Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder

Classical fear-conditioning is central to many etiologic accounts of panic disorder (PD), but few lab-based conditioning studies in PD have been conducted. One conditioning perspective proposes associative-learning deficits characterized by deficient safety learning among PD patients. The current study of PD assesses acquisition and retention of discriminative aversive conditioning using a fear-potentiated startle paradigm. This paradigm was chosen for its specific capacity to independently assess safety- and danger learning in the service of characterizing putative anomalies in each type of learning among those with PD. Though no group difference in fear-potentiated startle was found at retention, acquisition results demonstrate impaired discriminative learning among PD patients as indexed by measures of conditioned startle-potentiation to learned safety and danger cues. Importantly, this discrimination deficit was driven by enhanced startle-potentiation to the learned safety cue rather than aberrant reactivity to the danger cue. Consistent with this finding, PD patients relative to healthy individuals reported higher expectancies of dangerous outcomes in the presence of the safety cue, but equal danger expectancies during exposure to the danger cue. Such results link PD to impaired discrimination learning, reflecting elevated fear responding to learned safety cues.     

Perceived organizational support, organizational commitment and psychological well-being: A longitudinal study

Using longitudinal data (N = 220), we examined the contribution of perceived organizational support and four mindsets of organizational commitment (affective, normative, perceived sacrifice associated with leaving and perceived lack of alternatives) to employee psychological well-being. In order to assess the contribution of support and commitment independently from workplace stressors, we controlled for the effects of role ambiguity, role conflict and role overload. Analyses showed affective organizational commitment to mediate a positive relationship between perceived organizational support and well-being. In addition, perceived organizational support negatively related to perceived lack of employment alternatives which, in turn, was negatively related to well-being. Normative commitment and perceived sacrifice associated with leaving were unrelated to well-being. The implications of these findings are discussed under the lenses of social exchange and conservation of resources theories.     

Nonstandard career paths and profiles of commitment to life roles: A complex relation

The career paths (ascending, interesting, uninteresting, descending) of 124 White Canadian francophones (62 men, 62 women) who had experienced nonstandard and precarious work for the last three years were examined in relation to the participants’ profiles of commitment to three life roles (work, family, and duality, that is, investment in both career and family). The paths were derived from the content analysis of the data collected through semi-structured individual interviews. Quantitative tools were used to assess the importance of life roles and to compare the career paths as well as the commitment profiles with respect to specific and general anxiety. Among other results, a significant relationship was found between unsatisfying career paths and the duality profile, on the one hand, and higher levels of specific and general anxiety, on the other. The results are discussed with respect to the scientific literature. Implications for career counseling are suggested.     

Nonlocal effects of prosodic boundaries

Placing a prosodic boundary before a phrase may influence its syntactic analysis. However, the boundary’s effect depends on the presence, size, and position of other, earlier, prosodic boundaries. In three experiments, we extend previous results about the effect of the position of the early boundary. In sentences in which a final phrase may modify either a local verb or an earlier verb, a boundary immediately after the first verb leads to more first-verb attachments than when the earlier boundary appears in another position between the two verbs (Experiments 1 and 2). This effect cannot be attributed to weaker effects of more distant boundaries (Experiment 2), but is likely due to the first verb being more prominent when a boundary immediately follows it, since similar effects are observed when the verb is accented (Experiment 3). The results support the informative boundary hypothesis and show that the impact of earlier, nonlocal boundaries is not fully uniform.     

Mutual influence of implicit and explicit attitudes

Research and theory distinguish two types of attitude: automatic evaluative reactions and deliberate evaluative judgments, referred to as implicit and explicit attitudes, respectively. Although these attitudes are distinct, they may influence each other. Four studies tested whether implicit and explicit attitudes are both influenced by propositional and associative learning. We also tested whether changes in one kind of attitude mediate changes in the other. Study 1 found that propositional learning about novel individuals directly influenced explicit attitudes and indirectly influenced implicit attitudes through changes in explicit attitudes. Studies 2 and 3 replicated this finding and extended it by simultaneously demonstrating that associative learning through Evaluative Conditioning directly influences implicit attitudes and indirectly influences explicit attitudes through changes in implicit attitudes. Study 4 replicated these effects for attitudes toward familiar, rather than novel, targets. These results suggest that implicit and explicit attitudes can share common antecedents and influence each other.     

Imaging intelligence with proton magnetic resonance spectroscopy

Proton magnetic resonance spectroscopy (¹H-MRS) is a technique for the assay of brain neurochemistry in vivo. N-acetylaspartate (NAA), the most prominent metabolite visible within the ¹H-MRS spectrum, is found primarily within neurons. The current study was designed to further elucidate NAA–cognition relationships, particularly whether such relationships are moderated by sex, or tissue type (gray or white matter). We administered standard measures of intelligence to 63 young, healthy subjects and obtained spectroscopic imaging data within a slab of tissue superior to the lateral ventricles. We found that lower NAA within right anterior gray matter predicted better performance VIQ (F = 6.83, p = .011, r² = .10), while higher NAA within the right posterior gray matter region predicted better PIQ (F = 8.175, p = .006, r² = .12). These findings add to the small but growing body of literature linking brain biochemistry to intelligence in normal healthy subjects using ¹H-MRSI.     

Two routes to face perception: evidence from psychophysics and computational modeling

The aim of this study was to separately analyze the role of featural and configural face representations. Stimuli containing only featural information were created by cutting the faces into their parts and scrambling them. Stimuli only containing configural information were created by blurring the faces. Employing an old-new recognition task, the aim of Experiments 1 and 2 was to investigate whether unfamiliar faces (Exp. 1) or familiar faces (Exp. 2) can be recognized if only featural or configural information is provided. Both scrambled and blurred faces could be recognized above chance level. A further aim of Experiments 1 and 2 was to investigate whether our method of creating configural and featural stimuli is valid. Pre-activation of one form of representation did not facilitate recognition of the other, neither for unfamiliar faces (Exp. 1) nor for familiar faces (Exp. 2). This indicates a high internal validity of our method for creating configural and featural face stimuli. Experiment 3 examined whether features placed in their correct categorical relational position but with distorted metrical distances facilitated recognition of unfamiliar faces. These faces were recognized no better than the scrambled faces in Experiment 1, providing further evidence that facial features are stored independently of configural information. From these results we conclude that both featural and configural information are important to recognize a face and argue for a dual-mode hypothesis of face processing. Using the psychophysical results as motivation, we propose a computational framework that implements featural and configural processing routes using an appearance-based representation based on local features and their spatial relations. In three computational experiments (Experiments 4–6) using the same sets of stimuli, we show how this framework is able to model the psychophysical data.     

Functional Consequences of HIV-Associated Neuropsychological Impairment

This review focuses on the “real world” implications of infection with HIV/AIDS from a neuropsychological perspective. Relevant literature is reviewed which examines the relationships between HIV-associated neuropsychological impairment and employment, driving, medication adherence, mood, fatigue, and interpersonal functioning. Specifically, the relative contributions of medical, cognitive, psychosocial, and psychiatric issues on whether someone with HIV/AIDS will be able to return to work, adhere to a complicated medication regimen, or safely drive a vehicle will be discussed. Methodological issues that arise in the context of measuring medication adherence or driving capacity are also explored. Finally, the impact of HIV/AIDS on mood state, fatigue, and interpersonal relationships are addressed, with particular emphasis on how these variables interact with cognition and independent functioning. The purpose of this review is to integrate neuropsychological findings with their real world correlates of functional behavior in the HIV/AIDS population.     

Searching in the dark: Cognitive relevance drives attention in real-world scenes

We investigated whether the deployment of attention in scenes is better explained by visual salience or by cognitive relevance. In two experiments, participants searched for target objects in scene photographs. The objects appeared in semantically appropriate locations but were not visually salient within their scenes. Search was fast and efficient, with participants much more likely to look to the targets than to the salient regions. This difference was apparent from the first fixation and held regardless of whether participants were familiar with the visual form of the search targets. In the majority of trials, salient regions were not fixated. The critical effects were observed for all 24 participants across the two experiments. We outline a cognitive relevance framework to account for the control of attention and fixation in scenes.