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831.
Effects of mineralocorticoid receptor blockade on empathy in patients with major depressive disorder
Katja Wingenfeld Linn K. Kuehl Isabel Dziobek Stefan Roepke Christian Otte Kim Hinkelmann 《Cognitive, affective & behavioral neuroscience》2016,16(5):902-910
Background
The mineralocorticoid receptor (MR) is highly expressed in the hippocampus and prefrontal cortex and is involved in social cognition. We recently found that pharmacological stimulation of the MR enhances emotional empathy but does not affect cognitive empathy. In the current study, we examined whether blockade of the MR impairs empathy in patients with major depressive disorder (MDD) and healthy individuals.Methods
In a placebo-controlled study, we randomized 28 patients with MDD without psychotropic medication and 43 healthy individuals to either placebo or 300 mg spironolactone, a MR antagonist. Subsequently, all participants underwent two tests of social cognition, the Multifaceted Empathy Test (MET) and the Movie for the Assessment of Social Cognition (MASC), measuring cognitive and emotional facets of empathy.Results
In the MET, we found no significant main effect of treatment or main effect of group for cognitive empathy but a highly significant treatment by group interaction (p < 0.01). Patients had higher cognitive empathy scores compared to controls in the placebo condition but not after spironolactone. Furthermore, in the spironolactone condition reduced cognitive empathy was seen in MDD patients but not in controls. Emotional empathy was not affected by MR blockade. In the MASC, no effect of spironolactone could be revealed.Conclusion
Depressed patients appear to exhibit greater cognitive empathy compared to healthy individuals. Blockade of MR reduced cognitive empathy in MDD patients to the level of healthy individuals. Future studies should further clarify the impact of MR functioning on different domains of social cognition in psychiatric patients.832.
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834.
The likelihood of false recall in the Deese-Roediger-McDermott (DRM) paradigm was shown to depend on encoding context in two experiments. When fillers had been preselected to decrease the likelihood of encoding the critical lure's semantic features, false recall was virtually eliminated. However, when the same words were presented rearranged in different presentation orders, levels of false recall that were found in earlier DRM studies (Robinson & Roediger, 1997) were replicated. The role of encoding processes in the DRM paradigm was further explored with additional participants completing the experiment while thinking aloud. During encoding of word lists, participants verbalized semantic elaboration of the critical lure while studying the word lists. A path analysis demonstrated that participants' verbalization of critical lures during encoding reliably predicted their level of false recall. 相似文献
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837.
The Time Course of Attention: It Is Better Than We Thought 总被引:1,自引:0,他引:1
Christian N.L. Olivers 《Current directions in psychological science》2007,16(1):11-15
ABSTRACT— What is the time course of attention? Research using rapid-stimulus streams has suggested that it is rather slow: Attention takes half a second to recover from processing one thing before it can process the next. This period is referred to as the attentional blink , and it is thought to reflect a fundamental bottleneck in conscious processing. If this period does exist, such a limitation would have severe consequences in real-life situations in which multiple events may rapidly succeed each other (e.g., in traffic). However, findings that support the attentional blink are at odds with other findings indicating that attention is not reduced, but enhanced, following potentially important occurrences. The article reviews evidence that these opposite effects are actually closely related. The attentional blink is a consequence of selection mechanisms that are not severely limited, but have an adaptive function: They enhance perception in response to relevant information but suppress perception in response to irrelevant information. It means that humans are better geared for real life than was previously thought. 相似文献
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839.
Counterarguing persuasive messages requires active control processes (e.g., generation and application of contradictory information) similar to those involved in other forms of self-regulation. Prior research has indicated that self-regulation ability is a finite resource subject to temporary depletion with use, and so engaging in self-regulatory tasks could impair individuals’ ability to subsequently counterargue. Participants completed an initial task designed to deplete or not deplete their regulatory resources. Following the manipulation, participants read a message supporting a counterattitudinal policy. Results indicated that prior self-regulation reduced subsequent resistance, primarily when the message arguments were specious. Counterargument appears to be a self-regulatory process that can be undermined when self-regulatory resources have previously been diminished. 相似文献
840.
Christian Gostecnik 《Journal of religion and health》2007,46(4):580-590
Sexuality, with all its expressiveness, strongly reflects the deep vibrations that exist in the human psyche. In this article,
we try to show that sexuality can also manifest itself in the darkest realm of real addiction, and, as it were, can become
a cry for salvation; and further, that sexuality is the powerful reflection of an aching body, longing for purification, and
thus, salvation. 相似文献