Substantia nigra role in fear conditioning consolidation

The substantia nigra (SN) is known to be involved in the memorization of several conditioned responses. To investigate the role of the SN in fear conditioning consolidation this neural site was subjected to fully reversible tetrodotoxin (TTX) inactivation during consolidation in adult male Wistar rats which had undergone fear training to acoustic CS and context. TTX was stereotaxically administered to different groups of rats at increasing intervals after the acquisition session. Memory was assessed as conditioned freezing duration measured during retention testing, always performed 72 and 96 h after TTX administration. In this way there was no interference with normal SN function during either acquisition or retrieval phases, so that any amnesic effect could be due only to consolidation disruption. The results show that SN functional integrity is necessary for contextual fear response consolidation up to the 24-h after-acquisition delay. On the contrary SN functional integrity was shown not to be necessary for the consolidation of acoustic CS fear responses. The present findings help to elucidate the role of the SN in memory consolidation and better define the neural circuits involved in fear memories.     

Part-set cuing in option generation

Memory research on the part-set cuing effect has shown that providing some of the to-be-remembered items as cues is not always beneficial and, in some cases, may even hurt retrieval. However, part-set cuing has been sparsely investigated in option generation tasks. Thus, limited empirical evidence for the existence of the effect in option generation is available, and no convincing explanation has been provided yet. In order to fill these gaps, we carried out four experiments. In Experiment 1A, we observed a significant decrease in option generation performance when potential options were presented as cues. Experiment 1B showed that the effect can also be obtained in older adults. Experiments 2A and 2B provided evidence compatible with an inhibition-based explanation of the observed effects.     

Differential roles of the basolateral amygdala and nucleus basalis magnocellularis during post-reactivation contextual fear conditioning reconsolidation in rats

The roles of the basolateral amygdala and nucleus basalis magnocellularis in fear conditioning reconsolidation were investigated by means of tetrodotoxin bilateral inactivation performed 96 h after conditioning, immediately after reactivation training. Footshocks of 1.2 mA intensity were employed to induce the generalization phenomenon. Basolateral amygdala inactivation disrupts the contextual fear response and its generalization but not acoustic CS trace retention, when measured 72 and 96 h after tetrodotoxin administration. Nucleus basalis magnocellularis functional inactivation does not affect memory post-reactivation phase of any of the three conditioned fear responses. The present findings show a differential role of the two structures in fear memory reconsolidation and can be a starting point for future investigation of the neural circuits subserving generalization.     

Assessing Interpersonal Profiles Associated With Varying Levels of Effortful Control

Research has linked individual differences in effortful control (EC) with variations in interpersonal functioning in children and adolescents. Using the Inventory of Interpersonal Problems–Short Circumplex (Hopwood, Pincus, DeMoor, & Koonce, 2008), this study investigated interpersonal problem profiles associated with EC in 763 nonclinical young adults. We found that individuals with low EC reported intrusive interpersonal problems and high levels of interpersonal distress, whereas individuals with high EC reported cold interpersonal problems but low levels of interpersonal distress. Results suggest that EC might play an important role in shaping interpersonal functioning.     

The semantic structure of vision verbs: A psycholinguistic investigation of Italian

The aim of the present study was to investigate the semantic dimensions that contribute to the mental representation of vision verbs in Italian. In Experiment 1, a group of experts (psychology faculty members) was asked to list the semantic attributes necessary for describing a set of Italian vision verbs (Phase 1) and a group of students rated the extent to which each of these attributes was appropriate to characterise these verbs (Phase 2). In Experiment 2, the conceptual organisation of vision verbs was assessed through Multidimensional Scaling (MDS) using direct judgements of pairwise similarity between vision verbs (e.g., “vedere-guardare”). The results show that six of the attributes generated in Phase 1 are useful for describing the pattern of similarity ratings obtained in Experiment 2, namely attention, certainty, cognitive content, control, duration, and intentionality.