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141.
Estradiol (17beta-E2) can have mnemonic-enhancing effects; however, its mechanisms for these effects are not well-understood. The present studies examined effects of 17beta-E2 and selective estrogen receptor modulators (SERMs) on emotional and spatial memory of female, Long-Evans rats. First, whether or not 17beta-E2 has dose-dependent effects on inhibitory avoidance memory was investigated. Only the highest concentration of 17beta-E2 examined (10 microg), which produces physiological concentrations of E2, was effective at enhancing inhibitory avoidance memory (Experiment 1). Further studies were designed to elucidate whether SERMs may produce mnemonic effects similar to those of 17beta-E2. Compounds utilized were, the ERalpha-selective SERMs, propyl pyrazole triol (PPT) or 17alpha-E2, the ERbeta-specific SERMs, diarylpropionitrile (DPN) or 7,12-dihydrocoumestan (coumestrol), or vehicle (oil). Post-training administration of 10 microg 17beta-E2 or coumestrol enhanced memory in the inhibitory avoidance task compared to vehicle (Experiment 2). Memory in the water maze was enhanced by post-training administration of 17beta-E2, coumestrol, or DPN, compared to vehicle (Experiment 3). Co-administration of 17alpha-E2&DPN enhanced inhibitory avoidance memory similar to that seen following 17beta-E2 or coumestrol (Experiment 4). Administration of E2 2 h post-training was not effective at enhancing memory in the inhibitory avoidance or water maze tasks (Experiment 5). Lordosis of rats was enhanced by 17beta-E2, 17alpha-E2, or PPT, compared to vehicle (Experiment 6). These data suggest that: E2's actions at ERbeta, rather than ERalpha, may enhance spatial memory, E2's actions at ERalpha can facilitate sexual behavior, and that E2's actions involving both ERalpha and ERbeta may be important for emotional memory. 相似文献
142.
Over the last decade, there has been an interest in the impact of visual illusions on the control of action. Much of this work has been motivated by Milner and Goodale's two visual system model of visual processing. This model is based on a hypothesized dissociation between cognitive judgments and the visual control of action. It holds that action is immune to the visual context that provides the basis for the illusion-induced bias associated with cognitive judgments. Recently, Glover has challenged this position and has suggested that movement planning, but not movement execution is susceptible to visual illusions. Research from our lab is inconsistent with both models of visual-motor processing. With respect to the planning and control model, kinematic evidence shows that the impact of an illusion on manual aiming increases as the limb approaches the target. For the Ebbinghaus illusion, this involved a decrease in the time after peak velocity to accommodate the 'perceived' size of the target. For the Müller-Lyer illusion, the influence of the figure's tails increased from peak velocity to the end of the movement. Although our findings contradict a strong version of the two visual systems hypothesis, we did find dissociations between perception and action in another experiment. In this Müller-Lyer study, perceptual decisions were influenced by misjudgment of extent, while action was influenced by misjudgment of target position. Overall, our findings are consistent with the idea that it is often necessary to use visual context to make adjustments to ongoing movements. 相似文献
143.
Romero LJ Garry PJ Schuyler M Bennahum DA Qualls C Ballinger L Kelly V Schmitt C Skipper B Ortiz IE Rhyne RL 《Journal of genetic counseling》2005,14(2):141-150
The purpose of our study is to assess the emotional responses to disclosing APO E genotype to asymptomatic older adults at increased risk for Alzheimer disease (AD). This is a longitudinal cohort study of volunteer subjects who were aged 50 years or over, asymptomatic for (AD), had a family history of AD, passed a psychological assessment, and participated in pre- and post-test genetic counseling and three follow-up visits over 10 months. We analyzed responses by three emotional constructs: depressed, worried, and relieved. Three hundred and twenty-eight subjects were screened, 76 received their APO E genotype. When emotional responses occurred it was immediate, between baseline and the 1 month follow-up. Emotional reactions did not change significantly past 1 month. Our results suggest that for emotionally stable persons, disclosing results of their APO E genotype, high risk subjects did not report more depression or worry and low risk subjects felt relieved by knowing the results. Future studies should evaluate the risks of disclosure to family members involved in the diagnostic work-up of a relative and include subjects from a broader range of emotional stability and socioeconomic background. 相似文献
144.
Cheryl A Logan 《Integrative Physiological and Behavioral Science》2005,40(4):169-181
The breeding of albino rats had an enormous impact on experimental psychology in the twentieth century. Rats were, and for many questions still remain, the "standard animal" for laboratory research in neurology, psychology, and physiology. Albert Meyer was one of the figures most responsible for developing the albino rat as an experimental model. Despite Meyer's pioneering work with albino rats, his rat research has received only sparse attention. Little is known about the way in which the animal served Meyer's more famous psychiatric program. In this article, the author discusses the role that albino rats played in Meyer's animal research. He then turn to the contrast between the way in which Meyer viewed the animal's role in research and the way rats were later used as a laboratory "standard" to assure scientific generality. This comparison highlights the changes that occurred in comparative psychology in the twentieth century, and it further clarifies some of the concerns associated with the use of animal models today. 相似文献
145.
We prospectively examined the relationship between individuals' belief in a just world and their desire for revenge against the perpetrators of the September 11 terrorist attacks against the United States. Eighty-three undergraduate students who had completed a measure of just-world beliefs prior to the terrorist attacks were assessed approximately 2 months following the attacks. The more strongly they had endorsed just-world beliefs prior to the attacks, the more distressed they felt about the attacks and the more they desired revenge. Furthermore, the relationship between belief in a just world and the desire for revenge was mediated by feelings of distress in response to the terrorist attacks. The results point to the importance of justice beliefs in understanding responses to the terrorist attacks. 相似文献
146.
Racial/ethnic minority women who come to identify as lesbian must confront the norms and expectations of both the majority and minority cultures in which they live. This article reports findings from a diverse sample of nearly 450 women and examines the effects of race/ethnicity on sexual identity development in African American, Latina, and White lesbians. African American and Latina respondents differed little in the timing and disclosure of lesbian identity; comparisons between women of color and White women revealed substantial variability. Findings are discussed in terms of their implications for practice with lesbians of color. 相似文献
147.
Skinner DM Etchegary CM Ekert-Maret EC Baker CJ Harley CW Evans JH Martin GM 《Journal of experimental psychology. Animal behavior processes》2003,29(1):3-13
Rats were trained to locate food in a response, direction, or place problem on an open field located at 2 positions. In Experiment 1, both the response and direction groups solved the problem. The place group failed to solve the task in approximately 300 trials. Experiment 2 demonstrated that rats need distinguishable start points to solve a place problem when neither a response nor a direction solution is available. Findings from Experiment 3 suggest that a combination of path traveled and distinct cues help to differentiate start points. Experiment 4 replicated the findings using a T maze. These results suggest "place" solutions are difficult for rats. The data are discussed with respect to conditional learning and modern spatial mapping theory. 相似文献
148.
In an attempt to increase the breadth offeminist perspectives assessed by the FeministPerspectives Scale (FPS2; Henley, Meng, O'Brien,McCarthy, & Sockloskie, 1998), we developed andpsychometrically evaluated a new subscale that assesses lesbianfeminist attitudes. As do the six other subscales of theFPS2, the Lesbian Feminist subscale includes 10attitudinal and 3 behavioral items. We conducted 3 studies with 287 respondents (58% EuropeanAmerican, 15% Latino, 13% Asian, and 6% AfricanAmerican); 88% were women and most were collegeeducated. Findings from these preliminary psychometricevaluations support the subscale's reliability (Cronbach'salpha = .91) and validity. We offer recommendations forthe scale's use and discuss its potentiallimitations. 相似文献
149.
James E. Carr Jon S. Bailey Cheryl L. Ecott Kim D. Lucker Timothy M. Weil 《Journal of applied behavior analysis》1998,31(3):313-321
We conducted a parametric analysis of response suppression associated with different magnitudes of noncontingent reinforcement (NCR). Participants were 5 adults with severe or profound mental retardation who engaged in a manual response that was reinforced on variable-ratio schedules during baseline. Participants were then exposed to NCR via multielement and reversal designs. The fixed-time schedules were kept constant while the magnitude of the reinforcing stimulus was varied across three levels (low, medium, and high). Results showed that high-magnitude NCR schedules produced large and consistent reductions in response rates, medium-magnitude schedules produced less consistent and smaller reductions, and low-magnitude schedules produced little or no effect on responding. These results suggest that (a) NCR affects responding by altering an establishing operation (i.e., attenuating a deprivation state) rather than through extinction, and (b) magnitude of reinforcement is an important variable in determining the effectiveness of NCR. 相似文献
150.
The main task of generativity–stagnation, Erik Erikson's seventh stage of normative psychosocial development, is to establish and guide the next generation through one's acts of care. Five statuses, or prototypic styles of resolving the issues of this stage, determined using a new, semistructured interview measure, are defined using combinations of (1) an individual's level of involvement, or active concern for the growth of the self and others; and (2) an individual's inclusivity, or scope of caregiving concern. Construct validation efforts sought concurrent validity using two different scale measures of generativity, and discrimination between status profiles using the NEO Personality Inventory and Loevinger's Sentence Completion Test of ego development. Results generally support the new status model and point to areas of conceptual convergence and divergence between this approach and other generativity measures. 相似文献