Measuring and predicting the effects of alcohol consumption on contrast sensitivity for stationary and moving gratings

Contrast sensitivity was measured for 12 healthy young males while sober, after ingestion of an alcohol placebo, and after ingestion of alcohol (95% grain alcohol; mean estimated blood alcohol level = .088%). Observations were made for both stationary gratings and gratings that traveled through a circular path and required pursuit eye movements. The significant alcohol-related reduction in contrast sensitivity was 2.6 times greater for moving (.29-log-unit reduction) than for stationary gratings (.11-log-unit reduction). The loss in contrast sensitivity for the moving gratings of high spatial frequency (12 cpd) was particularly severe (.37 log unit). Estimated blood alcohol level was correlated with the loss in contrast sensitivity for moving gratings (r = .61), but not with the loss for stationary gratings. Estimated blood alcohol level was strongly correlated with the difference between the loss in contrast sensitivity to moving and stationary gratings (r = .75). These results are consistent with reports that alcohol consumption degrades the ability to make pursuit eye movements. Subjects’ perceived intoxication level was not a reliable predictor of any index of visual performance.     

创业倾向影响因素研究

本文是有关个体创业倾向与其社会环境、个性特征以及其它相关因素的研究。目的是为了探讨个体的个性特征以及环境、背景等因素对其创业倾向的影响。研究以国际前沿的理论为基础，以建立个体创业倾向的影响因素模型为目标。来研究个体创业倾向与社会环境、个性特征等影响因素的关系。     

人格结构的动态分析

为了动态化地分析人格的结构。研究一采用个体性自由命名描述法考察人格的动态内容。１５０名大学生分别用１０个词描述实际的自我、理想的自我、应该的自我。词频统计反映了不同自我的内容特点。研究二采用常模化限定性描述法考察人格的结构特点,用研究珠高频词制成实际、理想、应该的自我词表。２００名大学生用７点量表分别评定各词表中的每个词适合描述相应的自我的程度。结果表明,实际的自我有５个因素,解释４７．１％的变异     

7－15岁儿童对友谊关系的认知及其发展

用以承诺为主题的两难推理故事探查７－１５岁儿童对友谊关系的认知及其发展。结果表明,儿童的有关发展制约于社会观点采择能力的发展和调节友谊关系的道德规范的理解,并表现出阶段结构的发展模式,我国儿童的发展具有某种跨文化的普遍性,也显示出自己的特点。     

结果预期与结果反应对儿童意图认知和道德判断的影响

考察了结果预期与结果反应对儿童意图认知和道德判断的影响。结果表明,结果预期影响幼儿园和小学儿童的意图认知,结果反应仅影响幼儿园儿童的意图认知;结果预期和结果反应显著地影响幼儿园和小学儿童的道德判断,但结果预期对小学儿童道德判断的影响要比结果反应大。     

侧脑室注射东莨菪碱对条件反射及对海马神经元自发放电的影响

本工作采用食物性运动,条件反射方法和慢性微电极记录技术。条件反射实验在9只兔上进行,海马自发放电的实验在22只兔上进行。在9次实验中,30μg的东莨菪碱注入一侧脑室后,条件反射均受到抑制,而吃食则不受影响。注射剂量为45μg时,注射后3—5分,条件反射完全消失,而吃食行为在了次实验中不受影响,在2次实验中稍有减弱,注射后20分钟左右条件反射开始恢复;侧脑室注射40μg的东莨菪碱后,海马神经元的自发活动无明显改变。文中并对抗胆碱药作用于海马抑制条件反射的可能方式进行了讨论。     

20岁至90岁成人的某些记忆活动的变化

本工作是我们过去关于记忆年老化研究的继续。记忆材料为自行设计并与全国若干单位协作编制的“试用临床记忆量表”。受试为健康成人210名.分为7个年龄组,各组性别、文化匹配。每组有20名并作韦氏成人智力量表检查。结果:1.成年至老年记忆变化总的趋势是,50岁组开始有明显减退,70岁后又有更显著的减退。2.在智力匹配条件下记忆年老化趋势相同(20、40、50、60、70岁年龄组)。3.无意义图形再认和有关联想学习年龄差异最小,无关联想学习和人像的姓氏,爱好特点回忆年龄差异最大,表明老年人建立无关的全新的联系困难。据此,作者指出老年记忆障碍可能是编码储存和提取困难相互作用的结果。     

Pharmacological dissociation of memory: anisomycin, a protein synthesis inhibitor, and leupeptin, a protease inhibitor, block different learning tasks

Inhibition of protein synthesis by anisomycin for a short duration impairs memory of a one-trial inhibitory avoidance task in rats. Memory of escape conditioning involving eight trials is disrupted only if the duration of protein synthesis is prolonged by repeated injections. In marked contrast, olfactory memory of rats trained on two odor discriminations is not affected by anisomycin even if the duration of inhibition is prolonged and the number of trials is reduced to a minimum. In previous work, leupeptin, a thiol proteinase inhibitor, was shown to impair olfactory discrimination learning, but left inhibitory and avoidance conditioning intact. Together, these results provide a pharmacological double dissociation of memory, and suggest that the same chemistries, or mixtures of chemistries, may not be involved in all types of memory.     

Exploration and avoidance in rats with lesions in amygdala and piriform cortex

Lesions localized to specific areas of the amygdala and overlying cortex in rats produced differential effects in several behavioral tasks. Three different types of lesions were tested: central, basolateral, and cortex lateral to the amygdala. Lesions restricted to the central nucleus produced increased activity on all parameters studied in an open-field test, but the other two groups were not changed. In one-way active avoidance all three groups with lesions showed deficits. The most pronounced change was observed in the central group. All groups showed the same degree of retention loss, but in forced extinction of one-way active avoidance after retraining, the cortical and basolateral groups were most defective. A fear-reduction hypothesis is proposed for the central lesion. The basolateral and cortical areas may be more specifically involved in passive avoidance behavior.     

Differential indications for desipramine--results of a controlled multiclinical study]

The antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective symptoms, which was not detectable for the inhibition of drive. The tachythymoleptic action of desipramine is discussed with reference to these results. Evaluation of the possibility of controlling affects shows different ranges of activity of desipramine and imipramine, with desipramine influencing especially negative psychoenergetic symptoms in the area of drives and emotions and imipramine, restrictive symptoms in addition to differential phenomena of the psychomotor expression.