PLURALIST METAPHYSICS

Philosophical Studies -     

The mediating role of anxiety in self-reported somatic complaints of depressed adolescents

This study examined the mediating role of anxiety in the self-reports of somatic complaints in 96 depressed adolescent inpatients. Sixty-four subjects with major depressive episodes and comorbid anxiety disorders (MDE-A) determined from the Diagnostic Interview for Children and Adolescents-Revised (DICA-R) reported significantly more somatic complaints than 32 adolescents having major depressive episodes without comorbid anxiety (MDE). An analysis of covariance demonstrated that, with anxiety symptoms controlled, MDE and MDE-A groups did not differ significantly in somatic complaints. A hierarchical multiple-regression analysis revealed that, with demographic and anxiety symptoms controlled, depressive symptoms did not contribute to the explanation or prediction of somatic complaints. The results suggest that anxious, but not depressive symptoms, are independently associated with somatic complaints. The results are discussed in light of new affective models of psychopathology.     

Challenges confronting cross-sex friendships: “Much ado about nothing?”

This research was an investigation into four challenges purported to confront cross-sex friends. One hundred and thirty eight individuals (females = 86, males = 52) completed two surveys designed to explore the extent to which the sexual, emotional bond, audience, and equality challenges were present in their cross-sex friendships. Over 98% of the participants were heterosexual, 99% were Caucasian, and approximately 5% were Hispanic. Data gathered from the first survey were analyzed using a three-way analysis of variance, with gender, type of friendship, and romantic status as the independent variables, and three of the four challenges as the dependent variables. The first survey also included open-ended questions designed to explore the nature and existence of the challenges. The second survey was in a diary format. Respondents kept a frequency count for three weeks of discussions they had with their cross-sex friend concerning the challenges, and thoughts that they had as individuals concerning those challenges. Results from both surveys indicate that though the challenges exist and have powerful effects on a small percentage of individuals in cross-sex friendships, for the majority of participants the challenges are not perceived as salient.     

Data selection and responsible conduct: Was millikan a fraud?

This paper addresses a problem in reporting scientific research. The problem is how to distinguish between justifiable and unjustifiable data selection. Robert Millikan is notorious for an infamous remark that he used all his data when in fact he had used a selection. On this basis he has been accused of fraud. There is a tension here — historians and his defenders see his selection as understandable and legitimate, while current statements about the Responsible Conduct of Research imply his selection was illegitimate. This paper discusses two main issues that arise in assessing his conduct, whether he was intentionally misleading and whether he actually did mislead the scientific community about some facts of nature. It is argued that he was not intentionally misleading, and that it is unlikely that he misled the scientific community.     

Sentence Context and Word Recognition in Children with Average Reading Ability and with a Specific Reading Disability

The inhibitory and facilitatory effects of context on word recognition were investigated in 24 8-to 10-year-old children with a specific reading disability in comparison with a group of 24 children matched for reading ability and a group of 24 children matched for chronological age. To avoid confounding the effects of reading level with those of word difficulty, target words of equivalent relative familiarity for each participant were presented in congruous, neutral, and incongruous sentence contexts. In agreement with previous studies, there was clear evidence of both general inhibitory and facilitatory effects. In contrast to previous findings, however, reading level did not have a major impact on the inhibition of word recognition in incongruous contexts compared with neutral contexts, although it may have led to greater facilitation in congruous contexts compared with neutral contexts. Although further research is required, these results suggest that if reading-age appropriate materials are selected, less skilled readers and those with a reading disability may not be as influenced by context as has been claimed previously.     

Pharmacological dissociation of memory: anisomycin, a protein synthesis inhibitor, and leupeptin, a protease inhibitor, block different learning tasks

Inhibition of protein synthesis by anisomycin for a short duration impairs memory of a one-trial inhibitory avoidance task in rats. Memory of escape conditioning involving eight trials is disrupted only if the duration of protein synthesis is prolonged by repeated injections. In marked contrast, olfactory memory of rats trained on two odor discriminations is not affected by anisomycin even if the duration of inhibition is prolonged and the number of trials is reduced to a minimum. In previous work, leupeptin, a thiol proteinase inhibitor, was shown to impair olfactory discrimination learning, but left inhibitory and avoidance conditioning intact. Together, these results provide a pharmacological double dissociation of memory, and suggest that the same chemistries, or mixtures of chemistries, may not be involved in all types of memory.     

Exploration and avoidance in rats with lesions in amygdala and piriform cortex

Lesions localized to specific areas of the amygdala and overlying cortex in rats produced differential effects in several behavioral tasks. Three different types of lesions were tested: central, basolateral, and cortex lateral to the amygdala. Lesions restricted to the central nucleus produced increased activity on all parameters studied in an open-field test, but the other two groups were not changed. In one-way active avoidance all three groups with lesions showed deficits. The most pronounced change was observed in the central group. All groups showed the same degree of retention loss, but in forced extinction of one-way active avoidance after retraining, the cortical and basolateral groups were most defective. A fear-reduction hypothesis is proposed for the central lesion. The basolateral and cortical areas may be more specifically involved in passive avoidance behavior.     

Differential indications for desipramine--results of a controlled multiclinical study]

The antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective symptoms, which was not detectable for the inhibition of drive. The tachythymoleptic action of desipramine is discussed with reference to these results. Evaluation of the possibility of controlling affects shows different ranges of activity of desipramine and imipramine, with desipramine influencing especially negative psychoenergetic symptoms in the area of drives and emotions and imipramine, restrictive symptoms in addition to differential phenomena of the psychomotor expression.