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Epigenetic testing is one of the most significant new technologies to provide insight into the behavioral and environmental factors that influence the development and reconfiguration of the human genetic code. This technology allows us to identify structural changes in the genome that occur due to exposure to a wide variety of substances including alcohol, tobacco, and cannabis. The information gained can be used to promote health but it also raises a variety of ethical, legal, and social issues. As society progresses in understanding the epigenetic mechanisms of substance use and addiction, there is an opportunity to use these use this knowledge to enable medical, behavioral, and environmental interventions to alleviate the burden of addiction. This article describes the ethical issues associated with use of epigenetic testing for alcohol, tobacco, and cannabis and the implications of this technology. A further review of the scientific basis for the relevance of epigenetics is found in the accompanying article by Philibert and Erwin in this issue. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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The staggering rate at which incidents of child pornography (CP) are increasing highlights the need for proactive approaches to this problem. Improving the efficacy and accessibility of interventions designed for individuals who view CP provides one means of addressing this growing concern. This article explores the self-identified motivations underlying the onset and maintenance of viewing Internet-based CP among a sample of 20 men receiving treatment for this behavior. Our findings suggest two primary motivational pathways, namely a desire to achieve sexual gratification and/or an attempt to avoid emotional pain. We propose a behavioral facilitation process, initiated by extensive exposure to Internet pornography, to explain the use of CP in men without a sexual interest in children. We also discuss factors that appeared to facilitate the maintenance of this behavior. Our findings indicate that social skills deficits, maladaptive coping strategies, and a lack of sexual education require further investigation regarding their role in promoting or precluding desistance from viewing CP. 相似文献
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Jeffrey A. Kleim Michelle A. Pipitone Cheryl Czerlanis William T. Greenough 《Neurobiology of learning and memory》1998,69(3):290-306
Complex motor learning, but not mere motor activity, has been previously shown to induce structural modifications within the cerebellar cortex. The present experiment examined whether similar changes occur within one of the primary output targets of the region of the cerebellar cortex in which these structural changes were described, the lateral cerebellar nucleus (LCN; dentate nucleus). Adult female rats were randomly allocated to one of three training conditions. Acrobatic condition (AC) rats were trained to complete a complex motor learning task consisting of a series of elevated obstacles while motor control (MC) condition animals were forced to traverse a flat obstacle-free runway equal in length to the AC task. Inactive condition (IC) animals received no motor training. Unbiased stereological techniques and electron microscopy were used to obtain estimates of synapse number and postsynaptic density (PSD) length within the LCN. Results showed that neither synapse number nor PSD length was significantly altered as a function of training condition. These results indicate that complex motor skill learning is associated with structural plasticity within the cerebellar cortex and with structural stability within the lateral cerebellar nucleus. 相似文献
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Cheryl A. Burgess Irving Kirsch Howard Shane Kristen L. Niederauer Steven M. Graham & Alyson Bacon 《Psychological science》1998,9(1):71-74
Forty college students were taught facilitated communication via a commercially available training videotape. They were then asked to facilitate the communication of a confederate, who was described as developmentally disabled and unable to speak. All 40 participants produced responses that they attributed at least partially to the confederate, and most attributed all of the communication entirely to her. Eighty-nine percent produced responses corresponding to information they had received, most of which was unknown to the confederate. Responding was significantly correlated with simple ideomotor responses with a pendulum and was not affected by information about the controversy surrounding facilitated communication. These data support the hypothesis that facilitated communication is an instance of automatic writing, akin to that observed in hypothesis and with Ouija boards, and that the ability to produce automatic writing is more common than previously thought. 相似文献
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