STUDIES IN THE PSYCHOLOGICAL EFFECTS OF A NEW DRUG (DIETHYLPROPION): Subjective effects in the natural environment

Two doses diethylpropion, one dose pipradrol, one dose amobarbital and placebo were administered to 116 subjects, who rated their state on twenty variables. The variables were intercorrelated under pipradrol and pentymal. The correlation matrices were subjected to factor analysis. Four factors were found in both studies: Happiness, Alertness, Relaxation, and Flight of thoughts. There is some agreement between the two factor analyses. There were few significant effects of the drugs on factor scores, but the structure is quite unambiguous: pipradrol and diethylpropion are stimulating, and amobarbital tranquilizing.     

Response latencies in naming objects

After some preliminary analysis of what is involved in naming objects, in which the possible role of classificatory systems in the memory store is discussed, it is shown experimentally that there are consistent differences between the times taken to respond to presented objects by uttering their names, variations between the performances of different individuals being outweighed by variations due to the different objects. Moreover, there is a high consistency between different individuals as to the ordering of objects in respect of their naming latencies. It is further shown that a high correlation exists between the time taken to name an object and the frequency with which its name occurs in the language as a whole, as estimated in the Thorndike-Lorge Word List. Some implications of these findings are discussed, especially with reference to possible mechanisms by which presented objects are visually identified, and the appropriate names retrieved from the “word-store.”     

Memory performance awareness in younger and older adults

Reports on the course of memory-monitoring skills across adulthood are discrepant in conclusions and limited in scope. The purpose of this study was to build a large data base (3 samples and 7 different tasks) to assess performance awareness. Younger (19-41 years) and older (59-93 years) Ss estimated performance either before (i.e., predictions) or after (i.e., postdictions) completing each task. Predictions were less accurate than postdictions at both age levels, suggesting Ss monitored performance during the study-test cycle. Overall, the data suggested no consistent age effects in performance awareness: Age differences in monitoring occurred only in predictions and only for some tasks. Between-tasks differences in age effects could not be attributed to a single mediating mechanism like those suggested in previous reports. Why previous research has produced conflicting conclusions about metacognitive development in adulthood is discussed in light of these data.     

Adult age comparisons in the processing of event frequency information

The usual superiority in frequency-of-occurrence judgments of younger vs. older subjects was hypothesized to result from greater strategic encoding of the materials conveying frequency information. A subject-paced, visual search task was designed to control nontarget word encoding. Relative frequency judgments for the nontarget word pairs were equally accurate for younger and older subjects, and performance of both groups was above chance. Results suggest that strategic cover-task encoding can induce age differences in incidental frequency processing. Consistent with a nonoptimal as opposed to an optimal view, automatic processes require only minimal capacity for above-chance performance, but additional strategic resources can increase performance. When such additional resources are used more by younger than by older subjects, the former are better in frequency performance.     

Preserved organization of semantic attributes in Alzheimer's disease

This study investigated whether Alzheimer's disease (AD) disrupts the basic organization of the semantic attributes of concepts. Young and normal older subjects and AD patients were presented with a target concept followed by a stimulus word and were to decide whether the stimulus was related to the target. On those trials where it was, the stimulus was either a high-, medium-, or low-dominance attribute of the target. The higher the normative dominance, the more important the attribute to concept meaning. In all 3 subject groups, decision time varied as a function of dominance. The higher the dominance, the faster the decision. Attribute dominance affected the performance of AD patients more than that of normal subjects. These results suggest that AD patients retain their knowledge of the relative importance that the different attributes of a concept have for concept meaning.     

Reading Disability: A Model for the Genetic Analysis of Complex Behavioral Disorders

Family, linkage, and twin studies of reading disability are briefly reviewed, and evidence is presented from the twin component of the Colorado Reading Project that implicates genetic factors in the expression of reading disability. Recently developed behavioral genetic methodology is outlined, which provides an estimate of the magnitude of these genetic effects. The present report details the application of this methodology to reading performance data obtained from 96 identical twin pairs and 72 fraternal twin pairs in which at least one member of each pair was identified as reading disabled. Results indicate that approximately 50% of the reading deficit observed in the probands may be attributed to genetic factors. Although such an analysis assumes that reading disability is a homogeneous disorder, there may exist alternative forms with differing genetic etiologies. To test this hypothesis, the methodology can be extended to assess differential genetic etiology in alternative subgroups of disabled readers.     

Systematic 24-hr behavioral observations of sleep and wakefulness in a skilled-care nursing facility

Sleep patterns of aged, infirm, demented, chronically institutionalized residents of a skilled-care nursing facility were studied. The purpose of this naturalistic study was to describe sleep and wakefulness (S/W) within the limits afforded by brief behavioral observations and to examine homeostasis and diurnal rhythmicity of S/W as a function of psychoactive drug intake. Observers noted S/W every 15 min, 24 hr a day for 10 days in 24 Ss. Results indicated substantial individual variation in daytime hours. Daily and weekly variation within Ss was minimal. Sleep was least likely near sunset. Ss on psychoactive drugs showed dampened diurnal variation in S/W rhythms. In Ss not on such drugs, there was a suggestion of homeostasis of S/W between sleep during the morning and evening hours. Results are discussed methodologically (viability of approach), theoretically (age-related change in sleep), and practically (potential treatments).