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Epigenetic testing is one of the most significant new technologies to provide insight into the behavioral and environmental factors that influence the development and reconfiguration of the human genetic code. This technology allows us to identify structural changes in the genome that occur due to exposure to a wide variety of substances including alcohol, tobacco, and cannabis. The information gained can be used to promote health but it also raises a variety of ethical, legal, and social issues. As society progresses in understanding the epigenetic mechanisms of substance use and addiction, there is an opportunity to use these use this knowledge to enable medical, behavioral, and environmental interventions to alleviate the burden of addiction. This article describes the ethical issues associated with use of epigenetic testing for alcohol, tobacco, and cannabis and the implications of this technology. A further review of the scientific basis for the relevance of epigenetics is found in the accompanying article by Philibert and Erwin in this issue. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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Jeffrey A. Kleim Michelle A. Pipitone Cheryl Czerlanis William T. Greenough 《Neurobiology of learning and memory》1998,69(3):290-306
Complex motor learning, but not mere motor activity, has been previously shown to induce structural modifications within the cerebellar cortex. The present experiment examined whether similar changes occur within one of the primary output targets of the region of the cerebellar cortex in which these structural changes were described, the lateral cerebellar nucleus (LCN; dentate nucleus). Adult female rats were randomly allocated to one of three training conditions. Acrobatic condition (AC) rats were trained to complete a complex motor learning task consisting of a series of elevated obstacles while motor control (MC) condition animals were forced to traverse a flat obstacle-free runway equal in length to the AC task. Inactive condition (IC) animals received no motor training. Unbiased stereological techniques and electron microscopy were used to obtain estimates of synapse number and postsynaptic density (PSD) length within the LCN. Results showed that neither synapse number nor PSD length was significantly altered as a function of training condition. These results indicate that complex motor skill learning is associated with structural plasticity within the cerebellar cortex and with structural stability within the lateral cerebellar nucleus. 相似文献
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Cheryl A. Burgess Irving Kirsch Howard Shane Kristen L. Niederauer Steven M. Graham & Alyson Bacon 《Psychological science》1998,9(1):71-74
Forty college students were taught facilitated communication via a commercially available training videotape. They were then asked to facilitate the communication of a confederate, who was described as developmentally disabled and unable to speak. All 40 participants produced responses that they attributed at least partially to the confederate, and most attributed all of the communication entirely to her. Eighty-nine percent produced responses corresponding to information they had received, most of which was unknown to the confederate. Responding was significantly correlated with simple ideomotor responses with a pendulum and was not affected by information about the controversy surrounding facilitated communication. These data support the hypothesis that facilitated communication is an instance of automatic writing, akin to that observed in hypothesis and with Ouija boards, and that the ability to produce automatic writing is more common than previously thought. 相似文献
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Theology of the Cross and the Experience of God's Presence: A Lutheran Response to Pentecostal Wonderings 下载免费PDF全文
Cheryl M. Peterson 《Dialog》2016,55(4):316-323
As Lutherans and Pentecostals begin an official international dialogue, the author, a Lutheran member of the dialogue, responds to two related sets of questions raised by a Pentecostal member of the dialogue during a preceding six‐year consultation between these traditions: whether there is a place in the Lutheran tradition for a “theology of glory,” considering the centrality of “a theology of the cross” for Luther; and how Lutherans speak about experiencing the presence of God, and the means through which one encounters God. 相似文献
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Cheryl L. Somers Angelique G. Day Monica M. Chambers Katie A. Wendler Hillary A. Culp Beverly A. Baroni 《Current psychology (New Brunswick, N.J.)》2016,35(1):131-141
The purpose of this research was to better understand the substance use and sexual risk taking behavior among high-risk adolescent populations placed in residential treatment facilities, including those in the foster care and juvenile justice systems. The primary predictors considered in this study included caregiver support, caregiver closeness, other adult support, adolescent self-disclosure/communication with caregiver, caregiver expectations about sexual behavior, and peer influence regards to drugs/alcohol and sexual behavior. Participants included 120 adolescent females in grades 7 to 12 (median grade?=?10; mean age 15.7 years), primarily African American (57.2 %) and White (29 %), in a residential treatment setting in a large urban area in the Midwest. Caregiver support and self-disclosure/communication with caregivers predicted condom use at most recent intercourse, but variables related to substance use were most consistently predictive of sexuality variables including onset and frequency of behavior. None of these support variables significantly predicted onset and frequency of substance use. Caregiver support was the contributing variable in predicting academic achievement. 相似文献
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The author examined the underlying factors of the Association of Multicultural Counseling and Development's (AMCD) Multicultural Competencies. One hundred fifty‐one professional counselors who are members of the American Counseling Association responded to a survey that included items reflecting AMCD's multicultural competencies and Explanatory Statements. An exploratory factor analysis revealed 5 multicultural competencies factors: Awareness, Knowledge, Definitions of Terms, Racial Identity Development, and Skills. 相似文献