On the participation of mTOR in recognition memory

Evidence indicates that activation of the neuronal protein synthesis machinery is required in areas of the brain relevant to memory for consolidation and persistence of the mnemonic trace. Here, we report that inhibition of hippocampal mTOR, a protein kinase involved in the initiation of mRNA translation, immediately or 180min but not 540min after training impairs consolidation of long-term object recognition memory without affecting short-term memory retention or exploratory behavior. When infused into dorsal CA1 after long-term memory reactivation in the presence of familiar objects the mTOR inhibitor rapamycin (RAP) did not affect retention. However, when given immediately after exposing animals to a novel and a familiar object, RAP impaired memory for both of them. The amnesic effect of the post-retrieval administration of RAP was long-lasting, did not happen after exposure to two novel objects or following exploration of the training arena in the absence of other stimuli, suggesting that it was contingent with reactivation of the consolidated trace in the presence of a behaviorally relevant and novel cue. Our results indicate that mTOR activity is required in the dorsal hippocampus for consolidation of object recognition memory and suggest that inhibition of this kinase after memory retrieval in the presence of a particular set of cues hinders persistence of the original recognition memory trace.     

Using a model to compute the optimal schedule of practice

By balancing the spacing effect against the effects of recency and frequency, this paper explains how practice may be scheduled to maximize learning and retention. In an experiment, an optimized condition using an algorithm determined with this method was compared with other conditions. The optimized condition showed significant benefits with large effect sizes for both improved recall and recall latency. The optimization method achieved these benefits by using a modeling approach to develop a quantitative algorithm, which dynamically maximizes learning by determining for each item when the balance between increasing temporal spacing (that causes better long-term recall) and decreasing temporal spacing (that reduces the failure related time cost of each practice) means that the item is at the spacing interval where long-term gain per unit of practice time is maximal. As practice repetitions accumulate for each item, items become stable in memory and this optimal interval increases.     

A Pilot Study of Culturally Adapted Cognitive Behavior Therapy for Hispanics with Major Depression

The purpose of this study was to evaluate a culturally adapted cognitive-behavioral treatment (CBT) for major depression among Hispanics in primary care. Cultural adaptations were applied based on a range of cultural considerations described in the literature. Fifteen Hispanic primary care patients with major depression were enrolled. All participants received the 12-session intervention and completed baseline, posttreatment, and 6-month follow-up assessments. Four participants (27%) dropped out of the treatment. Analyses focused on changes from baseline functioning using a Wilcoxon Signed Rank Test. Results showed significant reductions in depressive, anxious, and somatic symptoms at posttreatment and 6-month follow-up. Mean reduction of depressive symptoms at posttreatment was 57%. Findings of acceptable treatment retention rates and clinically meaningful reductions in depressive symptoms showed promise for this intervention to treat Hispanics with major depression. Future studies should conduct a more rigorously controlled evaluation of this intervention.     

An examination of message-relevant affect in road safety messages: Should road safety advertisements aim to make us feel good or bad?

Drawing upon the multiple roles of affect posited by Elaboration Likelihood Model, the current paper examines the effectiveness of message-relevant affect. Specifically, humourous and fear-evoking anti-drink driving messages are examined in terms of perceptions of relative influence on self and others (i.e., the third-person effect) and their performance on a range of persuasion outcomes. The influence of involvement, response efficacy, and gender on persuasion outcomes is also examined. Participants (N = 201) viewed two advertisements and completed two questionnaires: the first, assessed pre-exposure attitudes and behaviour and immediate-post exposure attitudes and intentions; the second, 2–4 weeks later, assessed attitudes and behaviour. The results revealed, as predicted, interactions of the key variables and evidence of the greater persuasiveness of negative appeals immediately after exposure whilst greater improvement of positive appeals over time. The findings highlight the importance of continuing the exploration of positive appeals as a persuasive alternative to negative appeals.     

The rank hypothesis and lexical decision: a reply to Adelman and Brown (2008)

J. S. Adelman and G. D. A. Brown (2008) provided an extensive analysis of the form of word frequency and contextual diversity effects on lexical decision time. In this reply, the current authors suggest that their analysis provides a valuable tool for the evaluation of models of lexical access and that the results they report are broadly supportive of the rank hypothesis suggested by W. S. Murray and K. I. Forster (2004)--more supportive, in fact, than the originally reported data. However, Adelman and Brown's conclusion that the results of these analyses can be taken as evidence against rank (and thereby serial models of lexical access) and for instance models is rejected. It is shown that at least one instance model makes the wrong predictions and that Adelman and Brown's conclusions rest on the assumption that lexical decision time presents a pure measure of the time involved in lexical access. Results from eye tracking are reported, which also support a rank account, as do results from analyses that show that a log frequency account is clearly inadequate. Finally, it is demonstrated that, unlike other models, the rank account continues to make accurate predictions regarding the form of both reaction time and error rate effects.     

Emotional expression modulates perceived gaze direction

Gaze perception is an important social skill, as it portrays information about what another person is attending to. Gaze direction has been shown to affect interpretation of emotional expression. Here the authors investigate whether the emotional facial expression has a reciprocal influence on interpretation of gaze direction. In a forced-choice yes-no task, participants were asked to judge whether three faces expressing different emotions (anger, fear, happiness, and neutral) in different viewing angles were looking at them or not. Happy faces were more likely to be judged as looking at the observer than were angry, fearful, or neutral faces. Angry faces were more often judged as looking at the observer than were fearful and neutral expressions. These findings are discussed on the background of approach and avoidance orientation of emotions and of the self-referential positivity bias.     

Creating physically accurate visual stimuli for free: Spectral rendering with RADIANCE

Visual psychophysicists, who study object, color, and light perception, have a demand for software that produces complex but, at the same time, physically accurate stimuli for their experiments. The number of computer graphic packages that simulate the physical interaction of light and surfaces is limited, and mostly they require the purchase of a license. RADIANCE (Ward, 1994), however, is freely available and popular in the visual perception community, making it a prime candidate. We have shown previously that RADIANCE's simulation accuracy is greatly improved when color is coded by spectra, rather than by the originally envisaged RGB triplets (Ruppertsberg & Bloj, 2006). Here, we present a method for spectral rendering with RADIANCE to generate hyperspectral images that can be converted to XYZ images (CIE 1931 system) and then to machine-dependent RGB images. Generating XYZ stimuli has the added advantage of making stimulus images independent of display devices and, thereby, facilitating the process of reproducing results across different labs. Materials associated with this article may be downloaded from www.psychonomic.org.     

Organizational socialization tactics and newcomer proactive behaviors: An integrative study

The purpose of this study was to examine the relationship between organizational socialization tactics, newcomers’ self-efficacy, proactive behaviors, and socialization outcomes. Based on a sample of 140 co-op university students who completed surveys at the end of their work term, the results indicated that newcomers’ self-efficacy and institutionalized socialization tactics were positively related to newcomer proactive behaviors. The results also indicated that newcomer proactive behaviors partially mediated the relationship between their self-efficacy and organizational socialization tactics with a number of proximal and distal socialization outcomes. Furthermore, feedback-seeking and information-seeking moderated the relationship between socialization tactics and several socialization outcomes. Institutionalized socialization tactics were more strongly related to socialization outcomes for newcomers who engaged in less feedback-seeking and information-seeking behavior. These results support an interactionist approach to organizational socialization in which newcomers’ self-efficacy, proactive behavior, and organizational socialization tactics all contribute to newcomers’ adjustment and socialization.     

Pilot study for assessing the behaviors of patients with schizophrenia towards a virtual avatar.

This study examined whether a virtual avatar could be perceived as a real human by patients with mental disease, especially schizophrenia, as well as whether a virtual avatar could be applied to acquiring patients' behavior characteristics in a short conversation situation. The virtual avatar has been used for various applications which need to communicate with other person or to train or educate by showing humanlike behavior. Recently, many researches have shown that the virtual avatar technology has been enhanced and the avatar could be perceived like real human. A virtual avatar, standing in a virtual room, was designed for this study. Tasks to approach, initiate a talk, and answer to avatar's questions was assigned to the 11 patients with schizophrenia. As behavioral parameters in the virtual environment, the interpersonal distance and the verbal response time were acquired. In addition, the Positive and Negative Syndrome Scale (PANSS) for patients was administered in order to investigate the relationship between patients' symptomatic characteristics and behavior parameters. The interpersonal distance was negatively correlated with the negative syndrome scale, a subscale of PANSS, which is consistent with previous research reporting the relationship between interpersonal distance and a real person's image. The verbal response time, however, was not correlated with any other subscale of PANSS. After analyzing subitems of the negative syndrome of PANSS, two positive correlations were found: one was with blunted affect and the other was with poor rapport. We concluded that the virtual avatar could be perceived as a real human by schizophrenic patients and the avatar could draw the schizophrenic patients' behavior characteristics.     

Gender, Internet use, and sexual behavior orientation among young Nigerians.

This study examined the influence of gender and Internet use on the sexual behavior orientation of young adults in Nigeria. Using an ex-post-facto design, data were collected from a total of 231 participants. Results of the hierarchical regression model provided support for the influence of gender and Internet use on sexual behavior orientation among young Nigerians. Further, results also revealed an interaction effect; as the use of the Internet increased, male participants reported a greater extent of risky sexual behavior orientation than their female counterparts. The findings were explained in the context of the theoretical foundations of the study, while practical implications for combating youths' risky sexual behavior orientation were highlighted.