Clinical Utility of Expanded Carrier Screening: Reproductive Behaviors of At-Risk Couples

Expanded carrier screening (ECS) analyzes dozens or hundreds of recessive genes to determine reproductive risk. Data on the clinical utility of screening conditions beyond professional guidelines are scarce. Individuals underwent ECS for up to 110 genes. Five-hundred thirty-seven at-risk couples (ARC), those in which both partners carry the same recessive disease, were invited to participate in a retrospective IRB-approved survey of their reproductive decision making after receiving ECS results. Sixty-four eligible ARC completed the survey. Of 45 respondents screened preconceptionally, 62% (n = 28) planned IVF with PGD or prenatal diagnosis (PNDx) in future pregnancies. Twenty-nine percent (n = 13) were not planning to alter reproductive decisions. The remaining 9% (n = 4) of responses were unclear. Of 19 pregnant respondents, 42% (n = 8) elected PNDx, 11% (n = 2) planned amniocentesis but miscarried, and 47% (n = 9) considered the condition insufficiently severe to warrant invasive testing. Of the 8 pregnancies that underwent PNDx, 5 were unaffected and 3 were affected. Two of 3 affected pregnancies were terminated. Disease severity was found to have significant association (p = 0.000145) with changes in decision making, whereas guideline status of diseases, controlled for severity, was not (p = 0.284). Most ARC altered reproductive planning, demonstrating the clinical utility of ECS. Severity of conditions factored into decision making.     

Book reviews

Dewsbury, D.A. (Ed.). (1990). Contemporary issues in comparative psychology. Sunderland, MA: Sinauer. Pp. xiii + 509. ISBN 0-87893-137-6. £21.95 (paperback).

Goudie, A.J., & Emmett-Oglesby, M. W. (Eds.). (1989). Psychoactive drugs: tolerance and sensitization. Clifton, NJ: The Humana Press. Pp. 600. ISBN 0-89603-148-9. £46.00.

Edwards, G. & Lader, M. (1990). The nature of drug dependence. Society for the Study of Addiction Monograph No 1. Oxford: Oxford University Press. Pp. 240. ISBN 0-19-261772-9. £30 (hardback).

Lieberman, D.A. (1990). Learning, behavior and cognition. Belmont, CA: Wadsworth, Inc. Pp. xx + 500. ISBN 0-534-12318-X. £16.95 (hardback).

Krasnegor, N.A. & Bridges, R. S. (Eds.). (1990). Mammalian parenting. Biochemical, neurobiological, and behavioral determinants. New York, Oxford: Oxford University Press. Pp. 502. ISBN 0-19-505600-0. £60.00 (hardback)     

Ant Colony Optimization and Local Weighted Structural Equation Modeling. A Tutorial on Novel Item and Person Sampling Procedures for Personality Research

Measurement in personality development faces many psychometric problems. First, theory‐based measurement models do not fit the empirical data in terms of traditional confirmatory factor analysis. Second, measurement invariance across age, which is necessary for a meaningful interpretation of age‐associated personality differences, is rarely accomplished. Finally, continuous moderator variables, such as age, are often artificially categorized. This categorization leads to bias when interpreting differences in personality across age. In this tutorial, we introduce methods to remedy these problems. We illustrate how Ant Colony Optimization can be used to sample indicators that meet prespecified demands such as model fit. Further, we use Local Structural Equation Modeling to resample and weight subjects to study differences in the measurement model across age as a continuous moderator variable. We also provide a detailed illustration for both tools with the Neuroticism scale of the openly available International Personality Item Pool – NEO inventory using data from the UK sample (N = 15 827). Combined, both tools can remedy persistent problems in research on personality and its development. In addition to a step‐by‐step illustration, we provide commented syntax for both tools. © 2019 European Association of Personality Psychology     

Increased chronic stress predicts greater emotional negativity bias and poorer social skills but not cognitive functioning in healthy adults

Background and Objectives: Chronically stressed individuals report deficits spanning cognitive and emotional functioning. However, limitations to clinical populations and measures of stress have impeded the generalisability and scope of results. This study investigated whether chronic stress predicted cognitive and emotional functioning, and whether these relationships differed between males and females, in a large representative sample of healthy participants.

Design: Cross-sectional study.

Method: 1883 healthy adults sampled from the Brain Resource International Database reported stress using the 21-item Depression Anxiety Stress Scales. Participants then completed a cognitive and emotional assessment battery (IntegNeuro), as well as questionnaires related to sleep, emotional functioning, and self-regulation.

Results: In contrast to previously reported results, chronic stress did not predict cognitive functioning. However, higher stress predicted a greater negativity bias and poorer social skills, confirming previous research identifying these links.

Conclusions: Cognitive deficits related to stress are absent in healthy participants when stress is measured using the 21-items Depression Anxiety Stress Scales. Identifying how chronic stress is associated with aspects of emotional functioning can lead to personalized interventions for individuals to better manage the negative outcomes resulting from stress.     

SPIRITUALITY AND TECHNOLOGY: A THREEFOLD PHILOSOPHICAL REFLECTION

Despite the prominent role that technology plays in twenty-first-century societies, the intersections between spirituality and technology have been poorly analyzed. This article develops a cross-reflection between these two key anthropological aspects, using a philosophical approach that structures the analysis along three classical categories: transcendence, immanence, and relationality. Drawing from ideas of philosophers, such as Heidegger and Merleau-Ponty, the article sheds light on problematic aspects of technology that spirituality helps identify and for which it suggests solutions. Symmetrically, the analysis shows commonly inadvertent aspects of spirituality that technology brings to the fore. All in all, spirituality appears as an essential dimension to cultivate in technological societies, while technology might reveal spirituality as richer and deeper than has been apparent in traditional settings.