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111.
Testosterone (T) may enhance cognitive performance. However, its mechanisms are not well understood. First, we hypothesized that if T's effects are mediated in part through actions of its 5alpha-reduced metabolites, dihydrotestosterone (DHT) and/or 3alpha-androstanediol (3alpha-diol) in the hippocampus, then T, DHT, and 3alpha-diol-administration directly to the hippocampus should enhance learning and memory in the inhibitory avoidance task. In order to test this hypothesis, gonadectomized (GDX) male rats were administered T, DHT, or 3alpha-diol via intrahippocampal inserts immediately following training in the inhibitory avoidance task. We found that T tended to increase, and DHT and 3alpha-diol significantly increased, performance in the inhibitory avoidance task compared to vehicle-administered GDX rats. Second, we hypothesized that, if androgens' effects are due in part to actions of 3alpha-diol in the hippocampus, then systemic or intrahippocampal administration of 3alpha-diol should significantly enhance cognitive performance of GDX male rats. Third, we hypothesized that, if androgen metabolites can have actions at estrogen receptors (ERs) in the hippocampus, then administration of ER antisense oligonucleotides (AS-ODNs) directly to the hippocampus of GDX, 3alpha-diol replaced, rats would decrease learning in the inhibitory avoidance task. We found that intrahippocampal administration of AS-ODNs for ERbeta, but not ERalpha, significantly decreased learning and memory of 3alpha-diol replaced rats. Together, these findings suggest that T's effects to enhance learning and memory may take place, in part, through actions of its metabolite, 3alpha-diol, at ERbeta in the dorsal hippocampus. 相似文献
112.
People so readily generalize that they often 'know' in advance what they are going to like and what they are going to dislike. They develop assumptions and expectations, which in part determine their future evaluative responses. Biased assimilation occurs when perceptions of new evidence are interpreted in such a way as to be assimilated into preexisting assumptions and expectations. Because this bias may not be deliberate, people suspect the motives of others who do not share their evaluations, and the bias is difficult to overcome. Biased assimilation most likely occurs, however, because acting as though one's assumptions and expectations are correct is generally more adaptive than acting as though one's assumptions and expectations might be wrong. Therefore, overcoming a general tendency toward biased assimilation is not necessarily desirable. 相似文献
113.
114.
Justin M. Carré Cheryl M. McCormick Catherine J. Mondloch 《Psychological science》2009,20(10):1194-1198
ABSTRACT— Facial width-to-height ratio is a sexually dimorphic metric that is independent of body size and may have been shaped by sexual selection. We recently showed that this metric is correlated with behavioral aggression in men. In Study 1, observers estimated the propensity for aggression of men photographed displaying neutral facial expressions and for whom a behavioral measure of aggression was obtained. The estimates were correlated strongly with the facial width-to-height ratio of the stimulus faces and with the actual aggression of the men. These results were replicated in Study 2, in which the exposure to each stimulus face was shortened to 39 ms. Participants' estimates of aggression for each stimulus face were highly correlated between Study 2 (39-ms exposure) and Study 1 (2,000-ms exposure). These findings suggest that the facial width-to-height ratio may be a cue used to predict propensity for aggression in others. 相似文献
115.
Yolanda Ridge Karen Panabaker Mary McCullum Cheryl Portigal-Todd Jenna Scott Barbara McGillivray 《Journal of genetic counseling》2009,18(1):87-100
As demand for genetic counseling regarding hereditary cancer continues to grow, more efficient methods of providing this service
must be explored. In this pilot study, group genetic counseling was offered to two different cohorts of women seeking genetic
counseling for Hereditary Breast and Ovarian Cancer. Seven group sessions, designed to cover all aspects of an individual
genetic counseling appointment, were conducted. Although patients were receptive to group genetic counseling, a significant
proportion chose individual counseling when given the option. Advantages of group genetic counseling include shared experience
and increased efficiency. Disadvantages include increased frustration at not being eligible for genetic testing, group influence
on decision-making, privacy concerns, increased need for follow-up, and difficulty booking group appointments. Overall, the
level of patient satisfaction with group genetic counseling was similar to that of individual counseling. The results of this
pilot study suggest that further research is needed to determine whether group genetic counseling is an acceptable alternative
to individual counseling. 相似文献
116.
Dwayne Devonish Philmore A. Alleyne Cheryl Cadogan-McClean Dion Greenidge 《Journal of Academic Ethics》2009,7(3):159-173
This paper sought to test whether student demographics (gender, age, religion, type of degree and number of courses done containing ethics) influenced the likelihood of engaging in unethical business practices. The study involved the use of a questionnaire being administered to a sample of 231 undergraduate students in Barbados. It was found that gender, religiousness, type of degree and number of courses taken containing ethics significantly impacted on the intentions to engage in unethical behaviour. It was also found that the impact of age was not conclusive. The study has several limitations including low generalisability due to the use of a non-probability sampling method, and the possibility of social desirability bias. The study informs educators about the need to integrate ethics into the curriculum as an essential component of professional training for future managers and business people. This study makes an important contribution to the ethics literature on small island developing states, since the study was done in the country of Barbados. 相似文献
117.
Cline CA 《The American journal of bioethics : AJOB》2007,7(10):15-7; discussion 1-3
118.
Kerr DC Washburn JJ Feingold A Kramer AC Ivey AZ King CA 《Journal of abnormal child psychology》2007,35(5):817-830
The consequences of aggression on problem course and suicide risk were examined in 270 acutely suicidal adolescents (ages 12-17 years; 184 girls). Participants were assessed during psychiatric hospitalization (T1), 6-months post-hospitalization (T2), and 15 or more months post-hospitalization (T3). Study variables included self- and parent-reported aggression; self-reported internalizing symptoms, suicidal ideation, suicide attempt, and adverse events; and clinician-rated suicidal behavior. Aggression was not directly related to suicide attempt concurrently or prospectively. However, among more aggressive youth, internalizing symptoms were more predictive of T3 suicide attempt than among less aggressive youth. T1 aggression predicted aggressive incidents and the likelihood of incarceration prior to T3. Two-level hierarchical linear modeling indicated that self-reported aggression and internalizing problems were linked in terms of severity and rates of decline over time. Overall, parent-reported aggression was negatively associated with suicidal ideation. Findings highlight (a) the continuity and consequences of aggression, (b) a possible role of aggression in worsening suicide risk factors and potentiating suicide attempt, and (c) the importance of ongoing research on subtypes of suicidal adolescents. 相似文献
119.
Genetic studies of stuttering in a founder population 总被引:2,自引:0,他引:2
Wittke-Thompson JK Ambrose N Yairi E Roe C Cook EH Ober C Cox NJ 《Journal of Fluency Disorders》2007,32(1):33-50
Genome-wide linkage and association analyses were conducted to identify genetic determinants of stuttering in a founder population in which 48 individuals affected with stuttering are connected in a single 232-person genealogy. A novel approach was devised to account for all necessary relationships to enable multipoint linkage analysis. Regions with nominal evidence for linkage were found on chromosomes 3 (P=0.013, 208.8 centiMorgans (cM)), 13 (P=0.012, 52.6 cM), and 15 (P=0.02, 100 cM). Regions with nominal evidence for association with stuttering that overlapped with a linkage signal are located on chromosomes 3 (P=0.0047, 195 cM), 9 (P=0.0067, 46.5 cM), and 13 (P=0.0055, 52.6 cM). We also conducted the first meta-analysis for stuttering using results from linkage studies in the Hutterites and The Illinois International Genetics of Stuttering Project and identified regions with nominal evidence for linkage on chromosomes 2 (P=0.013, 180-195 cM) and 5 (P=0.0051, 105-120 cM; P=0.015, 120-135 cM). None of the linkage signals detected in the Hutterite sample alone, or in the meta-analysis, meet genome-wide criteria for significance, although some of the stronger signals overlap linkage mapping signals previously reported for other speech and language disorders. EDUCATIONAL OBJECTIVES: After reading this article, the reader will be able to: (1) summarize information about the background of common disorders and methodology of genetic studies; (2) evaluate the role of genetics in stuttering; (3) discuss the value of using founder populations in genetic studies; (4) articulate the importance of combining several studies in a meta-analysis; (5) discuss the overlap of genetic signals identified in stuttering with other speech and language disorders. 相似文献
120.
Positive and Negative Expectations of Hopelessness as Longitudinal Predictors of Depression,Suicidal Ideation,and Suicidal Behavior in High‐Risk Adolescents
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Adam G. Horwitz MS Johnny Berona MS Ewa K. Czyz PhD Carlos E. Yeguez BS Cheryl A. King PhD 《Suicide & life-threatening behavior》2017,47(2):168-176
The relationship between hopelessness and depression in predicting suicide‐related outcomes varies based on the anticipation of positive versus negative events. In this prospective study of adolescents at elevated risk for suicide, we used two Beck Hopelessness Scale subscales to assess the impact of positive and negative expectations in predicting depression, suicidal ideation, and suicidal behavior over a 2‐ to 4‐year period. In multivariate regressions controlling for depression, suicidal ideation, and negative‐expectation hopelessness, positive‐expectation hopelessness was the only significant predictor of depressive symptoms and suicidal behavior. Clinical interventions may benefit from bolstering positive expectations and building optimism. 相似文献