation. Adult male Sprague-Dawley rats, chronically implanted with a stimulating electrode in the NB and a recording electrode in the ipsilateral auditory cortex, received either tone (6kHz, 70dB, 2s) paired with co-terminating stimulation of the nucleus basalis (0.2s, 100Hz, 80-105 microA, ITI approximately 45s) or unpaired presentation of the stimuli (approximately 200 trials/day for approximately 14 days). CS-specificity was tested 24h post-training by presenting test tones to obtain generalization gradients for the EEG, heart rate, and respiration. Behavioral memory was evident in cardiac and respiratory responses that were maximal to the CS frequency of 6kHz. FFT analyses of tone-elicited changes of power in the delta, theta, alpha, beta1, beta2, and gamma bands in the paired group revealed that conditioned EEG activation (shift from lower to higher frequencies) was differentially spectrally and temporally specific: theta, and alpha to a lesser extent, decreased selectively to 6kHz during and for several seconds following tone presentation while gamma power increased transiently during and after 6kHz. Delta exhibited no CS-specificity and the beta bands showed transient specificity only after several seconds. The unpaired group exhibited neither CS-specific behavioral nor EEG effects. Thus, stimulus generalization tests reveal that conditioned EEG activation is not unitary but rather reflects CS-specificity, with band-selective markers for specific, associative neural processes in learning and memory.     

Comorbidity and Related Factors Among Ethnically Diverse Substance Using Pregnant Women

Studies have established that comorbidity needs to be considered when assessing and treating substance-using clients. This study explores course of treatment, risk factors, and drug-related issues among 192 ethnically diverse pregnant women who were actively using drugs at admission to a residential treatment program. Findings revealed that course of treatment is more difficult for comorbid clients who perceived more treatment barriers than noncomorbid clients. Comorbid clients were more likely to have a history of attempting suicide but no more likely to have been reported for child abuse or charged with a crime. Comorbid clients reported greater severity of alcohol use but did not differ from noncomorbid clients regarding drug of choice. Comorbid clients were no more likely to leave against treatment advice, and noncomorbid clients were no more likely to complete treatment. Findings suggest that sensitivity to comorbidity issues is crucial to retaining comorbid clients in treatment.     

Sexualit?t und Internet

On the discussion about sexual internet activities, the professional and public discourses have been strongly polarized for a long time. Currently the trend is that online sexuality is to be seen in a differentiated and empirical manner. Next to undesired (e.g. assault by internet platform) or indirect (e.g. due to excessive pornography use by partners) confrontations with online sexuality, there is a broad spectrum of self-initiated sexual use of the internet. These are, for example reception of information sites, exchange of experiences, utilization of online sexual consultation and romantic relationships. On the other hand clinically relevant problems could accompany sexual internet use, such as cybersex addiction. Because of the mediatization in society ambulant patients in the psychotherapeutic practice are more informed about sexual internet use. For psychotherapists it is important to know the internet-specific details and the potential risks and chances for sexual behavior in order to know how to deal with the situation and if necessary to integrate the internet into the spectrum of web-based sexual therapeutic options.     

Role of centrifugal projections to the olfactory bulb in olfactory processing

While there is evidence that feedback projections from cortical and neuromodulatory structures to the olfactory bulb are crucial for maintaining the oscillatory dynamics of olfactory bulb processing, it is not clear how changes in dynamics are related to odor perception. Using electrical lesions of the olfactory peduncle, sparing output from the olfactory bulb while decreasing feedback inputs to the olfactory bulb, we demonstrate here a role for feedback inputs to the olfactory bulb in the formation of odor-reward associations, but not for maintaining primary bulbar odor representations, as reflected by spontaneous odor discrimination.     

The role of phonological recoding in orthographic learning

The objective of this research was to explore whether orthographic learning occurs as a result of phonological recoding, as expected from the self-teaching hypothesis. The participants were 32 fourth- and fifth-graders (mean age = 10 years 0 months, SD = 7 months) who performed lexical decisions for monosyllabic real words and pseudowords under two matched experimental conditions: a read aloud condition, wherein items were named prior to lexical decision to promote phonological recoding, and a concurrent articulation condition, presumed to attenuate phonological recoding. Later, orthographic learning of the pseudowords was evaluated using orthographic choice, spelling, and naming tasks. Consistent with the self-teaching hypothesis, targets learned with phonological recoding in the read aloud condition yielded greater orthographic learning than those learned with concurrent articulation. The research confirms the critical nature of phonological recoding in the development of visual word recognition skills and an orthographic lexicon.     

Community-Based Participatory Research for Improved Mental Health

Community-based participatory research (CBPR) focuses on specific community needs, and produces results that directly address those needs. Although conducting ethical CBPR is critical to its success, few academic programs include this training in their curricula. This article describes the development and evaluation of an online training course designed to increase the use of CBPR in mental health disciplines. Developed using a participatory approach involving a community of experts, this course challenges traditional research by introducing a collaborative process meant to encourage increased participation by special populations and narrow the parity gap in effective mental health treatment and services delivery.     

Reexamination of the Bem Sex-Role Inventory: The Interpersonal BSRI

The 40 masculine and feminine items of 746 Bern Sex-Role Inventory (BSRI; Bern, 1974) were subjected to a principal axis factor analysis with varimax rotation. Results revealed a four-factor solution, indicating that the original BSRI items do not provide two unidimensional ratings of femininity and masculinity. However, some support is given to Bern's initial two-factor thesis in that two principal factors emerged: one consisting of items that were originally identified as feminine, the other consisting of items that were originally identified as masculine. Content examination of the two principal factors resulted in an interpretation of the factors as Interpersonal Sensitivity and Interpersonal Potency. Internal consistency and validity of these two scales were examined and found to be adequate.     

Neural correlates of stimulus response and stimulus outcome shifting in healthy participants and MS patients

Introduction

Adaptation to changing situations can be mediated by two strategies: (1) Evaluation of a response and (2) Evaluation of outcome values in relation to objects. Previous studies indicate that response shifting is associated with a network comprising the left frontal cortex and parietal cortex connected by the superior longitudinal fascicle, whereas outcome evaluation is associated with a network consisting of the orbitofrontal cortex, amygdala and uncinate fascicle. However, these studies rarely compared both kinds of adaptation directly and existing fMRI studies with healthy subjects are not informative about the role of the two fiber systems.

Methods

We analyzed stimulus response shifting and stimulus outcome shifting in two studies, one fMRI-study on healthy participants and one study on patients with MS involving structural MRI (Diffusion Tensor Imaging, Voxel Based Morphometry, Ventricular volumetry). Two tasks were used, identical in presentation but different in instruction, controlling for effects of lower level processing. In the SRS task, participants had to perform a “Go” or “NoGo” response depending on a stimulus change: if the stimulus remained the same, they had to continue with the former type of response, if it changed they had to adapt their response pattern. In the SOS task they had to perform a “Go” response only if the presented stimulus corresponded to that of an internal alternating series.

Results

fMRI findings showed that SRS is related to a bilateral parietal-premotor network. In the left hemisphere the prefrontal cortex was also involved. SOS was lateralized to the right hemisphere, particularly to the anterior temporal pole and amygdala, and the inferior parietal cortex. MS patients impaired on this task suffered from lesions in the right uncinate fascicle and showed an enlarged right frontal lateral ventricle.

Conclusion

With physically identical tasks, a functional neuronal segregation can be demonstrated for stimulus response shifting (bilateral activations with a focus in the left prefrontal cortex) and stimulus outcome shifting (right anterior temporal lobe and right supramarginal gyrus).     

Neuropsychological Functioning in Children with Posttraumatic Stress Disorder

Posttraumatic stress disorder (PTSD) has been associated with deficits in the areas of verbal memory and learning, executive functioning, working memory, and attention in adults. Findings have been less consistent in the few studies examining neuropsychological functioning in childhood PTSD, which are often limited by comparing children with PTSD to children without trauma histories, making it unclear whether observed neuropsychological deficits are related to trauma exposure or to PTSD symptomatology. In an ethnically diverse sample of 62 children who witnessed intimate partner violence (n = 27 PTSD+ and 35 PTSD?), children with PTSD exhibited slower and less effective learning, heightened sensitivity to interference, and impaired effect of rehearsal on memory acquisition on the California Verbal Learning Test – Children's Version, a word list learning task. Both groups performed in the below average range on measures of executive functioning, attention, and intellectual ability.