Reduction of inflammatory pain in female rats after NR2B NMDA cortical antagonism

Studies have shown that N-methyl-D-aspartate (NMDA) receptors play a critical role in pain processing at different levels of the central nervous system. In this study, we used female adult Wistar rats to examine the effects of antagonizing the NR2B subunit of the NMDA receptor in phasic and tonic pain processes. All the rats underwent stereotaxic surgery for cortical cannula implantation and after at least one week of recovery, rats performed behavioral tests. For evaluating the effects of drugs on motor coordination rats were tested in the rotarod apparatus. Moreover, rats were evaluated in the paw withdrawal latency (PWL) to a noxious thermal stimulus. Furthermore, rats were tested in the formalin-pain test. Rats that received the NR2B antagonist Ro 25-6981 before and after formalin injection showed significantly reduced pain responses in the formalin test, as compared with female control rats (p<0.05). In contrast, no differences among groups were found in the phasic pain test (Hargreaves) and the rotarod test. Taken together, these results suggest that cortical antagonism of the NR2B subunit of NMDA receptors is able to reduce inflammatory pain levels not only before, but after the formalin injection in females at different phases of the estrous cycle.     

Grapheme–color synesthesia can enhance immediate memory without disrupting the encoding of relational cues

Previous evidence has suggested that grapheme–color synesthesia can enhance memory for words, but little is known about how these photisms cue retrieval. Often, the encoding of specific features of individual words can disrupt the encoding of ordered relations between words, resulting in an overall decrease in recall accuracy. Here we show that the photisms arising from grapheme–color synesthesia do not function like these item-specific cues. The influences of high and low word frequency on the encoding of ordered relations and the accuracy of immediate free recall were compared across a group of 10 synesthetes and 48 nonsynesthetes. The main findings of Experiment 1 showed that the experience of synesthesia had no adverse effect on the encoding of ordered relations (as measured by input–output correspondence); furthermore, it enhanced recall accuracy in a strictly additive fashion across the two word frequency conditions. Experiment 2 corroborated these findings by showing that the synesthetes only outperformed the nonsynesthetes when the materials involved words and letters, not when they involved digits and spatial locations. Altogether, the present findings suggest that synesthesia can boost immediate memory performance without disrupting the encoding of ordered relations.     

Identifying outpatients with entrenched suicidal ideation following hospitalization

The purpose of this study was to identify outpatients who experience entrenched suicidal ideation following inpatient psychiatric hospitalization. Our findings suggest that the use of a suicidal ambivalence index score was helpful at discriminating those who reported significantly greater ratings of suicidal ideation across a 1-year period of time, whereas splitting patients based upon suicide attempt history yielded nonsignificant results. Similar findings resulted from a dimensional analytic approach, as well. Application of the suicidal ambivalence index may help administrators identify patients who require more intensive clinical services to resolve their suicidal ideation.     

Effects of sleep on positive,negative and neutral valenced story and image memory

During sleep, emotional memories are preferentially strengthened. However, most studies on sleep and emotional memory focus on comparing negative valence with neutral valence stimuli. This study compared the sleep-dependent memory effects for stories and images, each comprising negative, neutral, and positive stimuli. It was hypothesized that a sleep effect would be seen for negatively and positively valenced stimuli. A novel story memory task (comprising three stories), and photographs from the Nencki Affective Picture database were presented for learning to 61 healthy adults (ages 18–25). They were tested for memory on the two tasks immediately, and then again after either a 2-hr nap (n = 31; 17 women, 14 men) or 2-hr wake period (n = 30; 13 women, 17 men). At second testing, the sleep condition had significantly better recall compared to the wake condition on both tasks. There was a relationship with valence only for the story task, with better performance for the sleep condition on the negatively and positively valenced texts, but not on the neutral text. There were no significant relationships between memory measures and sleep-stage duration and EEG power variables. The story memory findings support the hypothesis that memory consolidation prioritizes emotional memory, whether positively or negatively valenced.     

Would you Value a few More Hours of work? Underemployment and Subjective Well-Being Across Chilean Workers

Underemployment has gained attention in recent years because of its effects on health and well-being (life satisfaction), it is a widespread phenomenon in the labor force that affects not only workers, but also households, companies and governments. This paper explores the relationship between underemployment and subjective well-being for a representative sample of Chilean workers using an ordered probit model. Also, by using different underemployment definitions and a latent class ordered probit model we analyze the observed and unobserved heterogeneity in this relationship. Finally, we assess the monetary valuation of well-being costs by estimating the amount of money that a worker is willing to accept in order to bear the potential negative effects of underemployment on well-being. Our results find a negative relationship between underemployment and subjective well-being, as the average worker is willing to accept an increase of CLP$64,009 (roughly 30.5% of the minimum wage) in her/his monthly wage for being underemployed. If we take into account the observed and unobserved heterogeneity, our results identify a group that is not sensitive to underemployment, while others are willing to accept an increase of CLP$146,622 in her/his monthly wage for being underemployed. Our work highlights the importance of well-being in the workplace and has implications for labor flexibility legislation and the empowerment of workers. Heterogeneous responses to underemployment imply that one-size-fits-all policies to regulate working hours might not suffice.

     

Implementation Intentions Improve Prospective Memory and Inhibition Performances in Older Adults: The Role of Visualization

Implementation intentions have been shown to be a very effective strategy in improving prospective memory in older adults. However, their efficacy in improving inhibition has never been assessed in aging. We thus examined the efficacy of implementation intentions in a prospective memory task and an inhibition task in 87 older participants. Following a crossover design, half of the participants were instructed to form an implementation intention in the prospective memory task, the other half in the inhibition task. The moderating role of working memory, visualization and verbalization habits, and impulsivity were also assessed. Regression analyses revealed that for both tasks, participants benefited from implementation intentions but only if they were used to using visual strategies in daily life. The efficacy of implementation intentions was not moderated by working memory, impulsivity, or the use of verbal strategies in everyday life. Copyright © 2014 John Wiley & Sons, Ltd.     

One Foot Out of the Nest: How Parents and Friends Influence Social Perceptions in Emerging Adulthood

Attachment theory proposes that representations of attachment figures are transferred between relationships, resulting in stable relational experiences. The current study used a transference paradigm to examine how parental and best friend attachment representations influence perceptions of new relationship partners in emerging adulthood. We discovered that close friendships influenced attachment anxiety and avoidance experienced specifically with friend-like others, while parental relationships affected feelings of anxiety toward a variety of people. Several relationship factors, such as the importance of the friend relationship, moderated the transference process. Our findings suggest that emerging adults’ current relationships have an impact on their reactions toward novel individuals, and emerging adults’ feelings about their existing relationship partners color their future social experiences.     

White matter maturation supports the development of reasoning ability through its influence on processing speed

The structure of the human brain changes in several ways throughout childhood and adolescence. Perhaps the most salient of these changes is the strengthening of white matter tracts that enable distal brain regions to communicate with one another more quickly and efficiently. Here, we sought to understand whether and how white matter changes contribute to improved reasoning ability over development. In particular, we sought to understand whether previously reported relationships between white matter microstructure and reasoning are mediated by processing speed. To this end, we analyzed diffusion tensor imaging data as well as data from standard psychometric tests of cognitive abilities from 103 individuals between the ages of 6 and 18. We used structural equation modeling to investigate the network of relationships between brain and behavior variables. Our analyses provide support for the hypothesis that white matter maturation (as indexed either by microstructural organization or volume) supports improved processing speed, which, in turn, supports improved reasoning ability.     

Aging and Situation Model Updating

The aim of this study was to investigate age differences in narrative comprehension and memory, with a focus on the updating of situation models during comprehension. While there are large effects of aging on memory for propositional textbase information, there is very little evidence that older adults have difficulty at the situation model level. Because described events are often dynamic, a comprehender must consistently update their situation model to make it consistent with the new information. The current experiments investigated whether there are any age differences associated with the ability to update a situation model along the spatial and temporal dimensions. Although updating effects were observed, they were largely not influenced by age. The relation of these findings to an understanding of older adults’ language comprehension and memory performance is discussed.